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O69600

- ALF_MYCLE

UniProt

O69600 - ALF_MYCLE

Protein

Fructose-bisphosphate aldolase

Gene

fba

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Cofactori

    Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei53 – 531Glyceraldehyde 3-phosphateBy similarity
    Active sitei95 – 951Proton donorBy similarity
    Metal bindingi96 – 961Zinc 1; catalyticBy similarity
    Metal bindingi131 – 1311Zinc 2By similarity
    Metal bindingi161 – 1611Zinc 2By similarity
    Metal bindingi212 – 2121Zinc 1; catalyticBy similarity
    Binding sitei213 – 2131Dihydroxyacetone phosphate; via amide nitrogenBy similarity
    Metal bindingi252 – 2521Zinc 1; catalyticBy similarity

    GO - Molecular functioni

    1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase (EC:4.1.2.13)
    Short name:
    FBP aldolase
    Short name:
    FBPA
    Alternative name(s):
    Fructose-1,6-bisphosphate aldolase
    Gene namesi
    Name:fba
    Ordered Locus Names:ML0286
    ORF Names:MLCB4.29c
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML0286.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 345345Fructose-bisphosphate aldolasePRO_0000178721Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272631.ML0286.

    Structurei

    3D structure databases

    ProteinModelPortaliO69600.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni253 – 2553Dihydroxyacetone phosphate bindingBy similarity
    Regioni274 – 2774Dihydroxyacetone phosphate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0191.
    HOGENOMiHOG000227794.
    KOiK01624.
    OMAiHNSLDFV.
    OrthoDBiEOG69GZPB.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR006411. Fruct_bisP_bact.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view]
    PfamiPF01116. F_bP_aldolase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsiTIGR00167. cbbA. 1 hit.
    TIGR01520. FruBisAldo_II_A. 1 hit.
    PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
    PS00806. ALDOLASE_CLASS_II_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O69600-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPIATPEIYA EMLRRAKENS YAFPAINCTS SETVNAAIKG FADAGSDGII    50
    QFSTGGAEFA SGLGVKDMVT GAVALAKFTH TIAAKYPINV ALHTDHCPKD 100
    KLDSYVRPLL AISARRVATG KDPLFGSHMW DGSAIPIDEN LAIAQDLLKD 150
    AAAAKIILEV EIGVVGGEED GVAGEINEKL YTTPKDFVKT IDALGAGEHG 200
    KYLLAATFGN VHGVYKPGNV KLRPDILAEG QKVAAAKLSQ SEGSKPFDFV 250
    FHGGSGSEKS EIEEALRYGV VKMNVDTDTQ YAFTRPVSGH MFTNYDGVLK 300
    VDGDVGNKKV YDPRSYLKKA EASMTERVLE ACNDLRCAGK SVAAS 345
    Length:345
    Mass (Da):36,741
    Last modified:August 1, 1998 - v1
    Checksum:i29FE8474C41D00C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL023514 Genomic DNA. Translation: CAA18950.1.
    AL583918 Genomic DNA. Translation: CAC29794.1.
    PIRiF86944.
    RefSeqiNP_301326.1. NC_002677.1.
    WP_010907650.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC29794; CAC29794; CAC29794.
    GeneIDi908824.
    KEGGimle:ML0286.
    PATRICi18051002. VBIMycLep78757_0450.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL023514 Genomic DNA. Translation: CAA18950.1 .
    AL583918 Genomic DNA. Translation: CAC29794.1 .
    PIRi F86944.
    RefSeqi NP_301326.1. NC_002677.1.
    WP_010907650.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali O69600.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML0286.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC29794 ; CAC29794 ; CAC29794 .
    GeneIDi 908824.
    KEGGi mle:ML0286.
    PATRICi 18051002. VBIMycLep78757_0450.

    Organism-specific databases

    Lepromai ML0286.

    Phylogenomic databases

    eggNOGi COG0191.
    HOGENOMi HOG000227794.
    KOi K01624.
    OMAi HNSLDFV.
    OrthoDBi EOG69GZPB.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR006411. Fruct_bisP_bact.
    IPR000771. Ketose_bisP_aldolase_II.
    [Graphical view ]
    Pfami PF01116. F_bP_aldolase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
    TIGRFAMsi TIGR00167. cbbA. 1 hit.
    TIGR01520. FruBisAldo_II_A. 1 hit.
    PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
    PS00806. ALDOLASE_CLASS_II_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiALF_MYCLE
    AccessioniPrimary (citable) accession number: O69600
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3