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O69524

- PANC_MYCLE

UniProt

O69524 - PANC_MYCLE

Protein

Pantothenate synthetase

Gene

panC

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (27 Apr 2001)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei50 – 501Proton donorUniRule annotation
    Binding sitei75 – 751Beta-alanineUniRule annotation
    Binding sitei75 – 751PantoateUniRule annotation
    Binding sitei167 – 1671PantoateUniRule annotation
    Binding sitei190 – 1901ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi43 – 508ATPUniRule annotation
    Nucleotide bindingi161 – 1644ATPUniRule annotation
    Nucleotide bindingi198 – 2014ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Gene namesi
    Name:panCUniRule annotation
    Ordered Locus Names:ML0230
    ORF Names:MLCB2548.01c
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML0230.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 313313Pantothenate synthetasePRO_0000128243Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272631.ML0230.

    Structurei

    3D structure databases

    ProteinModelPortaliO69524.
    SMRiO69524. Positions 7-294.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    HOGENOMiHOG000175516.
    KOiK01918.
    OMAiIVRDSDH.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O69524-1 [UniParc]FASTAAdd to Basket

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    MTNSRQPAFN PGELNVYSTP RDVTNVSSAL RHTGRRVMLV PTMGALHNGH    50
    LALVRAAKRV PGSVVVVSIF VNPLQFGAAE DLDTYPCTFD DDLALLRAED 100
    VEIVFTPTAA AMYPHGLRTT VRPGALAFEL EGGPRPNHFD GVLTVVLKLL 150
    QIVRPDRVFF GEKDYQQLVL IRQMVADLNV DVVVVGVPTV REVDGLAMSS 200
    RNCYLDPVQR DLAAALSAAL TAGAHAATGG AQAALDAARA VLDATPGLVV 250
    DYVELRDAGL GPMRDNTFGR LLVAARLGAT RLLDNISIEI GNFSGIASPD 300
    ECRVEHAQTP WMK 313
    Length:313
    Mass (Da):33,586
    Last modified:April 27, 2001 - v2
    Checksum:i0209C216EB26A712
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL583917 Genomic DNA. Translation: CAC29738.1.
    AL023093 Genomic DNA. Translation: CAA18788.1.
    PIRiF86937.
    RefSeqiNP_301290.1. NC_002677.1.
    WP_010907614.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC29738; CAC29738; CAC29738.
    GeneIDi908653.
    KEGGimle:ML0230.
    PATRICi18050824. VBIMycLep78757_0363.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL583917 Genomic DNA. Translation: CAC29738.1 .
    AL023093 Genomic DNA. Translation: CAA18788.1 .
    PIRi F86937.
    RefSeqi NP_301290.1. NC_002677.1.
    WP_010907614.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali O69524.
    SMRi O69524. Positions 7-294.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML0230.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC29738 ; CAC29738 ; CAC29738 .
    GeneIDi 908653.
    KEGGi mle:ML0230.
    PATRICi 18050824. VBIMycLep78757_0363.

    Organism-specific databases

    Lepromai ML0230.

    Phylogenomic databases

    eggNOGi COG0414.
    HOGENOMi HOG000175516.
    KOi K01918.
    OMAi IVRDSDH.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiPANC_MYCLE
    AccessioniPrimary (citable) accession number: O69524
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3