O69211 (O69211_ACTPA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
3-dehydroquinate synthase HAMAP MF_00110
EC=4.2.3.4 HAMAP MF_00110

Gene names

Name:

aroB HAMAP MF_00110

Organism

Actinosynnema pretiosum subsp. auranticum EMBL AAC14006.1

Taxonomic identifier

42198 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Actinosynnemataceae › Actinosynnema

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. HAMAP MF_00110 NAD By similarity. HAMAP MF_00110
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity. HAMAP MF_00110
Subcellular location	Cytoplasm By similarity HAMAP MF_00110.
Sequence similarities	Belongs to the dehydroquinate synthase family. HAMAP MF_00110

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00110
Cellular component	Cytoplasm HAMAP MF_00110
Ligand	NAD HAMAP MF_00110
Molecular function	Lyase HAMAP MF_00110
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O69211 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: C98D335FFDD33F51	FASTA	342	35,746
	10 20 30 40 50 60 MPTTATTREV RVELGERAYT VHIGHGVRAA LPDVVRALGA RRAVVVTARP PDQTPDPGVP 70 80 90 100 110 120 SLVLPARDGE HDKTLATVAH LCSRFAEFGL TRADVVVSCG GGTTTDAVGL AASLYHRGTP 130 140 150 160 170 180 VVHVPTSLLA QVDASVGGKT AVNLPEGKNL VGSYWQPAAV LCDLDLLATL PERELRNGLG 190 200 210 220 230 240 EIARCHFIGA PGLDRLPLLD QVAASVALKA RVVAADERDR GLRHTLNYGH TLGHALELAT 250 260 270 280 290 300 GFAVRHGEGV AIGTVFAGRL AGALGRIGPD RVAEHHAVVA GYGLPVALPP GVPDDELLRF 310 320 330 340 VRRDKKSTGG LAFVLDGPRG AELVRDVDEH VVAATLAAMP RA

References

[1]	"Formation of 3-amino-5-hydroxy-benzoic acid, the precursor of mC7N units in ansamycin antibiotics, by a new variant of the shikimate pathway." Kim C.G., Kirschning A., Bergon P., Ahn Y., Wang J.J., Shibuya M., Floss H.G. J. Am. Chem. Soc. 114:4941-4943(1992) Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC31565 EMBL AAC14006.1.
[2]	"Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699." August P.R., Tang L., Yoon Y.J., Ning S., Muller R., Yu T.W., Taylor M., Hoffmann D., Kim C.G., Zhang X., Hutchinson C.R., Floss H.G. Chem. Biol. 5:69-79(1998) [PubMed: 9512878] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC31565 EMBL AAC14006.1.
[3]	"3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics." Kim C.G., Yu T.W., Fryhle C.B., Handa S., Floss H.G. J. Biol. Chem. 273:6030-6040(1998) [PubMed: 9497318] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC31565 EMBL AAC14006.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U33059 Genomic DNA. Translation: AAC14006.1.
3D structure databases
HSSP	HSSP built from PDB template 1DQS based on UniProtKB P07547.
ProteinModelPortal	O69211.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_00110. DHQ_synthase. [Tree]
InterPro	IPR016037. DHQ_synth_AroB. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

O69211_ACTPA

Accession

Primary (citable) accession number: O69211

Entry history

Integrated into UniProtKB/TrEMBL:	August 1, 1998
Last sequence update:	August 1, 1998
Last modified:	September 21, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)