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Protein

Ribonucleoside-diphosphate reductase

Gene

nrdE

Organism
Corynebacterium ammoniagenes (Brevibacterium ammoniagenes)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.UniRule annotation

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

DNA replicationUniRule annotation

Enzyme and pathway databases

BRENDAi1.17.4.1. 959.
UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductaseUniRule annotation (EC:1.17.4.1UniRule annotation)
Gene namesi
Name:nrdEImported
OrganismiCorynebacterium ammoniagenes (Brevibacterium ammoniagenes)Imported
Taxonomic identifieri1697 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium

Interactioni

Protein-protein interaction databases

STRINGi649754.HMPREF0281_01189.

Structurei

3D structure databases

ProteinModelPortaliO69273.
SMRiO69273. Positions 17-705.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini572 – 59423RIBORED_LARGEInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ribonucleoside diphosphate reductase large chain family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZH. Bacteria.
COG0209. LUCA.

Family and domain databases

InterProiIPR013346. NrdE_NrdA.
IPR026459. RNR_1b_NrdE.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR013554. RNR_N.
IPR008926. RNR_R1-su_N.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
PF08343. RNR_N. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
SUPFAMiSSF48168. SSF48168. 1 hit.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
TIGR04170. RNR_1b_NrdE. 1 hit.
PROSITEiPS00089. RIBORED_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O69273-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQQLGKTVA EPVKNSEKLD FHALNALLNL YDEDGKIQFD KDREAANQYF
60 70 80 90 100
LQHVNQNTVY FHDLEEKIEY LVENKYYEPE VIEAYDWEFI KSLFKRAYSF
110 120 130 140 150
KFRFKSFLGA YKYYTSYTLK TFDGRRYLER FEDRVSMTAL FLADGDTAVA
160 170 180 190 200
ESMVDEIMSG RFQPATPTFL NAGKAQRGEL VSCFLLRIED NMESIGRAIN
210 220 230 240 250
SSLQLSKRGG GVALLLSNIR ESGAPIKHIE NQSSGIIPIM KMLEDAFSYA
260 270 280 290 300
NQLGARQGAG AVYLNAHHPD ILNFLDTKRE NADEKIRIKT LSLGIVIPDI
310 320 330 340 350
TFDLAKRNED MYLFSPYDVE RVYGKPFGDI SVSDHYAEMV EDPRITKKKI
360 370 380 390 400
NARHFFQTVA ELQFESGYPY IMFEDTVNNA NPVKTGRINM SNLCSEILQV
410 420 430 440 450
NSPSSFNDDL SYEEMGSDIS CNLGSMNIAL AMDSPDFGGT VEAAIRGLTA
460 470 480 490 500
VADKTAIDSV PSIRHGNDQS HAIGLGQMNL HGYLGREHIY YGSEEGLDFT
510 520 530 540 550
NAYFAAVLYA ALRASNKIAK ERGETFSEFK DSDYASGVFF DNYDPAEFAP
560 570 580 590 600
QTDKVKELFA NSTIHTPSAE DWADLKAEVM EHGLYNRNLQ AVPPTGSISY
610 620 630 640 650
INNSTSSIHP IASKIEIRKE GKIGRVYYPA PHMDNDNLDY FQDAYEVGHE
660 670 680 690 700
KIIDTYAVAT KYVDQGLSLT LFFRDTAATR DINRAQIFAW RKGIKTLYYI
710 720
RLRQMALAGT EIEGCVSCML
Length:720
Mass (Da):81,282
Last modified:August 1, 1998 - v1
Checksum:i5CCFF8DE988F25B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09572 Genomic DNA. Translation: CAA70765.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09572 Genomic DNA. Translation: CAA70765.1.

3D structure databases

ProteinModelPortaliO69273.
SMRiO69273. Positions 17-705.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi649754.HMPREF0281_01189.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105BZH. Bacteria.
COG0209. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00326.
BRENDAi1.17.4.1. 959.

Family and domain databases

InterProiIPR013346. NrdE_NrdA.
IPR026459. RNR_1b_NrdE.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR013554. RNR_N.
IPR008926. RNR_R1-su_N.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
PF08343. RNR_N. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
SUPFAMiSSF48168. SSF48168. 1 hit.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.
TIGR04170. RNR_1b_NrdE. 1 hit.
PROSITEiPS00089. RIBORED_LARGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The manganese-containing ribonucleotide reductase of Corynebacterium ammoniagenes is a class Ib enzyme."
    Fieschi F., Torrents E., Toulokhonova L., Jordan A., Hellman U., Barbe J., Gibert I., Karlsson M., Sjoeberg B.M.
    J. Biol. Chem. 273:4329-4337(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC6872Imported.

Entry informationi

Entry nameiO69273_CORAM
AccessioniPrimary (citable) accession number: O69273
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: July 6, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.