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O69552 (MURG_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
EC=2.4.1.227
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Gene names
Name:murG
Ordered Locus Names:ML0914
ORF Names:MLCB268.02c
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II) By similarity. HAMAP MF_00033

Catalytic activity

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00033

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00033

Subcellular location

Cell membrane; Peripheral membrane protein By similarity HAMAP MF_00033.

Sequence similarities

Belongs to the glycosyltransferase 28 family. MurG subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 407407UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase HAMAP MF_00033
PRO_0000109188

Sequences

Sequence LengthMass (Da)Tools
O69552 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: B757B73C092C53F9

FASTA40742,423
        10         20         30         40         50         60 
MNNSVREPTR GRRGSPPVAD AALSVNPPLS VVLAGGGTAG HVEPAMAVAD ALRALDPQVR 

        70         80         90        100        110        120 
ITALGTSRGL ETRLVPERGY HLELITPVPL PRKLTGDLAR LPLRVWRAVR ETRAVFEVVE 

       130        140        150        160        170        180 
AHVVVGFGGY VALPAYLAAR GIPRVRRRIP VVVHEANARA GIANRVGVRT AERVLSAVPG 

       190        200        210        220        230        240 
SGLRGAEVVG VPIHATITTL NRPALRADAR KHFGFTDDAR VLLVFGGSQG AVSLNRAVAG 

       250        260        270        280        290        300 
AAEDLAASGV AVLHAYGLKN TLELRTPEYG EPPYVAVPYL DRMDLAYAAA DLVICRSGAM 

       310        320        330        340        350        360 
TVAEVSAVGL PAIYVPFPIG NGEQRLNALP VVNAGGGLVV ADADLTPGLV ARQVVRLFSD 

       370        380        390        400 
PAQLAAMTAA AARVGHRDAA HHVAKVALDL ARAERDTASG RSAGGKP

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL022602 Genomic DNA. Translation: CAA18668.1.
AL583920 Genomic DNA. Translation: CAC31295.1.
PIRD87023.
RefSeqNP_301697.1. NC_002677.1.

3D structure databases

ProteinModelPortalO69552.
ModBaseSearch...

Protein family/group databases

CAZyGT28. Glycosyltransferase Family 28.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000028547; EBMYCP00000028153; EBMYCG00000028542.
GeneID909917.
GenomeReviewsGene locus ML0914 in contig AL450380_GR.
KEGGmle:ML0914.
NMPDRfig|272631.1.peg.569.
PATRIC18053424. VBIMycLep78757_1657.

Organism-specific databases

LepromaML0914.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000016957.
HOGENOMHBG617076.
OMAVPLPHGN.
ProtClustDBPRK00726.

Enzyme and pathway databases

BioCycMLEP272631:ML0914-MONOMER.

Family and domain databases

HAMAPMF_00033. MurG.
[Tree]
InterProIPR006009. GlcNAc_MurG.
IPR004276. Glyco_trans_28.
IPR007235. Glyco_trans_28_C.
[Graphical view]
KOK02563.
PANTHERPTHR21015:SF22. PTHR21015:SF22. 1 hit.
PfamPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsTIGR01133. MurG. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURG_MYCLE
AccessionPrimary (citable) accession number: O69552
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: January 25, 2012
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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