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Protein

Citrate synthase

Gene

gltA

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Enzyme regulationi

Allosterically inhibited by NADH.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei306 – 3061PROSITE-ProRule annotation
Active sitei363 – 3631PROSITE-ProRule annotation

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciSENT99287:GCTI-734-MONOMER.
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:gltA
Ordered Locus Names:STM0730
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Citrate synthasePRO_0000169945Add
BLAST

Proteomic databases

PaxDbiO68883.
PRIDEiO68883.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi99287.STM0730.

Structurei

3D structure databases

SMRiO68883. Positions 2-427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Phylogenomic databases

eggNOGiCOG0372.
HOGENOMiHOG000021224.
KOiK01647.
OMAiNKEDGVR.
OrthoDBiEOG6P8TP4.
PhylomeDBiO68883.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O68883-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTKAKITL TGDTTIELDV LKGTLGQDVI DIRSLGSKGV FTFDPGFTST
60 70 80 90 100
ASCESKITFI DGDEGILLHR GFPIDQLATD SNYLEVCYIL LYGEKPTQEE
110 120 130 140 150
YDEFRTTVTR HTMIHEQITR LFHAFRRDSH PMAVMCGITG ALAAFYHDSL
160 170 180 190 200
DVNNPRHREI AAFRLLSKMP TMAAMCYKYS IGQPFVYPRN DLSYAGNFLN
210 220 230 240 250
MMFSTPCETY EVNPVLERAM DRILILHADH EQNASTSTVR TAGSSGANPF
260 270 280 290 300
ACIAAGIASL WGPAHGGANE AALKMLEEIS SVKHIPEFVR RAKDKNDSFR
310 320 330 340 350
LMGFGHRVYK NYDPRATVMR ETCHEVLKEL GTKDDLLEVA MELEHIALND
360 370 380 390 400
PYFIEKKLYP NVDFYSGIIL KAMGIPSSMF TVIFAMARTV GWIAHWNEMH
410 420
TDGMKIARPR QLYTGYDKRD FKSALKR
Length:427
Mass (Da):48,106
Last modified:August 1, 1998 - v1
Checksum:i2E708DBF21FAE1CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056043 Genomic DNA. Translation: AAC12779.1.
AE006468 Genomic DNA. Translation: AAL19674.1.
RefSeqiNP_459715.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL19674; AAL19674; STM0730.
GeneIDi1252250.
KEGGistm:STM0730.
PATRICi32379819. VBISalEnt20916_0762.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF056043 Genomic DNA. Translation: AAC12779.1.
AE006468 Genomic DNA. Translation: AAL19674.1.
RefSeqiNP_459715.1. NC_003197.1.

3D structure databases

SMRiO68883. Positions 2-427.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM0730.

Proteomic databases

PaxDbiO68883.
PRIDEiO68883.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL19674; AAL19674; STM0730.
GeneIDi1252250.
KEGGistm:STM0730.
PATRICi32379819. VBISalEnt20916_0762.

Phylogenomic databases

eggNOGiCOG0372.
HOGENOMiHOG000021224.
KOiK01647.
OMAiNKEDGVR.
OrthoDBiEOG6P8TP4.
PhylomeDBiO68883.

Enzyme and pathway databases

UniPathwayiUPA00223; UER00717.
BioCyciSENT99287:GCTI-734-MONOMER.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of the citrate synthase gene of Salmonella typhimurium LT2."
    Horswill A.R., Dudding A.R., Escalante-Semerena J.C.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiCISY_SALTY
AccessioniPrimary (citable) accession number: O68883
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: April 1, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.