O68926 (BFR_SALTY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Bacterioferritin
Short name=BFR
EC=1.16.3.1

Alternative name(s):
Cytochrome b-1
Cytochrome b-557

Gene names

Name:	bfr
Ordered Locus Names:	STM3443

Organism

Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]

Taxonomic identifier

99287 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella typhimurium

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Iron-storage protein, whose ferroxidase center binds Fe2+ ions, oxidizes them by dioxygen to Fe3+, and participates in the subsequent Fe3+ oxide mineral core formation within the central cavity of the protein complex By similarity.
Catalytic activity	4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per dimer By similarity. Binds 2 iron ions per subunit. The catalytic dinuclear iron-binding site within each subunit is known as the ferroxidase center By similarity.
Subunit structure	Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited By similarity.
Sequence similarities	Belongs to the bacterioferritin family. Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
Biological process	Iron storage
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW iron ion transport Inferred from electronic annotation. Source: InterPro
Molecular_function	ferric iron binding Inferred from electronic annotation. Source: InterPro ferroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 158	158	Bacterioferritin		PRO_0000192594
Regions
	Domain	1 – 145	145	Ferritin-like diiron
Sites
	Metal binding	18	1	Iron 1 By similarity
	Metal binding	51	1	Iron 1 By similarity
	Metal binding	51	1	Iron 2 By similarity
	Metal binding	52	1	Iron (heme axial ligand); shared with dimeric partner By similarity
	Metal binding	54	1	Iron 1 By similarity
	Metal binding	94	1	Iron 2 By similarity
	Metal binding	127	1	Iron 1 By similarity
	Metal binding	127	1	Iron 2 By similarity
	Metal binding	130	1	Iron 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	O68926 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 6D8145505FC59901	FASTA	158	18,355
	10 20 30 40 50 60 MKGDVKIINY LNKLLGNELV AINQYFLHAR MFKNWGLTRL NDVEYHESID EMKHADKYIE 70 80 90 100 110 120 RILFLEGIPN LQDLGKLGIG EDVEEMLRSD LRLELEGAKD LREAIAYADS VHDYVSRDMM 130 140 150 IEILADEEGH IDWLETELDL IAKLGMQNYL QSQIKVTD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Noorani S.M., Lindahl L., Zengel J.M. Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: LT2.
[2]	"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2." McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K. Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF058449 Genomic DNA. Translation: AAC14283.1. AE006468 Genomic DNA. Translation: AAL22306.1.
RefSeq	NP_462347.1. NC_003197.1.
3D structure databases
ProteinModelPortal	O68926.
SMR	O68926. Positions 1-155.
ModBase	Search...
Protein-protein interaction databases
STRING	99287.STM3443.
Proteomic databases
PaxDb	O68926.
PRIDE	O68926.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL22306; AAL22306; STM3443.
GeneID	1254966.
KEGG	stm:STM3443.
PATRIC	32385685. VBISalEnt20916_3640.
Phylogenomic databases
eggNOG	COG2193.
HOGENOM	HOG000262383.
KO	K03594.
OMA	HHIDFLE.
ProtClustDB	PRK10635.
Family and domain databases
Gene3D	1.20.1260.10. 1 hit.
InterPro	IPR002024. Bacterioferritin. IPR009040. Ferritin-like_diiron. IPR009078. Ferritin-like_SF. IPR012347. Ferritin-rel. IPR008331. Ferritin_DPS_dom. [Graphical view]
Pfam	PF00210. Ferritin. 1 hit. [Graphical view]
PIRSF	PIRSF002560. Bacterioferritin. 1 hit.
PRINTS	PR00601. BACFERRITIN.
SUPFAM	SSF47240. Ferritin/RR_like. 1 hit.
TIGRFAMs	TIGR00754. bfr. 1 hit.
PROSITE	PS00549. BACTERIOFERRITIN. 1 hit. PS50905. FERRITIN_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BFR_SALTY

Accession

Primary (citable) accession number: O68926

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program