Skip Header

Contribute Send feedback
Read comments (?) or add your own

O69555 (MRAY_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Synonyms:murX
Ordered Locus Names:ML0911
ORF Names:MLCB268.05c
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_0000108854

Regions

Transmembrane3 – 2321Helical; Potential
Transmembrane55 – 7521Helical; Potential
Transmembrane80 – 10021Helical; Potential
Transmembrane117 – 13721Helical; Potential
Transmembrane156 – 17621Helical; Potential
Transmembrane187 – 20721Helical; Potential
Transmembrane231 – 25121Helical; Potential
Transmembrane255 – 27521Helical; Potential
Transmembrane280 – 30021Helical; Potential
Transmembrane334 – 35421Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O69555 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 15554A306A3B4429

FASTA35937,773
        10         20         30         40         50         60 
MRQILVAVTV ALVVSILLTP ALIRLFTRHG FGQEIREDGP PSHHNKRGTP SMGGVAIVAG 

        70         80         90        100        110        120 
IWAGYLGTHL AGLAFDGEGV SASGVLVLGL ATALGGVGFL DDLIKIRRSR NLGLNKTAKT 

       130        140        150        160        170        180 
VGQITAAVLF GVLVLQFRNG AGLTPASADL SYVREIATVT LAPALFVLFC MVIVSAWSNA 

       190        200        210        220        230        240 
VNFTDGLDGL AAGSMAMVTA AYVLITFWQY RNACVTAPGL GCYNVRDPLD LTLIAAATVG 

       250        260        270        280        290        300 
ACIGFLWWNA APAKIFMGDT GSLALGGVIA GLSVTSRTEI LAVVLGSLFV AEITSVVLQI 

       310        320        330        340        350 
LAFRTTGRRV FRMAPFHHHF ELAGWAETTV IIRFWLLTAI ACGLGVVLFY GEWLATIGA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL022602 Genomic DNA. Translation: CAA18671.1.
AL583920 Genomic DNA. Translation: CAC31292.1.
PIRA87023.
RefSeqNP_301694.1. NC_002677.1.

3D structure databases

ProteinModelPortalO69555.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000028101; EBMYCP00000027707; EBMYCG00000028096.
GeneID909907.
GenomeReviewsGene locus ML0911 in contig AL450380_GR.
KEGGmle:ML0911.
NMPDRfig|272631.1.peg.566.
PATRIC18053418. VBIMycLep78757_1654.

Organism-specific databases

LepromaML0911.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016928.
HOGENOMHBG708263.
OMAAAGSMAM.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycMLEP272631:ML0911-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_MYCLE
AccessionPrimary (citable) accession number: O69555
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents