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Protein

Aquaporin Z

Gene

aqpZ

Organism
Shigella flexneri
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei20Involved in tetramerization or stability of the tetramer1
Sitei43Selectivity filterUniRule annotation1
Sitei174Selectivity filterUniRule annotation1
Sitei183Selectivity filterUniRule annotation1
Sitei189Selectivity filterUniRule annotation1

GO - Molecular functioni

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin ZUniRule annotation
Gene namesi
Name:aqpZUniRule annotation
Synonyms:bniP
Ordered Locus Names:SF0832, S0873
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalUniRule annotationAdd BLAST21
Topological domaini30 – 33PeriplasmicSequence analysis4
Transmembranei34 – 54HelicalUniRule annotationAdd BLAST21
Topological domaini55 – 81CytoplasmicSequence analysisAdd BLAST27
Transmembranei82 – 102HelicalUniRule annotationAdd BLAST21
Topological domaini103 – 130PeriplasmicSequence analysisAdd BLAST28
Transmembranei131 – 151HelicalUniRule annotationAdd BLAST21
Topological domaini152 – 155CytoplasmicSequence analysis4
Transmembranei156 – 176HelicalUniRule annotationAdd BLAST21
Topological domaini177 – 201PeriplasmicSequence analysisAdd BLAST25
Transmembranei202 – 222HelicalUniRule annotationAdd BLAST21
Topological domaini223 – 231CytoplasmicSequence analysis9

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

DrugBankiDB03152 B-2-Octylglucoside

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000640001 – 231Aquaporin ZAdd BLAST231

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO68874
SMRiO68874
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi63 – 65NPA 13
Motifi186 – 188NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D8C Bacteria
COG0580 LUCA
HOGENOMiHOG000288286
KOiK06188
OMAiELFGTFW

Family and domain databases

CDDicd00333 MIP, 1 hit
Gene3Di1.20.1080.10, 1 hit
HAMAPiMF_01146 Aquaporin_Z, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR034294 Aquaporin_transptr
IPR023743 Aquaporin_Z
IPR000425 MIP
IPR022357 MIP_CS
PANTHERiPTHR19139 PTHR19139, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PRINTSiPR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit
TIGRFAMsiTIGR00861 MIP, 1 hit
PROSITEiView protein in PROSITE
PS00221 MIP, 1 hit

Sequencei

Sequence statusi: Complete.

O68874-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRKLAAECF GTFWLVFGGC GSAVLAAGFP ELGIGFAGVA LAFGLTVLTM
60 70 80 90 100
AFAVGHISGG HFNPAVTIGL WAGGRFPAKE VVGYVIAQVV GGIVAAALLY
110 120 130 140 150
LIASGKTGFD AAASGFASNG YGEHSPGGYS MLSALVVELV LSAGFLLVIH
160 170 180 190 200
GATDKFAPAG FAPIAIGLAL TLIHLISIPV TNTSVNPARS TAVAIFQGGW
210 220 230
ALEQLWFFWV VPIVGGIIGG LIYRTLLEKR D
Length:231
Mass (Da):23,703
Last modified:April 13, 2004 - v2
Checksum:i3BDE1A932D45CF14
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43F → I in AAC12651 (Ref. 1) Curated1
Sequence conflicti99L → V in AAC12651 (Ref. 1) Curated1
Sequence conflicti176I → M in AAC12651 (Ref. 1) Curated1
Sequence conflicti227L → V in AAC12651 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055905 Genomic DNA Translation: AAC12651.1
AE005674 Genomic DNA Translation: AAN42465.2
AE014073 Genomic DNA Translation: AAP16338.1
RefSeqiNP_706758.2, NC_004337.2
WP_001298299.1, NZ_MTPK01000287.1

Genome annotation databases

EnsemblBacteriaiAAN42465; AAN42465; SF0832
AAP16338; AAP16338; S0873
GeneIDi1023778
KEGGisfl:SF0832
sfx:S0873
PATRICifig|198214.7.peg.961

Similar proteinsi

Entry informationi

Entry nameiAQPZ_SHIFL
AccessioniPrimary (citable) accession number: O68874
Secondary accession number(s): P48838, P75827, Q47159
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: April 25, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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