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Protein

Uncharacterized oxidoreductase ML1669

Gene

ML1669

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei57 – 571Proton donorBy similarity
Binding sitei115 – 1151SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi195 – 24753NADPBy similarityAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized oxidoreductase ML1669 (EC:1.-.-.-)
Gene namesi
Ordered Locus Names:ML1669
ORF Names:MLCB1243.03c
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1669.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Uncharacterized oxidoreductase ML1669PRO_0000380735Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1669.

Structurei

3D structure databases

ProteinModelPortaliO69462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiENOG4105CV8. Bacteria.
COG0656. LUCA.
HOGENOMiHOG000250272.
OMAiGTWQIPE.
OrthoDBiEOG68H8C2.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00062. ALDOKETO_REDUCTASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O69462-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPSTPRTSI PSITLNDENT MPLLGLGVAE LSEDETERAV LAALEIGCRL
60 70 80 90 100
IDTAAAYGNE AAVSRAIAAS GIPRAQLFVT TKLATPDQGF TKSQDACNAS
110 120 130 140 150
LDRLGMDYVD LYLIHWPAPP VGQYVDAWGG MIQSRGEGHA RSIGVCNFTE
160 170 180 190 200
EHLSAIIDLT FVTPAVNQIE LHPLLNQDEM RKSNAQHNVI TQSYTPLVLG
210 220 230 240 250
RLMDNSTLTA IAAEYGKTPA QVLLRWNLQL GNAVVFRSAK AEHIASNFDV
260 270 280
FDFELAVNHM DAMNELHDGT RLRPDPETYA GS
Length:282
Mass (Da):30,693
Last modified:August 1, 1998 - v1
Checksum:i54D63BBBBE4D120B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL023635 Genomic DNA. Translation: CAA19184.1.
AL583923 Genomic DNA. Translation: CAC30622.1.
PIRiT44699.
RefSeqiNP_302147.1. NC_002677.1.
WP_010908468.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30622; CAC30622; CAC30622.
GeneIDi910035.
KEGGimle:ML1669.
PATRICi18056448. VBIMycLep78757_3155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL023635 Genomic DNA. Translation: CAA19184.1.
AL583923 Genomic DNA. Translation: CAC30622.1.
PIRiT44699.
RefSeqiNP_302147.1. NC_002677.1.
WP_010908468.1. NC_002677.1.

3D structure databases

ProteinModelPortaliO69462.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1669.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30622; CAC30622; CAC30622.
GeneIDi910035.
KEGGimle:ML1669.
PATRICi18056448. VBIMycLep78757_3155.

Organism-specific databases

LepromaiML1669.

Phylogenomic databases

eggNOGiENOG4105CV8. Bacteria.
COG0656. LUCA.
HOGENOMiHOG000250272.
OMAiGTWQIPE.
OrthoDBiEOG68H8C2.

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00062. ALDOKETO_REDUCTASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiY1669_MYCLE
AccessioniPrimary (citable) accession number: O69462
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: August 1, 1998
Last modified: November 11, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.