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Protein

Citrate synthase

Gene

gltA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Enzyme regulationi

Allosterically inhibited by NADH.By similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Citrate synthase (gltA)
  2. Aconitate hydratase B (acnB), 2-methylcitrate dehydratase (prpD), 2-methylcitrate synthase (prpC), Aconitate hydratase A (acnA)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei306PROSITE-ProRule annotation1
Active sitei363PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Transferase
Biological processTricarboxylic acid cycle

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-732-MONOMER
UniPathwayiUPA00223; UER00717

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:gltA
Ordered Locus Names:STM0730
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001699451 – 427Citrate synthaseAdd BLAST427

Proteomic databases

PaxDbiO68883
PRIDEiO68883

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi99287.STM0730

Structurei

3D structure databases

ProteinModelPortaliO68883
SMRiO68883
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Phylogenomic databases

eggNOGiENOG4105BZN Bacteria
COG0372 LUCA
HOGENOMiHOG000021224
KOiK01647
OMAiTVGWCAQ
PhylomeDBiO68883

Family and domain databases

Gene3Di1.10.230.101 hit
1.10.580.102 hits
InterProiView protein in InterPro
IPR016142 Citrate_synth-like_lrg_a-sub
IPR016143 Citrate_synth-like_sm_a-sub
IPR002020 Citrate_synthase
IPR019810 Citrate_synthase_AS
IPR024176 Citrate_synthase_bac-typ
IPR036969 Citrate_synthase_sf
IPR010953 Citrate_synthase_typ-I
PfamiView protein in Pfam
PF00285 Citrate_synt, 1 hit
PIRSFiPIRSF001369 Citrate_synth, 1 hit
PRINTSiPR00143 CITRTSNTHASE
SUPFAMiSSF48256 SSF48256, 1 hit
TIGRFAMsiTIGR01798 cit_synth_I, 1 hit
PROSITEiView protein in PROSITE
PS00480 CITRATE_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

O68883-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTKAKITL TGDTTIELDV LKGTLGQDVI DIRSLGSKGV FTFDPGFTST
60 70 80 90 100
ASCESKITFI DGDEGILLHR GFPIDQLATD SNYLEVCYIL LYGEKPTQEE
110 120 130 140 150
YDEFRTTVTR HTMIHEQITR LFHAFRRDSH PMAVMCGITG ALAAFYHDSL
160 170 180 190 200
DVNNPRHREI AAFRLLSKMP TMAAMCYKYS IGQPFVYPRN DLSYAGNFLN
210 220 230 240 250
MMFSTPCETY EVNPVLERAM DRILILHADH EQNASTSTVR TAGSSGANPF
260 270 280 290 300
ACIAAGIASL WGPAHGGANE AALKMLEEIS SVKHIPEFVR RAKDKNDSFR
310 320 330 340 350
LMGFGHRVYK NYDPRATVMR ETCHEVLKEL GTKDDLLEVA MELEHIALND
360 370 380 390 400
PYFIEKKLYP NVDFYSGIIL KAMGIPSSMF TVIFAMARTV GWIAHWNEMH
410 420
TDGMKIARPR QLYTGYDKRD FKSALKR
Length:427
Mass (Da):48,106
Last modified:August 1, 1998 - v1
Checksum:i2E708DBF21FAE1CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056043 Genomic DNA Translation: AAC12779.1
AE006468 Genomic DNA Translation: AAL19674.1
RefSeqiNP_459715.1, NC_003197.2
WP_000785817.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL19674; AAL19674; STM0730
GeneIDi1252250
KEGGistm:STM0730
PATRICifig|99287.12.peg.762

Similar proteinsi

Entry informationi

Entry nameiCISY_SALTY
AccessioniPrimary (citable) accession number: O68883
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: February 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome