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O69524 (PANC_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pantothenate synthetase

Short name=PS
EC=6.3.2.1
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene names
Name:panC
Ordered Locus Names:ML0230
ORF Names:MLCB2548.01c
OrganismMycobacterium leprae (strain TN) [Complete proteome] [HAMAP]
Taxonomic identifier272631 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity. HAMAP-Rule MF_00158

Catalytic activity

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP-Rule MF_00158

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP-Rule MF_00158

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00158

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00158.

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Sequence similarities

Belongs to the pantothenate synthetase family.

Ontologies

Keywords
   Biological processPantothenate biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpantothenate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

pantoate-beta-alanine ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Pantothenate synthetase HAMAP-Rule MF_00158
PRO_0000128243

Regions

Nucleotide binding43 – 508ATP By similarity
Nucleotide binding161 – 1644ATP By similarity
Nucleotide binding198 – 2014ATP By similarity

Sites

Active site501Proton donor By similarity
Binding site751Beta-alanine By similarity
Binding site751Pantoate By similarity
Binding site1671Pantoate By similarity
Binding site1901ATP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
O69524 [UniParc].

Last modified April 27, 2001. Version 2.
Checksum: 0209C216EB26A712

FASTA31333,586
        10         20         30         40         50         60 
MTNSRQPAFN PGELNVYSTP RDVTNVSSAL RHTGRRVMLV PTMGALHNGH LALVRAAKRV 

        70         80         90        100        110        120 
PGSVVVVSIF VNPLQFGAAE DLDTYPCTFD DDLALLRAED VEIVFTPTAA AMYPHGLRTT 

       130        140        150        160        170        180 
VRPGALAFEL EGGPRPNHFD GVLTVVLKLL QIVRPDRVFF GEKDYQQLVL IRQMVADLNV 

       190        200        210        220        230        240 
DVVVVGVPTV REVDGLAMSS RNCYLDPVQR DLAAALSAAL TAGAHAATGG AQAALDAARA 

       250        260        270        280        290        300 
VLDATPGLVV DYVELRDAGL GPMRDNTFGR LLVAARLGAT RLLDNISIEI GNFSGIASPD 

       310 
ECRVEHAQTP WMK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL583917 Genomic DNA. Translation: CAC29738.1.
AL023093 Genomic DNA. Translation: CAA18788.1.
PIRF86937.
RefSeqNP_301290.1. NC_002677.1.

3D structure databases

ProteinModelPortalO69524.
SMRO69524. Positions 7-294.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272631.ML0230.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC29738; CAC29738; CAC29738.
GeneID908653.
KEGGmle:ML0230.
PATRIC18050824. VBIMycLep78757_0363.

Organism-specific databases

LepromaML0230.
CMRSearch...

Phylogenomic databases

eggNOGCOG0414.
HOGENOMHOG000175516.
KOK01918.
OMAIVRDSDH.
OrthoDBEOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayUPA00028; UER00005.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00158. PanC.
InterProIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00018. panC. 1 hit.
ProtoNetSearch...

Entry information

Entry namePANC_MYCLE
AccessionPrimary (citable) accession number: O69524
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 27, 2001
Last modified: June 11, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways