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O68891 (PARC_ENTSA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 28, 2011. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA topoisomerase 4 subunit A

EC=5.99.1.-
Alternative name(s):
Topoisomerase IV subunit A
Gene names
Name:parC
OrganismEnterobacter sakazakii
Taxonomic identifier28141 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCronobacter

Protein attributes

Sequence length110 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule By similarity.

Subunit structure

Composed of two subunits: ParC and ParE By similarity.

Subcellular location

Cell membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   LigandDNA-binding
   Molecular functionIsomerase
Topoisomerase
Gene Ontology (GO)
   Biological processDNA topological change

Inferred from electronic annotation. Source: InterPro

   Cellular componentchromosome

Inferred from electronic annotation. Source: InterPro

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: InterPro

DNA topoisomerase (ATP-hydrolyzing) activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – ›110›110DNA topoisomerase 4 subunit A
PRO_0000145399

Experimental info

Non-terminal residue1101

Sequences

Sequence LengthMass (Da)Tools
O68891 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: EFD87D7ED5ECBA35

FASTA11012,314
        10         20         30         40         50         60 
MYVIMDRALP FIGDGLKPVQ RRIVYAMSEL GLNASAKFKK SARTVGDVLG KYHPHGDSAC 

        70         80         90        100        110 
YEAMVLMAQP FSYRYPLVDG QGNWGAPDDP KSFAAMRYTE SRLSKYSELL 

« Hide

References

[1]Pirapatrungsuriya K., Amyes S.G.B., Thomson C.J.
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: NCTC 5920.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF056287 Genomic DNA. Translation: AAC13494.1.

3D structure databases

ProteinModelPortalO68891.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_cen.
[Graphical view]
Gene3DG3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit.
PfamPF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
ProtoNetSearch...

Other

BindingDBO68891.

Entry information

Entry namePARC_ENTSA
AccessionPrimary (citable) accession number: O68891
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: June 28, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families