O69582 (COX3_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome aa3 subunit 3
Cytochrome c oxidase polypeptide III

Gene names

Name:	ctaE
Ordered Locus Names:	ML0882

Organism

Mycobacterium leprae (strain TN) [Complete proteome] [HAMAP]

Taxonomic identifier

272631 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium leprae

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 202	202	Probable cytochrome c oxidase subunit 3		PRO_0000183882
Regions
	Transmembrane	30 – 50	21	Helical; Potential
	Transmembrane	69 – 89	21	Helical; Potential
	Transmembrane	101 – 121	21	Helical; Potential
	Transmembrane	141 – 161	21	Helical; Potential
	Transmembrane	178 – 198	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	O69582 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 1BAB52B96C136B69	FASTA	202	22,377
	10 20 30 40 50 60 MTSTVGTLGT AITSRVHSLN RPNMVSVGTV VWLSSELMFF AGLFAMYFTA RAQAGGKWPP 70 80 90 100 110 120 STELNLYQAV PVTLVLIASS FTCQMGVFSA ERGDVFGLRR WYVITLLMGL FFVLGQGYEY 130 140 150 160 170 180 YHLITHGTTI PSSAYGSVFY LATGFHGLHV TGGLIAFIFL LARTTMSKFT PAQATASIVV 190 200 SYYWHFVDIV WIALFTVIYF IR

References

[1]

"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL022602 Genomic DNA. Translation: CAA18701.1. AL583920 Genomic DNA. Translation: CAC31263.1.
PIR	D87019.
RefSeq	NP_301668.1. NC_002677.1.
3D structure databases
ProteinModelPortal	O69582.
ModBase	Search...
Protein-protein interaction databases
STRING	272631.ML0882.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAC31263; CAC31263; CAC31263.
GeneID	909884.
KEGG	mle:ML0882.
PATRIC	18053336. VBIMycLep78757_1613.
Organism-specific databases
Leproma	ML0882.
CMR	Search...
Phylogenomic databases
eggNOG	COG1845.
HOGENOM	HOG000086399.
KO	K02276.
OMA	RMWFIVT.
ProtClustDB	CLSK872023.
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_MYCLE

Accession

Primary (citable) accession number: O69582

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	August 1, 1998
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program