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Protein

Ribosomal RNA small subunit methyltransferase H

Gene

rsmH

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L-homocysteine + N(4)-methylcytosine(1402) in 16S rRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei97 – 971S-adenosyl-L-methionineUniRule annotation
Binding sitei124 – 1241S-adenosyl-L-methionine; via amide nitrogenUniRule annotation
Binding sitei148 – 1481S-adenosyl-L-methionineUniRule annotation
Binding sitei155 – 1551S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA small subunit methyltransferase HUniRule annotation (EC:2.1.1.199UniRule annotation)
Alternative name(s):
16S rRNA m(4)C1402 methyltransferaseUniRule annotation
rRNA (cytosine-N(4)-)-methyltransferase RsmHUniRule annotation
Gene namesi
Name:rsmHUniRule annotation
Synonyms:mraW
Ordered Locus Names:ML0906
ORF Names:MLCB268.10c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0906.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Ribosomal RNA small subunit methyltransferase HPRO_0000108660Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0906.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni78 – 803S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the methyltransferase superfamily. RsmH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGJ. Bacteria.
COG0275. LUCA.
HOGENOMiHOG000049778.
KOiK03438.
OMAiTHIPRSR.
OrthoDBiEOG6X9MQ1.

Family and domain databases

Gene3Di1.10.150.170. 1 hit.
3.40.50.150. 2 hits.
HAMAPiMF_01007. 16SrRNA_methyltr_H.
InterProiIPR002903. RsmH.
IPR023397. SAM-dep_MeTrfase_MraW_recog.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11265. PTHR11265. 1 hit.
PfamiPF01795. Methyltransf_5. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
SSF81799. SSF81799. 1 hit.
TIGRFAMsiTIGR00006. TIGR00006. 1 hit.

Sequencei

Sequence statusi: Complete.

O69560-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSDRDHDAG IFAFFGAVPR SDRCRQTRGG GEVVDGSSVF GHVPVFAQRC
60 70 80 90 100
VTLLAPALTR HHADGSNAIL VDATLGVGGH AERFLTEFPG LRLIGLDRDP
110 120 130 140 150
SALDIARTRL MRFADRVTLI HTRYDNLAVA LNKFGYAAVE SVDGVLFDLG
160 170 180 190 200
VSSMQLDCAE RGFSYAQDVP LDMRMDPWSP VSAADIVNNY DEAALADILR
210 220 230 240 250
RYGEERFARR IAAHIVRRRA HTPFTSTAEL VALLYQAIPA PARRIGGHPA
260 270 280 290 300
KRTFQALRIA VNDELNSLSN VLPAALDALT VAGRLVVLAY QSLEDRIVKR
310 320 330 340 350
VFADAVSSRT PAGLPIELPG HGPRFRLLTR GAEHADAAEI ECNPRSAAVR
360 370
LRALQRTQHG VEPQQPTRRG DS
Length:372
Mass (Da):40,606
Last modified:September 3, 2014 - v2
Checksum:i6E6542070B606108
GO

Sequence cautioni

The sequence CAA18676.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022602 Genomic DNA. Translation: CAA18676.1. Different initiation.
AL583920 Genomic DNA. Translation: CAC31287.1.
PIRiD87022.
RefSeqiNP_301689.1. NC_002677.1.
WP_010908013.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31287; CAC31287; CAC31287.
GeneIDi909902.
KEGGimle:ML0906.
PATRICi18053404. VBIMycLep78757_1647.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL022602 Genomic DNA. Translation: CAA18676.1. Different initiation.
AL583920 Genomic DNA. Translation: CAC31287.1.
PIRiD87022.
RefSeqiNP_301689.1. NC_002677.1.
WP_010908013.1. NC_002677.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0906.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC31287; CAC31287; CAC31287.
GeneIDi909902.
KEGGimle:ML0906.
PATRICi18053404. VBIMycLep78757_1647.

Organism-specific databases

LepromaiML0906.

Phylogenomic databases

eggNOGiENOG4105CGJ. Bacteria.
COG0275. LUCA.
HOGENOMiHOG000049778.
KOiK03438.
OMAiTHIPRSR.
OrthoDBiEOG6X9MQ1.

Family and domain databases

Gene3Di1.10.150.170. 1 hit.
3.40.50.150. 2 hits.
HAMAPiMF_01007. 16SrRNA_methyltr_H.
InterProiIPR002903. RsmH.
IPR023397. SAM-dep_MeTrfase_MraW_recog.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11265. PTHR11265. 1 hit.
PfamiPF01795. Methyltransf_5. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
SSF81799. SSF81799. 1 hit.
TIGRFAMsiTIGR00006. TIGR00006. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiRSMH_MYCLE
AccessioniPrimary (citable) accession number: O69560
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 3, 2014
Last modified: November 11, 2015
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.