ID   MQO_CORGL               Reviewed;         500 AA.
AC   O69282;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   16-JUN-2009, entry version 63.
DE   RecName: Full=Malate:quinone oxidoreductase;
DE            EC=1.1.99.16;
DE   AltName: Full=Malate dehydrogenase [acceptor];
DE   AltName: Full=MQO;
GN   Name=mqo; OrderedLocusNames=Cgl2001, cg2192;
OS   Corynebacterium glutamicum (Brevibacterium flavum).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Corynebacteriaceae; Corynebacterium.
OX   NCBI_TaxID=1718;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=R127;
RX   MEDLINE=98321634; PubMed=9660197;
RX   DOI=10.1046/j.1432-1327.1998.2540395.x;
RA   Molenaar D., van der Rest M.E., Petrovic S.;
RT   "Biochemical and genetic characterization of the membrane-associated
RT   malate dehydrogenase (acceptor) from Corynebacterium glutamicum.";
RL   Eur. J. Biochem. 254:395-403(1998).
RN   [2]
RP   SEQUENCE REVISION TO N-TERMINUS.
RA   van der Rest M.E.;
RL   Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025;
RA   Nakagawa S.;
RT   "Complete genomic sequence of Corynebacterium glutamicum ATCC 13032.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025;
RX   MEDLINE=22830012; PubMed=12948626; DOI=10.1016/S0168-1656(03)00154-8;
RA   Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M.,
RA   Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L.,
RA   Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B.,
RA   McHardy A.C., Meyer F., Moeckel B., Pfefferle W., Puehler A.,
RA   Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I.,
RA   Tauch A.;
RT   "The complete Corynebacterium glutamicum ATCC 13032 genome sequence
RT   and its impact on the production of L-aspartate-derived amino acids
RT   and vitamins.";
RL   J. Biotechnol. 104:5-25(2003).
RN   [5]
RP   PROTEIN SEQUENCE OF 2-6.
RC   STRAIN=R127;
RA   Molenaar D., van der Rest M.E., Petrovic S.;
RL   Submitted (AUG-1998) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: (S)-malate + acceptor = oxaloacetate + reduced
CC       acceptor.
CC   -!- COFACTOR: FAD. The FAD is tightly bound.
CC   -!- ENZYME REGULATION: Activated by lipids.
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein.
CC   -!- SIMILARITY: Belongs to the MQO family.
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DR   EMBL; AJ224946; CAA12237.1; -; Genomic_DNA.
DR   EMBL; BA000036; BAB99394.1; -; Genomic_DNA.
DR   EMBL; BX927153; CAF20342.1; -; Genomic_DNA.
DR   RefSeq; NP_601207.1; -.
DR   RefSeq; YP_226243.1; -.
DR   World-2DPAGE; 0001:O69282; -.
DR   PRIDE; O69282; -.
DR   GeneID; 1019958; -.
DR   GeneID; 3345228; -.
DR   GenomeReviews; BA000036_GR; Cgl2001.
DR   GenomeReviews; BX927147_GR; cg2192.
DR   KEGG; cgb:cg2192; -.
DR   KEGG; cgl:NCgl1926; -.
DR   HOGENOM; O69282; -.
DR   OMA; O69282; EGYAGFP.
DR   BioCyc; CGLU196627-1:CG2192-MON; -.
DR   BRENDA; 1.1.99.16; 812.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008924; F:malate dehydrogenase (acceptor) activity; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:HAMAP.
DR   HAMAP; MF_00212; -; 1.
DR   InterPro; IPR006231; Malate_quinone_OxRdtase.
DR   Pfam; PF06039; Mqo; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Complete proteome; Direct protein sequencing; FAD;
KW   Flavoprotein; Membrane; Oxidoreductase; Tricarboxylic acid cycle.
FT   INIT_MET      1      1       Removed.
FT   CHAIN         2    500       Malate:quinone oxidoreductase.
FT                                /FTId=PRO_0000128711.
SQ   SEQUENCE   500 AA;  54832 MW;  31E02BC151758319 CRC64;
     MSDSPKNAPR ITDEADVVLI GAGIMSSTLG AMLRQLEPSW TQIVFERLDG PAQESSSPWN
     NAGTGHSALC ELNYTPEVKG KVEIAKAVGI NEKFQVSRQF WSHLVEEGVL SDPKEFINPV
     PHVSFGQGAD QVAYIKARYE ALKDHPLFQG MTYADDEATF TEKLPLMAKG RDFSDPVAIS
     WIDEGTDINY GAQTKQYLDA AEVEGTEIRY GHEVKSIKAD GAKWIVTVKN VHTGDTKTIK
     ANFVFVGAGG YALDLLRSAG IPQVKGFAGF PVSGLWLRCT NEELIEQHAA KVYGKASVGA
     PPMSVPHLDT RVIEGEKGLL FGPYGGWTPK FLKEGSYLDL FKSIRPDNIP SYLGVAAQEF
     DLTKYLVTEV LKDQDKRMDA LREYMPEAQN GDWETIVAGQ RVQVIKPAGF PKFGSLEFGT
     TLINNSEGTI AGLLGASPGA SIAPSAMIEL LERCFGDRMI EWGDKLKDMI PSYGKKLASE
     PALFEQQWAR TQKTLKLEEA
//