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Protein

Phosphopantetheine adenylyltransferase

Gene

coaD

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.UniRule annotation

Catalytic activityi

ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX), Pantothenate kinase (coaA)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (dfp)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (dfp)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9SubstrateUniRule annotation1
Binding sitei17ATPUniRule annotation1
Sitei17Transition state stabilizerUniRule annotation1
Binding sitei41SubstrateUniRule annotation1
Binding sitei73Substrate; via amide nitrogenUniRule annotation1
Binding sitei87SubstrateUniRule annotation1
Binding sitei98ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 10ATPUniRule annotation2
Nucleotide bindingi88 – 90ATPUniRule annotation3
Nucleotide bindingi122 – 128ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00241; UER00355

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphopantetheine adenylyltransferaseUniRule annotation (EC:2.7.7.3UniRule annotation)
Alternative name(s):
Dephospho-CoA pyrophosphorylaseUniRule annotation
Pantetheine-phosphate adenylyltransferaseUniRule annotation
Short name:
PPATUniRule annotation
Gene namesi
Name:coaDUniRule annotation
Synonyms:kdtB
Ordered Locus Names:ML1663
ORF Names:MLCB1243.10
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi

Organism-specific databases

LepromaiML1663

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001562371 – 160Phosphopantetheine adenylyltransferaseAdd BLAST160

Proteomic databases

PRIDEiO69466

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Protein-protein interaction databases

STRINGi272631.ML1663

Structurei

3D structure databases

ProteinModelPortaliO69466
SMRiO69466
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bacterial CoaD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZEF Bacteria
COG0669 LUCA
HOGENOMiHOG000006518
OrthoDBiPOG091H01F1

Family and domain databases

CDDicd02163 PPAT, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00151 PPAT_bact, 1 hit
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR001980 PPAT
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21342:SF1 PTHR21342:SF1, 1 hit
PfamiView protein in Pfam
PF01467 CTP_transf_like, 1 hit
PRINTSiPR01020 LPSBIOSNTHSS
TIGRFAMsiTIGR01510 coaD_prev_kdtB, 1 hit
TIGR00125 cyt_tran_rel, 1 hit

Sequencei

Sequence statusi: Complete.

O69466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVVCPGSF DPVTLGHIDV FERAAAQFDE VVVAILINPV KKGMFDLDER
60 70 80 90 100
IAMINESTMH LPNLRVEAGE GLVVALVRSR GMTAIVKGLR TGVDFEYELQ
110 120 130 140 150
MAQMNKHIAG VDTFFVATAP RYSFVSSSLV KEVAMLGGDV SELLPESVNR
160
RFREKMSGTS
Length:160
Mass (Da):17,496
Last modified:August 1, 1998 - v1
Checksum:i1F762492F3C0676C
GO

Sequence cautioni

The sequence CAC30616 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL023635 Genomic DNA Translation: CAA19191.1
AL583923 Genomic DNA Translation: CAC30616.1 Different initiation.
PIRiA87117
T44703
RefSeqiWP_010908464.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC30616; CAC30616; CAC30616

Entry informationi

Entry nameiCOAD_MYCLE
AccessioniPrimary (citable) accession number: O69466
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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