ID   AK_PSEAE                Reviewed;         412 AA.
AC   O69077; Q9I552;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2001, sequence version 2.
DT   16-JUN-2009, entry version 57.
DE   RecName: Full=Aspartokinase;
DE            EC=2.7.2.4;
DE   AltName: Full=Aspartate kinase;
GN   Name=lysC; OrderedLocusNames=PA0904;
OS   Pseudomonas aeruginosa.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
RX   MEDLINE=20437337; PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T.,
RA   Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an
RT   opportunistic pathogen.";
RL   Nature 406:959-964(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 198-412.
RC   STRAIN=ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228;
RA   Hindle Z., Throup J.P., Francis K.P., Bycroft B.W., Williams P.,
RA   Stewart G.S.A.B.;
RL   Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + L-aspartate = ADP + 4-phospho-L-
CC       aspartate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; tetrahydrodipicolinate from L-aspartate: step 1/4.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 1/3.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 1/5.
CC   -!- SIMILARITY: Belongs to the aspartokinase family.
CC   -!- SIMILARITY: Contains 2 ACT domains.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AE004091; AAG04293.1; -; Genomic_DNA.
DR   EMBL; AF061757; AAC16241.1; -; Genomic_DNA.
DR   PIR; C83531; C83531.
DR   RefSeq; NP_249595.1; -.
DR   GeneID; 878315; -.
DR   GenomeReviews; AE004091_GR; PA0904.
DR   KEGG; pae:PA0904; -.
DR   PseudoCAP; PA0904; -.
DR   HOGENOM; O69077; -.
DR   OMA; O69077; YEEMLEM.
DR   BioCyc; PAER208964:PA0904-MON; -.
DR   BRENDA; 2.7.2.4; 354.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004072; F:aspartate kinase activity; IEA:EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0019877; P:diaminopimelate biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002912; ACT_bd.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR005260; Asp_kin_monofn.
DR   InterPro; IPR001341; Asp_kin_reg.
DR   InterPro; IPR018042; Aspartate_kinase_CS.
DR   Gene3D; G3DSA:3.40.1160.10; Aa_kinase; 1.
DR   Pfam; PF00696; AA_kinase; 1.
DR   Pfam; PF01842; ACT; 2.
DR   TIGRFAMs; TIGR00656; asp_kin_monofn; 1.
DR   TIGRFAMs; TIGR00657; asp_kinases; 1.
DR   PROSITE; PS00324; ASPARTOKINASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; ATP-binding; Complete proteome;
KW   Diaminopimelate biosynthesis; Kinase; Lysine biosynthesis;
KW   Nucleotide-binding; Repeat; Transferase.
FT   CHAIN         1    412       Aspartokinase.
FT                                /FTId=PRO_0000066679.
FT   DOMAIN      265    336       ACT 1.
FT   DOMAIN      345    410       ACT 2.
SQ   SEQUENCE   412 AA;  44389 MW;  A06ACAA5E914F337 CRC64;
     MALIVQKFGG TSVGTVERIE QVAEKVKKFR EAGDDVVVVV SAMSGETNRL IGLANQIMEQ
     PVPRELDVMV STGEQVTIAL LSMALIKRGV PAVSYTGNQV RILTDSAHTK ARILHIDDTH
     IRADLKAGRV VVVAGFQGVD GNGNITTLGR GGSDTTGVAL AAALKADECQ IYTDVDGVYT
     TDPRVVPQAR RLDKITFEEM LEMASLGSKV LQIRAVEFAG KYNVPLRVLH SFQEGPGTLI
     TIDDEEESME QPIISGIAFN RDEAKLTIRG VPDTPGVAFK ILGPISAANV EVDMIVQNVA
     HDNTTDFTFT VHRNDYLNAL EILKQTAANI GAREAIGDTN IAKVSIVGVG MRSHAGVASR
     MFEALAKESI NIQMISTSEI KVSVVIEEKY LELAVRALHT AFELDAPARQ GE
//