O69497 (GABD1_MYCLE) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 74.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Succinate-semialdehyde dehydrogenase [NADP+] Short name=SSADH Short name=SSDH EC=1.2.1.79 | ||||||
| Gene names |
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| Organism | Mycobacterium leprae [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1769 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium |
Protein attributes
| Sequence length | 457 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the NADP+-dependent oxidation of succinate semialdehyde to succinate. It is believed to be the main source of succinate semialdehyde dehydrogenase activity in Mycobacterium By similarity. |
| Catalytic activity | Succinate semialdehyde + NADP+ + H2O = succinate + NADPH. |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Tricarboxylic acid cycle |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 457 | 457 | Succinate-semialdehyde dehydrogenase [NADP+] | PRO_0000310703 | |||||
Regions | |||||||||
| Nucleotide binding | 133 – 134 | 2 | NADP By similarity | ||||||
| Nucleotide binding | 157 – 160 | 4 | NADP By similarity | ||||||
| Nucleotide binding | 209 – 210 | 2 | NADP By similarity | ||||||
Sites | |||||||||
| Active site | 231 | 1 | Proton acceptor By similarity | ||||||
| Active site | 265 | 1 | Nucleophile By similarity | ||||||
| Binding site | 232 | 1 | NADP; via carbonyl oxygen By similarity | ||||||
| Binding site | 362 | 1 | NADP By similarity | ||||||
Sequences
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References
| [1] | "Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. Barrell B.G.Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL022486 Genomic DNA. Translation: CAA18560.1. AL583926 Genomic DNA. Translation: CAC32105.1. |
| PIR | T44871. |
| RefSeq | NP_302648.1. NC_002677.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1WND based on UniProtKB P77674. |
| ProteinModelPortal | O69497. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBMYCT00000028888; EBMYCP00000028494; EBMYCG00000028883. |
| GeneID | 910883. |
| GenomeReviews | Gene locus ML2573 in contig AL450380_GR. |
| KEGG | mle:ML2573. |
| NMPDR | fig|272631.1.peg.1520. |
| PATRIC | 18060063. VBIMycLep78757_4945. |
Organism-specific databases | |
| Leproma | ML2573. |
| CMR | Search... |
Phylogenomic databases | |
| GeneTree | EBGT00050000015659. |
| HOGENOM | HBG752218. |
| OMA | VPQSALY. |
| ProtClustDB | PRK09406. |
Enzyme and pathway databases | |
| BioCyc | MLEP272631:ML2573-MONOMER. |
Family and domain databases | |
| InterPro | IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit. |
| KO | K00135. |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| SUPFAM | SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit. |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GABD1_MYCLE | ||||||||
| Accession | Primary (citable) accession number: O69497 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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