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O68883 (CISY_SALTY) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase

EC=2.3.3.1
Gene names
Name:gltA
Ordered Locus Names:STM0730
OrganismSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [Reference proteome] [HAMAP]
Taxonomic identifier99287 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Enzyme regulation

Allosterically inhibited by NADH By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Subunit structure

Homohexamer By similarity.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Molecular functionTransferase
   Technical termAllosteric enzyme
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncitrate (Si)-synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 427427Citrate synthase
PRO_0000169945

Sites

Active site3061 By similarity
Active site3631 By similarity

Sequences

Sequence LengthMass (Da)Tools
O68883 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 2E708DBF21FAE1CB

FASTA42748,106
        10         20         30         40         50         60 
MADTKAKITL TGDTTIELDV LKGTLGQDVI DIRSLGSKGV FTFDPGFTST ASCESKITFI 

        70         80         90        100        110        120 
DGDEGILLHR GFPIDQLATD SNYLEVCYIL LYGEKPTQEE YDEFRTTVTR HTMIHEQITR 

       130        140        150        160        170        180 
LFHAFRRDSH PMAVMCGITG ALAAFYHDSL DVNNPRHREI AAFRLLSKMP TMAAMCYKYS 

       190        200        210        220        230        240 
IGQPFVYPRN DLSYAGNFLN MMFSTPCETY EVNPVLERAM DRILILHADH EQNASTSTVR 

       250        260        270        280        290        300 
TAGSSGANPF ACIAAGIASL WGPAHGGANE AALKMLEEIS SVKHIPEFVR RAKDKNDSFR 

       310        320        330        340        350        360 
LMGFGHRVYK NYDPRATVMR ETCHEVLKEL GTKDDLLEVA MELEHIALND PYFIEKKLYP 

       370        380        390        400        410        420 
NVDFYSGIIL KAMGIPSSMF TVIFAMARTV GWIAHWNEMH TDGMKIARPR QLYTGYDKRD 


FKSALKR 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequence of the citrate synthase gene of Salmonella typhimurium LT2."
Horswill A.R., Dudding A.R., Escalante-Semerena J.C.
Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: LT2.
[2]"Complete genome sequence of Salmonella enterica serovar Typhimurium LT2."
McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P., Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D., Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E. expand/collapse author list , Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R., Wilson R.K.
Nature 413:852-856(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: LT2 / SGSC1412 / ATCC 700720.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF056043 Genomic DNA. Translation: AAC12779.1.
AE006468 Genomic DNA. Translation: AAL19674.1.
RefSeqNP_459715.1. NC_003197.1.

3D structure databases

ProteinModelPortalO68883.
SMRO68883. Positions 2-427.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING99287.STM0730.

Proteomic databases

PaxDbO68883.
PRIDEO68883.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL19674; AAL19674; STM0730.
GeneID1252250.
KEGGstm:STM0730.
PATRIC32379819. VBISalEnt20916_0762.

Phylogenomic databases

eggNOGCOG0372.
HOGENOMHOG000021224.
KOK01647.
OMANKEDGVR.
OrthoDBEOG6P8TP4.
ProtClustDBPRK05614.

Enzyme and pathway databases

BioCycSENT99287:GCTI-734-MONOMER.
UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-II.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001369. Citrate_synth. 1 hit.
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01798. cit_synth_I. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_SALTY
AccessionPrimary (citable) accession number: O68883
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 13, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways