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O69582

- COX3_MYCLE

UniProt

O69582 - COX3_MYCLE

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Protein

Probable cytochrome c oxidase subunit 3

Gene

ctaE

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. aerobic electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 3 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 3
Cytochrome c oxidase polypeptide III
Gene namesi
Name:ctaE
Ordered Locus Names:ML0882
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0882.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202Probable cytochrome c oxidase subunit 3PRO_0000183882Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0882.

Structurei

3D structure databases

ProteinModelPortaliO69582.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021HelicalSequence AnalysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence AnalysisAdd
BLAST
Transmembranei101 – 12121HelicalSequence AnalysisAdd
BLAST
Transmembranei141 – 16121HelicalSequence AnalysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1845.
HOGENOMiHOG000086399.
KOiK02276.
OMAiMEGDRKH.
OrthoDBiEOG6SFPBZ.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O69582-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSTVGTLGT AITSRVHSLN RPNMVSVGTV VWLSSELMFF AGLFAMYFTA
60 70 80 90 100
RAQAGGKWPP STELNLYQAV PVTLVLIASS FTCQMGVFSA ERGDVFGLRR
110 120 130 140 150
WYVITLLMGL FFVLGQGYEY YHLITHGTTI PSSAYGSVFY LATGFHGLHV
160 170 180 190 200
TGGLIAFIFL LARTTMSKFT PAQATASIVV SYYWHFVDIV WIALFTVIYF

IR
Length:202
Mass (Da):22,377
Last modified:August 1, 1998 - v1
Checksum:i1BAB52B96C136B69
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL022602 Genomic DNA. Translation: CAA18701.1.
AL583920 Genomic DNA. Translation: CAC31263.1.
PIRiD87019.
RefSeqiNP_301668.1. NC_002677.1.
WP_010907992.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31263; CAC31263; CAC31263.
GeneIDi909884.
KEGGimle:ML0882.
PATRICi18053336. VBIMycLep78757_1613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL022602 Genomic DNA. Translation: CAA18701.1 .
AL583920 Genomic DNA. Translation: CAC31263.1 .
PIRi D87019.
RefSeqi NP_301668.1. NC_002677.1.
WP_010907992.1. NC_002677.1.

3D structure databases

ProteinModelPortali O69582.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML0882.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC31263 ; CAC31263 ; CAC31263 .
GeneIDi 909884.
KEGGi mle:ML0882.
PATRICi 18053336. VBIMycLep78757_1613.

Organism-specific databases

Lepromai ML0882.

Phylogenomic databases

eggNOGi COG1845.
HOGENOMi HOG000086399.
KOi K02276.
OMAi MEGDRKH.
OrthoDBi EOG6SFPBZ.

Family and domain databases

Gene3Di 1.20.120.80. 1 hit.
InterProi IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view ]
PANTHERi PTHR11403. PTHR11403. 1 hit.
Pfami PF00510. COX3. 1 hit.
[Graphical view ]
SUPFAMi SSF81452. SSF81452. 1 hit.
PROSITEi PS50253. COX3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiCOX3_MYCLE
AccessioniPrimary (citable) accession number: O69582
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3