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Protein

Superoxide dismutase [Cu-Zn] 2

Gene

sodC

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds 1 copper ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi67Copper; catalyticBy similarity1
Metal bindingi69Copper; catalyticBy similarity1
Metal bindingi92Copper; catalyticBy similarity1
Metal bindingi92Zinc; structuralBy similarity1
Metal bindingi101Zinc; structuralBy similarity1
Metal bindingi109Zinc; structuralBy similarity1
Metal bindingi112Zinc; structuralBy similarity1
Metal bindingi147Copper; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAntioxidant, Oxidoreductase
LigandCopper, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-1457-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] 2 (EC:1.15.1.1)
Alternative name(s):
SodCII
Gene namesi
Name:sodC
Synonyms:sodC2
Ordered Locus Names:STM1440
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000003282520 – 173Superoxide dismutase [Cu-Zn] 2Add BLAST154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi74 ↔ 169By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO68901
PRIDEiO68901

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi99287.STM1440

Structurei

3D structure databases

ProteinModelPortaliO68901
SMRiO68901
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108Z7T Bacteria
COG2032 LUCA
HOGENOMiHOG000263449
KOiK04565
OMAiHKGDIGN
PhylomeDBiO68901

Family and domain databases

CDDicd00305 Cu-Zn_Superoxide_Dismutase, 1 hit
Gene3Di2.60.40.200, 1 hit
InterProiView protein in InterPro
IPR036423 SOD-like_Cu/Zn_dom_sf
IPR024134 SOD_Cu/Zn_/chaperone
IPR018152 SOD_Cu/Zn_BS
IPR001424 SOD_Cu_Zn_dom
PANTHERiPTHR10003 PTHR10003, 1 hit
PfamiView protein in Pfam
PF00080 Sod_Cu, 1 hit
SUPFAMiSSF49329 SSF49329, 1 hit
PROSITEiView protein in PROSITE
PS00332 SOD_CU_ZN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O68901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRLSLAMVT LLACAGAQAA SEKVEMNLVT AQGVGQSIGT VVIDETEGGL
60 70 80 90 100
KFTPHLKALP PGEHGFHIHA NGSCQPAIKD GKAVAAEAAG GHLDPQNTGK
110 120 130 140 150
HEGPEGQGHL GDLPVLVVNN DGIASEPVTA PRLKSLDEVK DKALMIHVGG
160 170
DNMSDQPKPL GGGGMRYACG VIK
Length:173
Mass (Da):17,737
Last modified:August 1, 1998 - v1
Checksum:i5FDCF9F6EF64B3EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056931 Genomic DNA Translation: AAC13559.1
AE006468 Genomic DNA Translation: AAL20362.1
RefSeqiNP_460403.1, NC_003197.2
WP_000826819.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL20362; AAL20362; STM1440
GeneIDi1252958
KEGGistm:STM1440
PATRICifig|99287.12.peg.1523

Similar proteinsi

Entry informationi

Entry nameiSODC_SALTY
AccessioniPrimary (citable) accession number: O68901
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 1, 1998
Last modified: February 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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