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Protein

3-oxoacyl-[acyl-carrier-protein] synthase 2

Gene

kasB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.By similarity

Catalytic activityi

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathway: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei173 – 1731By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC:2.3.1.41)
Alternative name(s):
Beta-ketoacyl-ACP synthase 2
Short name:
KAS 2
Gene namesi
Name:kasB
Ordered Locus Names:ML1656
ORF Names:MLCB1243.19c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
ProteomesiUP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1656.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4204203-oxoacyl-[acyl-carrier-protein] synthase 2PRO_0000180332Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1656.

Structurei

3D structure databases

ProteinModelPortaliO69473.
SMRiO69473. Positions 7-420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.Curated

Phylogenomic databases

eggNOGiCOG0304.
HOGENOMiHOG000060166.
KOiK11609.
OrthoDBiEOG6DG2SR.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.

Sequencei

Sequence statusi: Complete.

O69473-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSPELVTG KAFPNVVVTG IAMTTALATD AETTWKLLLD NQSGIRMLDD
60 70 80 90 100
PFIEEFNLPV RIGGHLLEEF DHQLTRVELR RMGYLQRMST VLSRRLWENA
110 120 130 140 150
GSPEVDTNRL MVSIGTGLGS AEELVFSYDD MRARGMKAVS PLAVQKYMPN
160 170 180 190 200
GAAAAVGLEH HAKAGVMTPV SACASGSEAI AHAWQQIVLG EADSAICGGV
210 220 230 240 250
ETKIEAVPIA GFSQMRIVMS TKNDNPAGAC RPFDRDRDGF VFGEAGALML
260 270 280 290 300
IETEDSAKAR SANILARIMG ASITSDGFHM VAPDPNGERA GHAIARAVHL
310 320 330 340 350
AGLSPSDIDH VNAHATGTQV GDLAEAKAIN KALCNNRPAV YAPKSALGHS
360 370 380 390 400
VGAVGAVESI LTVLALRDQV IPPTLNLVNL DPDIDLDVVA GKPRPGDYRY
410 420
AVNNSFGFGG HNVAIAFGCY
Length:420
Mass (Da):44,497
Last modified:August 14, 2001 - v2
Checksum:iC015CF9CC5DC7E72
GO

Sequence cautioni

The sequence CAA19200.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAC30607.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL023635 Genomic DNA. Translation: CAA19200.1. Different initiation.
AL583922 Genomic DNA. Translation: CAC30607.1. Different initiation.
PIRiT44710.
RefSeqiWP_010908458.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30607; CAC30607; CAC30607.
KEGGimle:ML1656.
PATRICi18056384. VBIMycLep78757_3123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL023635 Genomic DNA. Translation: CAA19200.1. Different initiation.
AL583922 Genomic DNA. Translation: CAC30607.1. Different initiation.
PIRiT44710.
RefSeqiWP_010908458.1. NC_002677.1.

3D structure databases

ProteinModelPortaliO69473.
SMRiO69473. Positions 7-420.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1656.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30607; CAC30607; CAC30607.
KEGGimle:ML1656.
PATRICi18056384. VBIMycLep78757_3123.

Organism-specific databases

LepromaiML1656.

Phylogenomic databases

eggNOGiCOG0304.
HOGENOMiHOG000060166.
KOiK11609.
OrthoDBiEOG6DG2SR.

Enzyme and pathway databases

UniPathwayiUPA00094.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiFAB2_MYCLE
AccessioniPrimary (citable) accession number: O69473
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: June 24, 2015
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.