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O69537

- HPRT_MYCLE

UniProt

O69537 - HPRT_MYCLE

Protein

Hypoxanthine-guanine phosphoribosyltransferase

Gene

hpt

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 2 (29 Aug 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.
    GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.

    Cofactori

    Binds 2 magnesium ions per subunit. The magnesium ions are essentially bound to the substrate and have few direct interactions with the protein By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei126 – 1261Proton acceptorBy similarity
    Binding sitei154 – 1541IMPBy similarity
    Binding sitei176 – 1761IMP; via carbonyl oxygenBy similarity
    Metal bindingi182 – 1821MagnesiumBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi122 – 13110IMPBy similarity
    Nucleotide bindingi181 – 1822IMPBy similarity

    GO - Molecular functioni

    1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
    2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW
    4. nucleotide binding Source: UniProtKB-KW

    GO - Biological processi

    1. IMP salvage Source: UniProtKB-UniPathway
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Keywords - Ligandi

    Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00591; UER00648.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hypoxanthine-guanine phosphoribosyltransferase (EC:2.4.2.8)
    Short name:
    HGPRT
    Short name:
    HGPRTase
    Gene namesi
    Name:hpt
    Synonyms:hprT
    Ordered Locus Names:ML0214
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML0214.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 203203Hypoxanthine-guanine phosphoribosyltransferasePRO_0000139608Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272631.ML0214.

    Structurei

    3D structure databases

    ProteinModelPortaliO69537.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0634.
    HOGENOMiHOG000236520.
    KOiK00760.
    OrthoDBiEOG693GNP.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    InterProiIPR005904. Hxn_phspho_trans.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view]
    PfamiPF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.
    TIGRFAMsiTIGR01203. HGPRTase. 1 hit.
    PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O69537-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLVAQSFSAI NPGPTAELYL GDIKSVMLTQ EQIQARIAEL GAQIGHDYRD    50
    RSPASDQDLL LVTVLKGAVI FVTDLARAIP LPTQFEFMAV SSYGSSMSSS 100
    GVVRILKDLD RDIHDRNVLI VEDVVDSGLT LSWLLRNLAT RRPQSLQVCT 150
    LLRKPDALRA NVDITYVGFD IPNDFVVGYG LDYDERYRDL PYIGMLDPRV 200
    YQQ 203
    Length:203
    Mass (Da):22,665
    Last modified:August 29, 2001 - v2
    Checksum:iAC9133B56D09EC7A
    GO

    Sequence cautioni

    The sequence CAA18804.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAC29722.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL023093 Genomic DNA. Translation: CAA18804.1. Different initiation.
    AL583917 Genomic DNA. Translation: CAC29722.1. Different initiation.
    PIRiF86935.
    RefSeqiNP_301279.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC29722; CAC29722; CAC29722.
    GeneIDi909576.
    KEGGimle:ML0214.
    PATRICi18050778. VBIMycLep78757_0340.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL023093 Genomic DNA. Translation: CAA18804.1 . Different initiation.
    AL583917 Genomic DNA. Translation: CAC29722.1 . Different initiation.
    PIRi F86935.
    RefSeqi NP_301279.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali O69537.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML0214.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC29722 ; CAC29722 ; CAC29722 .
    GeneIDi 909576.
    KEGGi mle:ML0214.
    PATRICi 18050778. VBIMycLep78757_0340.

    Organism-specific databases

    Lepromai ML0214.

    Phylogenomic databases

    eggNOGi COG0634.
    HOGENOMi HOG000236520.
    KOi K00760.
    OrthoDBi EOG693GNP.

    Enzyme and pathway databases

    UniPathwayi UPA00591 ; UER00648 .

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    InterProi IPR005904. Hxn_phspho_trans.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view ]
    Pfami PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    TIGRFAMsi TIGR01203. HGPRTase. 1 hit.
    PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiHPRT_MYCLE
    AccessioniPrimary (citable) accession number: O69537
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2001
    Last sequence update: August 29, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3