Reviewed, UniProtKB/Swiss-Prot O69497 (GABD1_MYCLE)

Names and origin

Protein names

Recommended name:
    Succinate-semialdehyde dehydrogenase [NADP+]
      Short name=SSADH
      Short name=SSDH
    EC=1.2.1.16

Gene names

Name:	gabD1
Ordered Locus Names:	ML2573
ORF Names:	MLCB1883.11c

Organism

Mycobacterium leprae [Complete proteome] [HAMAP]

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	457 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate. It is believed to be the main source of succinate semialdehyde dehydrogenase activity in Mycobacterium By similarity.
Catalytic activity	Succinate semialdehyde + NAD(P)(+) + H(2)O = succinate + NAD(P)H.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinate-semialdehyde dehydrogenase [NAD(P)+] activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 457	457	Succinate-semialdehyde dehydrogenase [NADP+]		PRO_0000310703
Regions
	Nucleotide binding	209 – 214	6	NAD or NADP By similarity
Sites
	Active site	231	1	By similarity
	Active site	265	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O69497-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 1EEF6444A6DD13BD	FASTA	457	48,879
	10 20 30 40 50 60 MSIATINPAT GETVKTFTPT TQDEVEDAIA RAYARFDNYR HTTFTQRAKW ANATADLLEA 70 80 90 100 110 120 EANQSAALMT LEMGKTLQSA KDEAMKCAKG FRYYAEKAET LLADEPAEAA AVGASKALAR 130 140 150 160 170 180 YQPLGVVLAV MPWNFPLWQT VRFAAPALMA GNVGLLKHAS NVPQCALYLA DVIARGGFPE 190 200 210 220 230 240 DCFQTLLISA NGVEAILRDP RVAAATLTGS EPAGQAVGAI AGNEIKPTVL ELGGSDPFIV 250 260 270 280 290 300 MPSADLDAAV ATAVTGRVQN NGQSCIAAKR FIAHADIYDE FVEKFVARME TLRVGDPTDP 310 320 330 340 350 360 DTDVGPLATE SGRAQVEQQV DAAAAAGAVI RCGGKRPDRP GWFYPPTVIT DITKDMALYT 370 380 390 400 410 420 DEVFGPVASV YCATNIDDAI EIANATPFGL GSNAWTQNES EQRHFIDNIV AGQVFINGMT 430 440 450 VSYPELPFGG IKRSGYGREL STHGIREFCN IKTVWIA

References

[1]

"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL022486 Genomic DNA. Translation: CAA18560.1. AL583926 Genomic DNA. Translation: CAC32105.1.
PIR	T44871.
RefSeq	NP_302648.1.
3D structure databases
HSSP	HSSP built from PDB template 1O04 based on UniProtKB P05091.
ModBase	Search...
Genome annotation databases
GeneID	910883.
GenomeReviews	Gene locus ML2573 in contig AL450380_GR.
KEGG	mle:ML2573.
NMPDR	fig|272631.1.peg.1520.
Organism-specific databases
Leproma	ML2573.
CMR	Search...
Phylogenomic databases
HOGENOM	O69497.
Enzyme and pathway databases
BioCyc	MLEP272631:ML2573-MON.
Family and domain databases
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GABD1_MYCLE

Accession

Primary (citable) accession number: O69497

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	August 1, 1998
Last modified:	November 4, 2008
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)