ID   MI2D_RHIME              Reviewed;         330 AA.
AC   O68965;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2001, sequence version 2.
DT   16-JUN-2009, entry version 57.
DE   RecName: Full=Inositol 2-dehydrogenase;
DE            EC=1.1.1.18;
DE   AltName: Full=Myo-inositol 2-dehydrogenase;
DE            Short=MI-dehydrogenase;
GN   Name=idhA; Synonyms=iolG; OrderedLocusNames=RB1194; ORFNames=SMb20899;
OS   Rhizobium meliloti (Sinorhizobium meliloti).
OG   Plasmid pSymB (megaplasmid 2).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=382;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION, AND FUNCTION AS
RP   MI-DEHYDROGENASE.
RC   STRAIN=1021;
RX   MEDLINE=99018841; PubMed=9802033;
RA   Galbraith M.P., Feng S.F., Borneman J., Triplett E.W., de Bruijn F.J.,
RA   Rossbach S.;
RT   "A functional myo-inositol catabolism pathway is essential for
RT   rhizopine utilization by Sinorhizobium meliloti.";
RL   Microbiology 144:2915-2924(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   MEDLINE=21396508; PubMed=11481431; DOI=10.1073/pnas.161294698;
RA   Finan T.M., Weidner S., Wong K., Buhrmester J., Chain P.,
RA   Vorhoelter F.J., Hernandez-Lucas I., Becker A., Cowie A., Gouzy J.,
RA   Golding B., Puehler A.;
RT   "The complete sequence of the 1,683-kb pSymB megaplasmid from the N2-
RT   fixing endosymbiont Sinorhizobium meliloti.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9889-9894(2001).
CC   -!- FUNCTION: Involved in the oxidation of myo-inositol (MI) to 2-
CC       keto-myo-inositol (2KMI or 2-inosose).
CC   -!- CATALYTIC ACTIVITY: Myo-inositol + NAD(+) = 2,4,6/3,5-
CC       pentahydroxycyclohexanone + NADH.
CC   -!- PATHWAY: Polyol metabolism; myo-inositol degradation into acetyl-
CC       CoA; acetyl-CoA from myo-inositol: step 1/7.
CC   -!- INDUCTION: By myo-inositol.
CC   -!- SIMILARITY: Belongs to the gfo/idh/mocA family.
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DR   EMBL; AF059313; AAC70005.1; -; Genomic_DNA.
DR   EMBL; AL591985; CAC49594.1; -; Genomic_DNA.
DR   PIR; B95991; B95991.
DR   RefSeq; NP_437734.1; -.
DR   GeneID; 1237525; -.
DR   GenomeReviews; AL591985_GR; RB1194.
DR   KEGG; sme:SM_b20899; -.
DR   NMPDR; fig|266834.1.peg.5829; -.
DR   HOGENOM; O68965; -.
DR   OMA; O68965; LERYMQS.
DR   BioCyc; SMEL266834:SMB20899-MON; -.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0050112; F:inositol 2-dehydrogenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR000683; Oxidoreductase_N.
DR   InterPro; IPR004104; OxRdtase_C.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01408; GFO_IDH_MocA; 1.
DR   Pfam; PF02894; GFO_IDH_MocA_C; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; NAD; Oxidoreductase; Plasmid.
FT   CHAIN         1    330       Inositol 2-dehydrogenase.
FT                                /FTId=PRO_0000091775.
FT   CONFLICT    226    226       S -> A (in Ref. 1; AAC70005).
SQ   SEQUENCE   330 AA;  35147 MW;  06F5FBBAC7484A58 CRC64;
     MTVRFGLLGA GRIGKVHAKA VSGNADARLV AVADAFPAAA EAIAGAYGCE VRTIDAIEAA
     ADIDAVVICT PTDTHADLIE RFARAGKAIF CEKPIDLDAE RVRACLKVVS DTKAKLMVGF
     NRRFDPHFMA VRKAIDDGRI GEVEMVTITS RDPSAPPVDY IKRSGGIFRD MTIHDFDMAR
     FLLGEEPVSV TATAAVLIDK AIGDAGDYDS VSVILQTASG KQAIISNSRR ATYGYDQRIE
     VHGSKGAVAA ENQRPVSIEI ATGDGYTRPP LHDFFMTRYT EAYANEIESF IAAIEKGAEI
     APSGNDGLAA LALADAAVRS VAEKRQISIA
//