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O69635 (ACSA_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A synthetase
EC=6.2.1.1
Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme
Gene names
Name:acsA
Synonyms:acs
Ordered Locus Names:Rv3667, MT3768
ORF Names:MTV025.015
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length651 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentcell wall

Inferred from direct assay. Source: MTBBASE

plasma membrane

Inferred from direct assay. Source: MTBBASE

   Molecular functionAMP binding

Inferred from electronic annotation. Source: InterPro

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

acetate-CoA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 651651Acetyl-coenzyme A synthetase HAMAP MF_01123
PRO_0000208369

Sites

Active site5251 By similarity

Amino acid modifications

Modified residue6171N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
O69635 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 94290C0517A0445B

FASTA65171,476
        10         20         30         40         50         60 
MSESTPEVSS SYPPPAHFAE HANARAELYR EAEEDRLAFW AKQANRLSWT TPFTEVLDWS 

        70         80         90        100        110        120 
GAPFAKWFVG GELNVAYNCV DRHVEAGHGD RVAIHWEGEP VGDRRTLTYS DLLAEVSKAA 

       130        140        150        160        170        180 
NALTDLGLVA GDRVAIYLPL IPEAVIAMLA CARLGIMHSV VFGGFTAAAL QARIVDAQAK 

       190        200        210        220        230        240 
LLITADGQFR RGKPSPLKAA ADEALAAIPD CSVEHVLVVR RTGIEMAWSE GRDLWWHHVV 

       250        260        270        280        290        300 
GSASPAHTPE PFDSEHPLFL LYTSGTTGKP KGIMHTSGGY LTQCCYTMRT IFDVKPDSDV 

       310        320        330        340        350        360 
FWCTADIGWV TGHTYGVYGP LCNGVTEVLY EGTPDTPDRH RHFQIIEKYG VTIYYTAPTL 

       370        380        390        400        410        420 
IRMFMKWGRE IPDSHDLSSL RLLGSVGEPI NPEAWRWYRD VIGGGRTPLV DTWWQTETGS 

       430        440        450        460        470        480 
AMISPLPGIA AAKPGSAMTP LPGISAKIVD DHGDPLPPHT EGAQHVTGYL VLDQPWPSML 

       490        500        510        520        530        540 
RGIWGDPARY WHSYWSKFSD KGYYFAGDGA RIDPDGAIWV LGRIDDVMNV SGHRISTAEV 

       550        560        570        580        590        600 
ESALVAHSGV AEAAVVGVTD ETTTQAICAF VVLRANYAPH DRTAEELRTE VARVISPIAR 

       610        620        630        640        650 
PRDVHVVPEL PKTRSGKIMR RLLRDVAENR ELGDTSTLLD PTVFDAIRAA K

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842583 Genomic DNA. Translation: CAA17989.1.
AE000516 Genomic DNA. Translation: AAK48135.1.
PIRD70789.
RefSeqNP_218184.1. NC_000962.2.
NP_338321.1. NC_002755.2.

3D structure databases

ProteinModelPortalO69635.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000001628; EBMYCP00000001628; EBMYCG00000001628.
EBMYCT00000071474; EBMYCP00000069533; EBMYCG00000071469.
GeneID885479.
922721.
GenomeReviewsGene locus MT3768 in contig AE000516_GR.
Gene locus Rv3667 in contig AL123456_GR.
KEGGmtc:MT3768.
mtu:Rv3667.
PATRIC18130050. VBIMycTub22151_4118.
TIGRMT3768.

Organism-specific databases

TubercuListRv3667.

Phylogenomic databases

GeneTreeEBGT00050000015141.
HOGENOMHBG547964.
OMAHQRMVDT.
PhylomeDBO69635.
ProtClustDBPRK00174.

Family and domain databases

HAMAPMF_01123. Ac_CoA_synth.
[Tree]
InterProIPR011904. Ac_CoA_lig.
IPR024597. Acyl-CoA_synth_DUF3448.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
KOK01895.
PANTHERPTHR24095:SF42. PTHR24095:SF42. 1 hit.
PfamPF00501. AMP-binding. 1 hit.
PF11930. DUF3448. 1 hit.
[Graphical view]
TIGRFAMsTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACSA_MYCTU
AccessionPrimary (citable) accession number: O69635
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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