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O69497 (GABD1_MYCLE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Succinate-semialdehyde dehydrogenase [NADP+]
Short name=SSADH
Short name=SSDH
EC=1.2.1.79
Gene names
Name:gabD1
Ordered Locus Names:ML2573
ORF Names:MLCB1883.11c
OrganismMycobacterium leprae [Complete proteome] [HAMAP]
Taxonomic identifier1769 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP+-dependent oxidation of succinate semialdehyde to succinate. It is believed to be the main source of succinate semialdehyde dehydrogenase activity in Mycobacterium By similarity.

Catalytic activity

Succinate semialdehyde + NADP+ + H2O = succinate + NADPH.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457Succinate-semialdehyde dehydrogenase [NADP+]
PRO_0000310703

Regions

Nucleotide binding133 – 1342NADP By similarity
Nucleotide binding157 – 1604NADP By similarity
Nucleotide binding209 – 2102NADP By similarity

Sites

Active site2311Proton acceptor By similarity
Active site2651Nucleophile By similarity
Binding site2321NADP; via carbonyl oxygen By similarity
Binding site3621NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
O69497 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 1EEF6444A6DD13BD

FASTA45748,879
        10         20         30         40         50         60 
MSIATINPAT GETVKTFTPT TQDEVEDAIA RAYARFDNYR HTTFTQRAKW ANATADLLEA 

        70         80         90        100        110        120 
EANQSAALMT LEMGKTLQSA KDEAMKCAKG FRYYAEKAET LLADEPAEAA AVGASKALAR 

       130        140        150        160        170        180 
YQPLGVVLAV MPWNFPLWQT VRFAAPALMA GNVGLLKHAS NVPQCALYLA DVIARGGFPE 

       190        200        210        220        230        240 
DCFQTLLISA NGVEAILRDP RVAAATLTGS EPAGQAVGAI AGNEIKPTVL ELGGSDPFIV 

       250        260        270        280        290        300 
MPSADLDAAV ATAVTGRVQN NGQSCIAAKR FIAHADIYDE FVEKFVARME TLRVGDPTDP 

       310        320        330        340        350        360 
DTDVGPLATE SGRAQVEQQV DAAAAAGAVI RCGGKRPDRP GWFYPPTVIT DITKDMALYT 

       370        380        390        400        410        420 
DEVFGPVASV YCATNIDDAI EIANATPFGL GSNAWTQNES EQRHFIDNIV AGQVFINGMT 

       430        440        450 
VSYPELPFGG IKRSGYGREL STHGIREFCN IKTVWIA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL022486 Genomic DNA. Translation: CAA18560.1.
AL583926 Genomic DNA. Translation: CAC32105.1.
PIRT44871.
RefSeqNP_302648.1. NC_002677.1.

3D structure databases

HSSPHSSP built from PDB template 1WND based on UniProtKB P77674.
ProteinModelPortalO69497.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000028888; EBMYCP00000028494; EBMYCG00000028883.
GeneID910883.
GenomeReviewsGene locus ML2573 in contig AL450380_GR.
KEGGmle:ML2573.
NMPDRfig|272631.1.peg.1520.
PATRIC18060063. VBIMycLep78757_4945.

Organism-specific databases

LepromaML2573.
CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000015659.
HOGENOMHBG752218.
OMAVPQSALY.
ProtClustDBPRK09406.

Enzyme and pathway databases

BioCycMLEP272631:ML2573-MONOMER.

Family and domain databases

InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00135.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGABD1_MYCLE
AccessionPrimary (citable) accession number: O69497
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: August 1, 1998
Last modified: January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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