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Protein

Malate:quinone oxidoreductase

Gene

mqo

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.

Cofactori

FADNote: The FAD is tightly bound.

Enzyme regulationi

Activated by lipids.

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).
Proteins known to be involved in this subpathway in this organism are:
  1. Malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciCORYNE:G18NG-11593-MONOMER
BRENDAi1.1.5.4 960
UniPathwayiUPA00223; UER01008

Names & Taxonomyi

Protein namesi
Recommended name:
Malate:quinone oxidoreductase (EC:1.1.5.4)
Alternative name(s):
MQO
Malate dehydrogenase [quinone]
Gene namesi
Name:mqo
Ordered Locus Names:Cgl2001, cg2192
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000582 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001287112 – 500Malate:quinone oxidoreductaseAdd BLAST499

2D gel databases

World-2DPAGEi0001:O69282

Interactioni

Protein-protein interaction databases

STRINGi196627.cg2192

Structurei

3D structure databases

ProteinModelPortaliO69282
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.Curated

Phylogenomic databases

eggNOGiENOG4105DWT Bacteria
COG0579 LUCA
HOGENOMiHOG000109379
KOiK00116
OMAiEPIAATK

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_00212 MQO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR006231 MQO
PfamiView protein in Pfam
PF06039 Mqo, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR01320 mal_quin_oxido, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O69282-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDSPKNAPR ITDEADVVLI GAGIMSSTLG AMLRQLEPSW TQIVFERLDG
60 70 80 90 100
PAQESSSPWN NAGTGHSALC ELNYTPEVKG KVEIAKAVGI NEKFQVSRQF
110 120 130 140 150
WSHLVEEGVL SDPKEFINPV PHVSFGQGAD QVAYIKARYE ALKDHPLFQG
160 170 180 190 200
MTYADDEATF TEKLPLMAKG RDFSDPVAIS WIDEGTDINY GAQTKQYLDA
210 220 230 240 250
AEVEGTEIRY GHEVKSIKAD GAKWIVTVKN VHTGDTKTIK ANFVFVGAGG
260 270 280 290 300
YALDLLRSAG IPQVKGFAGF PVSGLWLRCT NEELIEQHAA KVYGKASVGA
310 320 330 340 350
PPMSVPHLDT RVIEGEKGLL FGPYGGWTPK FLKEGSYLDL FKSIRPDNIP
360 370 380 390 400
SYLGVAAQEF DLTKYLVTEV LKDQDKRMDA LREYMPEAQN GDWETIVAGQ
410 420 430 440 450
RVQVIKPAGF PKFGSLEFGT TLINNSEGTI AGLLGASPGA SIAPSAMIEL
460 470 480 490 500
LERCFGDRMI EWGDKLKDMI PSYGKKLASE PALFEQQWAR TQKTLKLEEA
Length:500
Mass (Da):54,832
Last modified:January 23, 2007 - v3
Checksum:i31E02BC151758319
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224946 Genomic DNA Translation: CAA12237.1
BA000036 Genomic DNA Translation: BAB99394.1
BX927153 Genomic DNA Translation: CAF20342.1
RefSeqiNP_601207.1, NC_003450.3
WP_011014814.1, NC_006958.1

Genome annotation databases

EnsemblBacteriaiBAB99394; BAB99394; BAB99394
CAF20342; CAF20342; cg2192
GeneIDi1019958
KEGGicgb:cg2192
cgl:NCgl1926
PATRICifig|196627.13.peg.1940

Similar proteinsi

Entry informationi

Entry nameiMQO_CORGL
AccessioniPrimary (citable) accession number: O69282
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 124 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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