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Protein

Inorganic pyrophosphatase

Gene

ppa

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.UniRule annotation

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8Magnesium 2UniRule annotation1
Binding sitei16SubstrateUniRule annotation1
Binding sitei30SubstrateUniRule annotation1
Binding sitei42SubstrateUniRule annotation1
Metal bindingi52Magnesium 1UniRule annotation1
Metal bindingi57Magnesium 1UniRule annotation1
Metal bindingi57Magnesium 2UniRule annotation1
Metal bindingi84Magnesium 3UniRule annotation1
Active sitei89Proton acceptorUniRule annotation1
Metal bindingi89Magnesium 1UniRule annotation1
Metal bindingi89Magnesium 3UniRule annotation1
Binding sitei126SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaUniRule annotation
Ordered Locus Names:ML0210
ORF Names:MLCB2548.21
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML0210.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001375111 – 162Inorganic pyrophosphataseAdd BLAST162

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML0210.

Structurei

Secondary structure

1162
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 9Combined sources7
Beta strandi15 – 19Combined sources5
Turni21 – 23Combined sources3
Beta strandi26 – 31Combined sources6
Beta strandi33 – 36Combined sources4
Beta strandi39 – 45Combined sources7
Beta strandi57 – 60Combined sources4
Beta strandi71 – 84Combined sources14
Beta strandi87 – 98Combined sources12
Helixi100 – 102Combined sources3
Helixi108 – 110Combined sources3
Helixi113 – 125Combined sources13
Turni126 – 129Combined sources4
Beta strandi135 – 142Combined sources8
Helixi143 – 158Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ECPX-ray1.80A/B2-162[»]
ProteinModelPortaliO69540.
SMRiO69540.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
HOGENOMiHOG000236473.
KOiK01507.
OMAiDGVANYK.
OrthoDBiPOG091H05Q5.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O69540-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFDVTIEIP KGQRNKYEVD HKTGRVRLDR YLYTPMAYPT DYGFIEDTLG
60 70 80 90 100
EDGDPLDALV LLPEPLFPGV LVEARPVGMF RMVDEHGGDD KVLCVPVNDH
110 120 130 140 150
RWDHIHGIID VPTFELDAIK HFFVHYKDLE PGKFVKAADW VGRDEAEAEV
160
QRSVERFKAG GH
Length:162
Mass (Da):18,533
Last modified:August 1, 1998 - v1
Checksum:i5458700F5C26FEC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL023093 Genomic DNA. Translation: CAA18808.1.
AL583917 Genomic DNA. Translation: CAC29718.1.
PIRiB86935.
RefSeqiNP_301276.1. NC_002677.1.
WP_010907600.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29718; CAC29718; CAC29718.
GeneIDi908623.
KEGGimle:ML0210.
PATRICi18050768. VBIMycLep78757_0335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL023093 Genomic DNA. Translation: CAA18808.1.
AL583917 Genomic DNA. Translation: CAC29718.1.
PIRiB86935.
RefSeqiNP_301276.1. NC_002677.1.
WP_010907600.1. NC_002677.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ECPX-ray1.80A/B2-162[»]
ProteinModelPortaliO69540.
SMRiO69540.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML0210.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC29718; CAC29718; CAC29718.
GeneIDi908623.
KEGGimle:ML0210.
PATRICi18050768. VBIMycLep78757_0335.

Organism-specific databases

LepromaiML0210.

Phylogenomic databases

eggNOGiENOG4105F0N. Bacteria.
COG0221. LUCA.
HOGENOMiHOG000236473.
KOiK01507.
OMAiDGVANYK.
OrthoDBiPOG091H05Q5.

Family and domain databases

CDDicd00412. pyrophosphatase. 1 hit.
Gene3Di3.90.80.10. 1 hit.
HAMAPiMF_00209. Inorganic_PPase. 1 hit.
InterProiIPR008162. Pyrophosphatase.
[Graphical view]
PANTHERiPTHR10286. PTHR10286. 1 hit.
PfamiPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF50324. SSF50324. 1 hit.
PROSITEiPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIPYR_MYCLE
AccessioniPrimary (citable) accession number: O69540
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.