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O69473

- FAB2_MYCLE

UniProt

O69473 - FAB2_MYCLE

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Protein
3-oxoacyl-[acyl-carrier-protein] synthase 2
Gene
kasB, ML1656, MLCB1243.19c
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP By similarity.

Catalytic activityi

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei173 – 1731 By similarity

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC:2.3.1.41)
Alternative name(s):
Beta-ketoacyl-ACP synthase 2
Short name:
KAS 2
Gene namesi
Name:kasB
Ordered Locus Names:ML1656
ORF Names:MLCB1243.19c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML1656.

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4204203-oxoacyl-[acyl-carrier-protein] synthase 2
PRO_0000180332Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1656.

Structurei

3D structure databases

ProteinModelPortaliO69473.
SMRiO69473. Positions 7-420.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0304.
HOGENOMiHOG000060166.
KOiK11609.
OrthoDBiEOG6DG2SR.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 2 hits.

Sequencei

Sequence statusi: Complete.

O69473-1 [UniParc]FASTAAdd to Basket

« Hide

MTTSPELVTG KAFPNVVVTG IAMTTALATD AETTWKLLLD NQSGIRMLDD    50
PFIEEFNLPV RIGGHLLEEF DHQLTRVELR RMGYLQRMST VLSRRLWENA 100
GSPEVDTNRL MVSIGTGLGS AEELVFSYDD MRARGMKAVS PLAVQKYMPN 150
GAAAAVGLEH HAKAGVMTPV SACASGSEAI AHAWQQIVLG EADSAICGGV 200
ETKIEAVPIA GFSQMRIVMS TKNDNPAGAC RPFDRDRDGF VFGEAGALML 250
IETEDSAKAR SANILARIMG ASITSDGFHM VAPDPNGERA GHAIARAVHL 300
AGLSPSDIDH VNAHATGTQV GDLAEAKAIN KALCNNRPAV YAPKSALGHS 350
VGAVGAVESI LTVLALRDQV IPPTLNLVNL DPDIDLDVVA GKPRPGDYRY 400
AVNNSFGFGG HNVAIAFGCY 420
Length:420
Mass (Da):44,497
Last modified:August 14, 2001 - v2
Checksum:iC015CF9CC5DC7E72
GO

Sequence cautioni

The sequence CAA19200.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAC30607.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL023635 Genomic DNA. Translation: CAA19200.1. Different initiation.
AL583922 Genomic DNA. Translation: CAC30607.1. Different initiation.
PIRiT44710.
RefSeqiNP_302137.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30607; CAC30607; CAC30607.
GeneIDi910002.
KEGGimle:ML1656.
PATRICi18056384. VBIMycLep78757_3123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL023635 Genomic DNA. Translation: CAA19200.1 . Different initiation.
AL583922 Genomic DNA. Translation: CAC30607.1 . Different initiation.
PIRi T44710.
RefSeqi NP_302137.1. NC_002677.1.

3D structure databases

ProteinModelPortali O69473.
SMRi O69473. Positions 7-420.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272631.ML1656.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC30607 ; CAC30607 ; CAC30607 .
GeneIDi 910002.
KEGGi mle:ML1656.
PATRICi 18056384. VBIMycLep78757_3123.

Organism-specific databases

Lepromai ML1656.

Phylogenomic databases

eggNOGi COG0304.
HOGENOMi HOG000060166.
KOi K11609.
OrthoDBi EOG6DG2SR.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53901. SSF53901. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiFAB2_MYCLE
AccessioniPrimary (citable) accession number: O69473
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: May 14, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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