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Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.

Cofactori

Mg2+By similarityNote: Binds 4 Mg2+ ions per subunit. Other metal ions can support activity, but at a lower rate. Two Mg2+ ions are required for the activation of the enzyme and are present before substrate binds, two additional Mg2+ ions form complexes with substrate and product.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi52 – 521Magnesium 1By similarity
Metal bindingi57 – 571Magnesium 1By similarity
Metal bindingi57 – 571Magnesium 2By similarity
Metal bindingi89 – 891Magnesium 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphatase (EC:3.6.1.1)
Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name:
PPase
Gene namesi
Name:ppa
Ordered Locus Names:ML0210
ORF Names:MLCB2548.21
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0210.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 162162Inorganic pyrophosphatasePRO_0000137511Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML0210.

Structurei

Secondary structure

1
162
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 97Combined sources
Beta strandi15 – 195Combined sources
Turni21 – 233Combined sources
Beta strandi26 – 316Combined sources
Beta strandi33 – 364Combined sources
Beta strandi39 – 457Combined sources
Beta strandi57 – 604Combined sources
Beta strandi71 – 8414Combined sources
Beta strandi87 – 9812Combined sources
Helixi100 – 1023Combined sources
Helixi108 – 1103Combined sources
Helixi113 – 12513Combined sources
Turni126 – 1294Combined sources
Beta strandi135 – 1428Combined sources
Helixi143 – 15816Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4ECPX-ray1.80A/B2-162[»]
ProteinModelPortaliO69540.
SMRiO69540. Positions 1-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.Curated

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
HOGENOMiHOG000236473.
KOiK01507.
OMAiDGVANYK.
OrthoDBiEOG6NKR4X.

Family and domain databases

Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O69540-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFDVTIEIP KGQRNKYEVD HKTGRVRLDR YLYTPMAYPT DYGFIEDTLG
60 70 80 90 100
EDGDPLDALV LLPEPLFPGV LVEARPVGMF RMVDEHGGDD KVLCVPVNDH
110 120 130 140 150
RWDHIHGIID VPTFELDAIK HFFVHYKDLE PGKFVKAADW VGRDEAEAEV
160
QRSVERFKAG GH
Length:162
Mass (Da):18,533
Last modified:August 1, 1998 - v1
Checksum:i5458700F5C26FEC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL023093 Genomic DNA. Translation: CAA18808.1.
AL583917 Genomic DNA. Translation: CAC29718.1.
PIRiB86935.
RefSeqiNP_301276.1. NC_002677.1.
WP_010907600.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29718; CAC29718; CAC29718.
GeneIDi908623.
KEGGimle:ML0210.
PATRICi18050768. VBIMycLep78757_0335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL023093 Genomic DNA. Translation: CAA18808.1.
AL583917 Genomic DNA. Translation: CAC29718.1.
PIRiB86935.
RefSeqiNP_301276.1. NC_002677.1.
WP_010907600.1. NC_002677.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4ECPX-ray1.80A/B2-162[»]
ProteinModelPortaliO69540.
SMRiO69540. Positions 1-160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0210.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC29718; CAC29718; CAC29718.
GeneIDi908623.
KEGGimle:ML0210.
PATRICi18050768. VBIMycLep78757_0335.

Organism-specific databases

LepromaiML0210.

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
HOGENOMiHOG000236473.
KOiK01507.
OMAiDGVANYK.
OrthoDBiEOG6NKR4X.

Family and domain databases

Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiIPYR_MYCLE
AccessioniPrimary (citable) accession number: O69540
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: November 11, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.