Reviewed, UniProtKB/Swiss-Prot O68891 (PARC_ENTSA)

Names and origin

Protein names

Recommended name:
    DNA topoisomerase 4 subunit A
    EC=5.99.1.-
Alternative name(s):
    Topoisomerase IV subunit A

Gene names

Name:

parC

Organism

Enterobacter sakazakii

Taxonomic identifier

28141 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Cronobacter

Protein attributes

Sequence length	110 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Topoisomerase IV is essential for chromosome segregation. It has relaxation of supercoiled DNA activity. Performs the decatenation events required during the replication of a circular DNA molecule By similarity.
Subunit structure	Composed of two subunits: parC and parE.
Subcellular location	Cell membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the topoisomerase gyrA/parC subunit family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Ligand	DNA-binding
Molecular function	Isomerase Topoisomerase
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›110	›110	DNA topoisomerase 4 subunit A		PRO_0000145399
Experimental info
	Non-terminal residue	110	1

Sequences

	Sequence		Length	Mass (Da)
	O68891-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: EFD87D7ED5ECBA35	FASTA	110	12,314
	10 20 30 40 50 60 MYVIMDRALP FIGDGLKPVQ RRIVYAMSEL GLNASAKFKK SARTVGDVLG KYHPHGDSAC 70 80 90 100 110 YEAMVLMAQP FSYRYPLVDG QGNWGAPDDP KSFAAMRYTE SRLSKYSELL

References

[1]	Pirapatrungsuriya K., Amyes S.G.B., Thomson C.J. Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: NCTC 5920.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF056287 Genomic DNA. Translation: AAC13494.1.
3D structure databases
HSSP	HSSP built from PDB template 1AB4 based on UniProtKB P09097.
SMR	O68891. Positions 6-110.
ModBase	Search...
Family and domain databases
InterPro	IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. [Graphical view]
Gene3D	G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit.
Pfam	PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
ProDom	PD000742. DNA_topoisoIV. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
BindingDB	O68891.

Entry information

Entry name

PARC_ENTSA

Accession

Primary (citable) accession number: O68891

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	August 1, 1998
Last modified:	June 16, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)