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O69473

- FAB2_MYCLE

UniProt

O69473 - FAB2_MYCLE

Protein

3-oxoacyl-[acyl-carrier-protein] synthase 2

Gene

kasB

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (14 Aug 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.By similarity

    Catalytic activityi

    Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei173 – 1731By similarity

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC:2.3.1.41)
    Alternative name(s):
    Beta-ketoacyl-ACP synthase 2
    Short name:
    KAS 2
    Gene namesi
    Name:kasB
    Ordered Locus Names:ML1656
    ORF Names:MLCB1243.19c
    OrganismiMycobacterium leprae (strain TN)
    Taxonomic identifieri272631 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000000806: Chromosome

    Organism-specific databases

    LepromaiML1656.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4204203-oxoacyl-[acyl-carrier-protein] synthase 2PRO_0000180332Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272631.ML1656.

    Structurei

    3D structure databases

    ProteinModelPortaliO69473.
    SMRiO69473. Positions 7-420.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-ketoacyl-ACP synthases family.Curated

    Phylogenomic databases

    eggNOGiCOG0304.
    HOGENOMiHOG000060166.
    KOiK11609.
    OrthoDBiEOG6DG2SR.

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53901. SSF53901. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    O69473-1 [UniParc]FASTAAdd to Basket

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    MTTSPELVTG KAFPNVVVTG IAMTTALATD AETTWKLLLD NQSGIRMLDD    50
    PFIEEFNLPV RIGGHLLEEF DHQLTRVELR RMGYLQRMST VLSRRLWENA 100
    GSPEVDTNRL MVSIGTGLGS AEELVFSYDD MRARGMKAVS PLAVQKYMPN 150
    GAAAAVGLEH HAKAGVMTPV SACASGSEAI AHAWQQIVLG EADSAICGGV 200
    ETKIEAVPIA GFSQMRIVMS TKNDNPAGAC RPFDRDRDGF VFGEAGALML 250
    IETEDSAKAR SANILARIMG ASITSDGFHM VAPDPNGERA GHAIARAVHL 300
    AGLSPSDIDH VNAHATGTQV GDLAEAKAIN KALCNNRPAV YAPKSALGHS 350
    VGAVGAVESI LTVLALRDQV IPPTLNLVNL DPDIDLDVVA GKPRPGDYRY 400
    AVNNSFGFGG HNVAIAFGCY 420
    Length:420
    Mass (Da):44,497
    Last modified:August 14, 2001 - v2
    Checksum:iC015CF9CC5DC7E72
    GO

    Sequence cautioni

    The sequence CAA19200.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAC30607.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL023635 Genomic DNA. Translation: CAA19200.1. Different initiation.
    AL583922 Genomic DNA. Translation: CAC30607.1. Different initiation.
    PIRiT44710.
    RefSeqiNP_302137.1. NC_002677.1.

    Genome annotation databases

    EnsemblBacteriaiCAC30607; CAC30607; CAC30607.
    GeneIDi910002.
    KEGGimle:ML1656.
    PATRICi18056384. VBIMycLep78757_3123.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL023635 Genomic DNA. Translation: CAA19200.1 . Different initiation.
    AL583922 Genomic DNA. Translation: CAC30607.1 . Different initiation.
    PIRi T44710.
    RefSeqi NP_302137.1. NC_002677.1.

    3D structure databases

    ProteinModelPortali O69473.
    SMRi O69473. Positions 7-420.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272631.ML1656.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC30607 ; CAC30607 ; CAC30607 .
    GeneIDi 910002.
    KEGGi mle:ML1656.
    PATRICi 18056384. VBIMycLep78757_3123.

    Organism-specific databases

    Lepromai ML1656.

    Phylogenomic databases

    eggNOGi COG0304.
    HOGENOMi HOG000060166.
    KOi K11609.
    OrthoDBi EOG6DG2SR.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53901. SSF53901. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TN.

    Entry informationi

    Entry nameiFAB2_MYCLE
    AccessioniPrimary (citable) accession number: O69473
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: August 14, 2001
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3