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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Lysinibacillus sphaericus (Bacillus sphaericus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Acts as a chaperone.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaK
Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene namesi
Name:dnaK
OrganismiLysinibacillus sphaericus (Bacillus sphaericus)
Taxonomic identifieri1421 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeLysinibacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 611610Chaperone protein DnaKPRO_0000078418Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei173 – 1731Phosphothreonine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

By stress conditions e.g. heat shock (By similarity).By similarity

Interactioni

Protein-protein interaction databases

STRINGi444177.Bsph_3798.

Structurei

3D structure databases

ProteinModelPortaliO69268.
SMRiO69268. Positions 1-505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O69268-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIIGIDLG TTNSCVSVLE GGEPKVIPNP EGNRTTPSVV AFKNGERQVG
60 70 80 90 100
EVAKRQSVTN PNTIISIKSK MGTAEKVTVE DKDYTPQEVS AMILQYLKGY
110 120 130 140 150
AEDYLGEKVT KAVITVPAYF NDAQRQATKD AGKIAGLEVE RIINEPTAAA
160 170 180 190 200
LRYGLDKQDQ DQKVLVFDLG GGTFDVSILE LGDGVFEVLA TAGDNKLGGD
210 220 230 240 250
DFDDAIIEYL VAEFKKENGI DLSKDKMAMQ RLKDAAEKAK KDLSGVTSTQ
260 270 280 290 300
ISLPFITAGE AGPLHLEISL TRAKFDEITL PLVNRTVGPV RQALSDAGLS
310 320 330 340 350
TSEIDQVILV GGSTRIPAVQ EAVRKETNKE PHRGVNPDEV VAMGAAVQGG
360 370 380 390 400
VLTGDVKDVV LLDVTPLSLG IETMGGVFTK LIDRNTTIPT SKSQVFSTAA
410 420 430 440 450
DNQPAVDIHV LQGERSMAAD NKTLGRFQLA DIPPAPRGVP QIEVTFDIDK
460 470 480 490 500
NGIVSVKAKD LGTNKEQTIV IQSDSGLSEA EIERMVKDAE ANRDADAKRK
510 520 530 540 550
EEADLRNEAD QLVFQVDKTI TDLGEQITED EKKSVEDARD ELKKALEAGE
560 570 580 590 600
LEGIKAAKEK LEGVLQPLVM KVYEQAAAAA QARQGGEADA GAGKKDDGVV
610
DADFEEVKDD K
Length:611
Mass (Da):65,558
Last modified:January 23, 2007 - v3
Checksum:i24FA34E461B8AE54
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17157 Genomic DNA. Translation: CAA76663.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17157 Genomic DNA. Translation: CAA76663.1.

3D structure databases

ProteinModelPortaliO69268.
SMRiO69268. Positions 1-505.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi444177.Bsph_3798.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CFG. Bacteria.
COG0443. LUCA.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Ahmad S., Selvapandiyan A., Gasbarri M., Bhatnagar R.K.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 33203 / 1593.

Entry informationi

Entry nameiDNAK_LYSSH
AccessioniPrimary (citable) accession number: O69268
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 23, 2007
Last modified: November 11, 2015
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.