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O69537 (HPRT_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hypoxanthine-guanine phosphoribosyltransferase

Short name=HGPRT
Short name=HGPRTase
EC=2.4.2.8
Gene names
Name:hpt
Synonyms:hprT
Ordered Locus Names:ML0214
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.

GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.

Cofactor

Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein By similarity.

Pathway

Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Sequence caution

The sequence CAA18804.1 differs from that shown. Reason: Erroneous initiation.

The sequence CAC29722.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processPurine salvage
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
Nucleotide-binding
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processIMP salvage

Inferred from electronic annotation. Source: UniProtKB-UniPathway

purine ribonucleoside salvage

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionguanine phosphoribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

hypoxanthine phosphoribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

nucleotide binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 203203Hypoxanthine-guanine phosphoribosyltransferase
PRO_0000139608

Regions

Nucleotide binding122 – 13110IMP By similarity
Nucleotide binding181 – 1822IMP By similarity

Sites

Active site1261Proton acceptor By similarity
Metal binding1821Magnesium By similarity
Binding site1541IMP By similarity
Binding site1761IMP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
O69537 [UniParc].

Last modified August 29, 2001. Version 2.
Checksum: AC9133B56D09EC7A

FASTA20322,665
        10         20         30         40         50         60 
MLVAQSFSAI NPGPTAELYL GDIKSVMLTQ EQIQARIAEL GAQIGHDYRD RSPASDQDLL 

        70         80         90        100        110        120 
LVTVLKGAVI FVTDLARAIP LPTQFEFMAV SSYGSSMSSS GVVRILKDLD RDIHDRNVLI 

       130        140        150        160        170        180 
VEDVVDSGLT LSWLLRNLAT RRPQSLQVCT LLRKPDALRA NVDITYVGFD IPNDFVVGYG 

       190        200 
LDYDERYRDL PYIGMLDPRV YQQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL023093 Genomic DNA. Translation: CAA18804.1. Different initiation.
AL583917 Genomic DNA. Translation: CAC29722.1. Different initiation.
PIRF86935.
RefSeqNP_301279.1. NC_002677.1.

3D structure databases

ProteinModelPortalO69537.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML0214.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC29722; CAC29722; CAC29722.
GeneID909576.
KEGGmle:ML0214.
PATRIC18050778. VBIMycLep78757_0340.

Organism-specific databases

LepromaML0214.
CMRSearch...

Phylogenomic databases

eggNOGCOG0634.
HOGENOMHOG000236520.
KOK00760.
OrthoDBEOG693GNP.

Enzyme and pathway databases

UniPathwayUPA00591; UER00648.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
InterProIPR005904. Hxn_phspho_trans.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
TIGRFAMsTIGR01203. HGPRTase. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHPRT_MYCLE
AccessionPrimary (citable) accession number: O69537
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: August 29, 2001
Last modified: June 11, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways