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O69524

- PANC_MYCLE

UniProt

O69524 - PANC_MYCLE

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Protein
Pantothenate synthetase
Gene
panC, ML0230, MLCB2548.01c
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei50 – 501Proton donor By similarity
Binding sitei75 – 751Beta-alanine By similarity
Binding sitei75 – 751Pantoate By similarity
Binding sitei167 – 1671Pantoate By similarity
Binding sitei190 – 1901ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi43 – 508ATP By similarity
Nucleotide bindingi161 – 1644ATP By similarity
Nucleotide bindingi198 – 2014ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase (EC:6.3.2.1)
Short name:
PS
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene namesi
Name:panC
Ordered Locus Names:ML0230
ORF Names:MLCB2548.01c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML0230.

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Pantothenate synthetaseUniRule annotation
PRO_0000128243Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML0230.

Structurei

3D structure databases

ProteinModelPortaliO69524.
SMRiO69524. Positions 7-294.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiIVRDSDH.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

O69524-1 [UniParc]FASTAAdd to Basket

« Hide

MTNSRQPAFN PGELNVYSTP RDVTNVSSAL RHTGRRVMLV PTMGALHNGH    50
LALVRAAKRV PGSVVVVSIF VNPLQFGAAE DLDTYPCTFD DDLALLRAED 100
VEIVFTPTAA AMYPHGLRTT VRPGALAFEL EGGPRPNHFD GVLTVVLKLL 150
QIVRPDRVFF GEKDYQQLVL IRQMVADLNV DVVVVGVPTV REVDGLAMSS 200
RNCYLDPVQR DLAAALSAAL TAGAHAATGG AQAALDAARA VLDATPGLVV 250
DYVELRDAGL GPMRDNTFGR LLVAARLGAT RLLDNISIEI GNFSGIASPD 300
ECRVEHAQTP WMK 313
Length:313
Mass (Da):33,586
Last modified:April 27, 2001 - v2
Checksum:i0209C216EB26A712
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL583917 Genomic DNA. Translation: CAC29738.1.
AL023093 Genomic DNA. Translation: CAA18788.1.
PIRiF86937.
RefSeqiNP_301290.1. NC_002677.1.
WP_010907614.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC29738; CAC29738; CAC29738.
GeneIDi908653.
KEGGimle:ML0230.
PATRICi18050824. VBIMycLep78757_0363.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL583917 Genomic DNA. Translation: CAC29738.1 .
AL023093 Genomic DNA. Translation: CAA18788.1 .
PIRi F86937.
RefSeqi NP_301290.1. NC_002677.1.
WP_010907614.1. NC_002677.1.

3D structure databases

ProteinModelPortali O69524.
SMRi O69524. Positions 7-294.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML0230.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC29738 ; CAC29738 ; CAC29738 .
GeneIDi 908653.
KEGGi mle:ML0230.
PATRICi 18050824. VBIMycLep78757_0363.

Organism-specific databases

Lepromai ML0230.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi IVRDSDH.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiPANC_MYCLE
AccessioniPrimary (citable) accession number: O69524
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 27, 2001
Last modified: September 3, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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