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Protein

Chaperone protein HscA homolog

Gene

hscA

Organism
Azotobacter vinelandii
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein HscA homologUniRule annotation
Gene namesi
Name:hscAUniRule annotation
OrganismiAzotobacter vinelandii
Taxonomic identifieri354 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaeAzotobacter

Pathology & Biotechi

Disruption phenotypei

Essential, it cannot be deleted.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619Chaperone protein HscA homologPRO_0000078615Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi322710.Avin_40360.

Structurei

3D structure databases

ProteinModelPortaliO69221.
SMRiO69221. Positions 389-616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C9I. Bacteria.
COG0443. LUCA.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00679. HscA. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
IPR010236. ISC_FeS_clus_asmbl_HscA.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR01991. HscA. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O69221-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLQIAEPG QSPQPHQRRL AVGIDLGTTN SLVATLRSGL AESLKTPRGN
60 70 80 90 100
DPASAVRYLP DGRRVGRAAK AAAAVDPLNT VLSVKRLMGR GIADVKLLGE
110 120 130 140 150
QLPYRFAEGE SHMPFIETVQ GPKSPVEVSA EILRVLRRRA EEALGGELVG
160 170 180 190 200
AVITVPAYFD EAQRQATKDA ARLAGLDVLR LLNEPTAAAV AYGLDRGAEG
210 220 230 240 250
VVAIYDLGGG TFDISILRLT RGVFEVLATG GDSALGGDDF DHAIANWIVE
260 270 280 290 300
QAGLSADLDP GVQRHLLQLA CAAKEALSDS GSVTLAYGPW QGELSRERFE
310 320 330 340 350
ALIEPLVARS LKACRRALRD AGIEPQEIAA VVMVGGSTRV PRVRRAAAEL
360 370 380 390 400
FDRQPLTDID PDQVVAIGAA LQADTLAGNG RDGEELLLLD VNPLSLGLET
410 420 430 440 450
MGRLMEKVIP RNTTLPVARA QEFTTYKDGQ TAMLIHVLQG ERELVKDCRS
460 470 480 490 500
LARFELRGIP PMVAGAAKIR VTFQVDADGL LNVSARELGS GYEASVQVKP
510 520 530 540 550
SYGLTDGEIA RMLKDSFEYA GGDKAARALR EQQVEAQRLL EAVQAALEAD
560 570 580 590 600
GEALLSPAER AAIEAQMQAL RGVLDGPDAA VIETHVRHLT QVTDAFAARR
610
LDASVKAALS GRRLNEIEE
Length:619
Mass (Da):66,108
Last modified:August 1, 1998 - v1
Checksum:i2ACFEEFE68837D4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010139 Genomic DNA. Translation: AAC24478.1.
PIRiT44285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010139 Genomic DNA. Translation: AAC24478.1.
PIRiT44285.

3D structure databases

ProteinModelPortaliO69221.
SMRiO69221. Positions 389-616.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi322710.Avin_40360.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105C9I. Bacteria.
COG0443. LUCA.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00679. HscA. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
IPR010236. ISC_FeS_clus_asmbl_HscA.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR01991. HscA. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSCA_AZOVI
AccessioniPrimary (citable) accession number: O69221
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: August 1, 1998
Last modified: November 11, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.