SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O69600

- ALF_MYCLE

UniProt

O69600 - ALF_MYCLE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Fructose-bisphosphate aldolase
Gene
fba, ML0286, MLCB4.29c
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis By similarity.

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531Glyceraldehyde 3-phosphate By similarity
Active sitei95 – 951Proton donor By similarity
Metal bindingi96 – 961Zinc 1; catalytic By similarity
Metal bindingi131 – 1311Zinc 2 By similarity
Metal bindingi161 – 1611Zinc 2 By similarity
Metal bindingi212 – 2121Zinc 1; catalytic By similarity
Binding sitei213 – 2131Dihydroxyacetone phosphate; via amide nitrogen By similarity
Metal bindingi252 – 2521Zinc 1; catalytic By similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Fructose-1,6-bisphosphate aldolase
Gene namesi
Name:fba
Ordered Locus Names:ML0286
ORF Names:MLCB4.29c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0286.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Fructose-bisphosphate aldolase
PRO_0000178721Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0286.

Structurei

3D structure databases

ProteinModelPortaliO69600.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni253 – 2553Dihydroxyacetone phosphate binding By similarity
Regioni274 – 2774Dihydroxyacetone phosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0191.
HOGENOMiHOG000227794.
KOiK01624.
OMAiHNSLDFV.
OrthoDBiEOG69GZPB.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006411. Fruct_bisP_bact.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsiTIGR00167. cbbA. 1 hit.
TIGR01520. FruBisAldo_II_A. 1 hit.
PROSITEiPS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O69600-1 [UniParc]FASTAAdd to Basket

« Hide

MPIATPEIYA EMLRRAKENS YAFPAINCTS SETVNAAIKG FADAGSDGII    50
QFSTGGAEFA SGLGVKDMVT GAVALAKFTH TIAAKYPINV ALHTDHCPKD 100
KLDSYVRPLL AISARRVATG KDPLFGSHMW DGSAIPIDEN LAIAQDLLKD 150
AAAAKIILEV EIGVVGGEED GVAGEINEKL YTTPKDFVKT IDALGAGEHG 200
KYLLAATFGN VHGVYKPGNV KLRPDILAEG QKVAAAKLSQ SEGSKPFDFV 250
FHGGSGSEKS EIEEALRYGV VKMNVDTDTQ YAFTRPVSGH MFTNYDGVLK 300
VDGDVGNKKV YDPRSYLKKA EASMTERVLE ACNDLRCAGK SVAAS 345
Length:345
Mass (Da):36,741
Last modified:August 1, 1998 - v1
Checksum:i29FE8474C41D00C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL023514 Genomic DNA. Translation: CAA18950.1.
AL583918 Genomic DNA. Translation: CAC29794.1.
PIRiF86944.
RefSeqiNP_301326.1. NC_002677.1.
WP_010907650.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29794; CAC29794; CAC29794.
GeneIDi908824.
KEGGimle:ML0286.
PATRICi18051002. VBIMycLep78757_0450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL023514 Genomic DNA. Translation: CAA18950.1 .
AL583918 Genomic DNA. Translation: CAC29794.1 .
PIRi F86944.
RefSeqi NP_301326.1. NC_002677.1.
WP_010907650.1. NC_002677.1.

3D structure databases

ProteinModelPortali O69600.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272631.ML0286.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC29794 ; CAC29794 ; CAC29794 .
GeneIDi 908824.
KEGGi mle:ML0286.
PATRICi 18051002. VBIMycLep78757_0450.

Organism-specific databases

Lepromai ML0286.

Phylogenomic databases

eggNOGi COG0191.
HOGENOMi HOG000227794.
KOi K01624.
OMAi HNSLDFV.
OrthoDBi EOG69GZPB.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR006411. Fruct_bisP_bact.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
TIGRFAMsi TIGR00167. cbbA. 1 hit.
TIGR01520. FruBisAldo_II_A. 1 hit.
PROSITEi PS00602. ALDOLASE_CLASS_II_1. 1 hit.
PS00806. ALDOLASE_CLASS_II_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiALF_MYCLE
AccessioniPrimary (citable) accession number: O69600
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: September 3, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi