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O69529 (FOLB_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable dihydroneopterin aldolase
Short name=DHNA
EC=4.1.2.25
Gene names
Name:folB
Ordered Locus Names:ML0225
ORF Names:MLCB2548.06c
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length132 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin By similarity.

Catalytic activity

2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.

Sequence similarities

Belongs to the DHNA family.

Ontologies

Keywords
   Biological processFolate biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processfolic acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functiondihydroneopterin aldolase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 132132Probable dihydroneopterin aldolase
PRO_0000168274

Sequences

Sequence LengthMass (Da)Tools
O69529 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: B93663D838044DD0

FASTA13214,449
        10         20         30         40         50         60 
MADRMELRGL IVRGRHGVYE VERANGQDFI VDVILWIDLA DAAANDNLAD TYDYVVLAER 

        70         80         90        100        110        120 
TAAIIAGPPR NLIETVGSEI ADFVMDDERV HAVEVVVHKP QAPIPQQFSD VAVVVRRSRR 

       130 
GGRGSMIPAS GV

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL023093 Genomic DNA. Translation: CAA18793.1.
AL583917 Genomic DNA. Translation: CAC29733.1.
PIRA86937.
RefSeqNP_301285.1. NC_002677.1.

3D structure databases

ProteinModelPortalO69529.
SMRO69529. Positions 2-119.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000029405; EBMYCP00000029011; EBMYCG00000029400.
GeneID908411.
GenomeReviewsGene locus ML0225 in contig AL450380_GR.
KEGGmle:ML0225.
NMPDRfig|272631.1.peg.157.
PATRIC18050812. VBIMycLep78757_0357.

Organism-specific databases

LepromaML0225.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000017251.
HOGENOMHBG635896.
OMAAPIPDFG.
ProtClustDBCLSK799351.

Enzyme and pathway databases

BioCycMLEP272631:ML0225-MONOMER.

Family and domain databases

InterProIPR006156. Dihydroneopterin_aldolase.
IPR006157. FolB_dom.
[Graphical view]
KOK01633.
PANTHERPTHR20941:SF3. FolB. 1 hit.
PfamPF02152. FolB. 1 hit.
[Graphical view]
SMARTSM00905. FolB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00525. FolB. 1 hit.
TIGR00526. FolB_dom. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFOLB_MYCLE
AccessionPrimary (citable) accession number: O69529
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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