Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60 kDa chaperonin

Gene

groL

Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-1192-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA
Ordered Locus Names:Cj1221
OrganismiCampylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
Taxonomic identifieri192222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000000799 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 54554560 kDa chaperoninPRO_0000063322Add
BLAST

Proteomic databases

PaxDbiO69289.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

IntActiO69289. 96 interactions.
MINTiMINT-6485241.
STRINGi192222.Cj1221.

Structurei

3D structure databases

ProteinModelPortaliO69289.
SMRiO69289. Positions 2-522.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
HOGENOMiHOG000076290.
KOiK04077.
OMAiKKQMDET.
OrthoDBiEOG6JDWBZ.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O69289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEIIFSDE ARNKLYEGVK KLNDAVKVTM GPRGRNVLIQ KSFGAPSITK
60 70 80 90 100
DGVSVAKEVE LKDSLENMGA SLVREVASKT ADQAGDGTTT ATVLAHAIFK
110 120 130 140 150
EGLRNITAGA NPIEVKRGMD KACEAIVAEL KKLSREVKDK KEIAQVATIS
160 170 180 190 200
ANSDEKIGNL IADAMEKVGK DGVITVEEAK SINDELNVVE GMQFDRGYLS
210 220 230 240 250
PYFITNAEKM TVELSSPYIL LFDKKITNLK DLLPVLEQIQ KTGKPLLIIA
260 270 280 290 300
EDIEGEALAT LVVNKLRGVL NISAVKAPGF GDRRKAMLED IAILTGGEVI
310 320 330 340 350
SEELGRTLES ATIQDLGQAS SVIIDKDNTT IVNGAGEKAN IDARVNQIKA
360 370 380 390 400
QIAETTSDYD REKLQERLAK LSGGVAVIKV GAATETEMKE KKDRVDDALS
410 420 430 440 450
ATKAAVEEGI VIGGGAALIK AKAKIKLDLQ GDEAIGAAIV ERALRAPLRQ
460 470 480 490 500
IAENAGFDAG VVVNSVENAK DENTGFDAAK GEYVNMLESG IIDPVKVERV
510 520 530 540
ALLNAVSVAS MLLTTEATIS EIKEDKPTMP DMSGMGGMGG MGGMM
Length:545
Mass (Da):57,971
Last modified:December 1, 2000 - v2
Checksum:i4DA80BC64330C41E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti179 – 1791A → P in CAA73778 (PubMed:10206714).Curated
Sequence conflicti383 – 3831A → T in CAA73778 (PubMed:10206714).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13334 Genomic DNA. Translation: CAA73778.1.
AF461064 Genomic DNA. Translation: AAL76936.1.
AF461534 Genomic DNA. Translation: AAL67841.1.
AF461535 Genomic DNA. Translation: AAL67842.1.
AF461537 Genomic DNA. Translation: AAL67844.1.
AL111168 Genomic DNA. Translation: CAL35336.1.
PIRiG81328.
RefSeqiWP_002858047.1. NC_002163.1.
YP_002344612.1. NC_002163.1.

Genome annotation databases

EnsemblBacteriaiCAL35336; CAL35336; Cj1221.
GeneIDi905511.
KEGGicje:Cj1221.
PATRICi20059400. VBICamJej33762_1203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13334 Genomic DNA. Translation: CAA73778.1.
AF461064 Genomic DNA. Translation: AAL76936.1.
AF461534 Genomic DNA. Translation: AAL67841.1.
AF461535 Genomic DNA. Translation: AAL67842.1.
AF461537 Genomic DNA. Translation: AAL67844.1.
AL111168 Genomic DNA. Translation: CAL35336.1.
PIRiG81328.
RefSeqiWP_002858047.1. NC_002163.1.
YP_002344612.1. NC_002163.1.

3D structure databases

ProteinModelPortaliO69289.
SMRiO69289. Positions 2-522.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO69289. 96 interactions.
MINTiMINT-6485241.
STRINGi192222.Cj1221.

Proteomic databases

PaxDbiO69289.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL35336; CAL35336; Cj1221.
GeneIDi905511.
KEGGicje:Cj1221.
PATRICi20059400. VBICamJej33762_1203.

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
HOGENOMiHOG000076290.
KOiK04077.
OMAiKKQMDET.
OrthoDBiEOG6JDWBZ.

Enzyme and pathway databases

BioCyciCJEJ192222:GJTS-1192-MONOMER.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, sequencing and molecular analysis of the Campylobacter jejuni groESL bicistronic operon."
    Thies F.L., Weishaupt A., Karch H., Hartung H.P., Giegerich G.
    Microbiology 145:89-98(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequencing of the cpn60 gene from various Campylobacter jejuni isolates."
    Cunningham A., Taboada E., Nash J.H., Wakarchuk W.W., Gilbert M.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 43429 / MK5-S7630 / Serotype O:1, ATCC 43432 / MK7 / Serotype O:4, ATCC 43438 / MK1 / Serotype O:10 and ATCC 43456 / MK290 / Serotype O:36.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700819 / NCTC 11168.

Entry informationi

Entry nameiCH60_CAMJE
AccessioniPrimary (citable) accession number: O69289
Secondary accession number(s): Q0P935, Q9PN75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: May 11, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.