Reviewed, UniProtKB/Swiss-Prot O68873 (ARGE_MYXXA)

Names and origin

Protein names

Recommended name:
    Acetylornithine deacetylase
      Short name=Acetylornithinase
      Short name=AO
    EC=3.5.1.16
Alternative name(s):
    N-acetylornithinase
      Short name=NAO

Gene names

Name:

argE

Organism

Myxococcus xanthus

Taxonomic identifier

34 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Cystobacterineae › Myxococcaceae › Myxococcus

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	N(2)-acetyl-L-ornithine + H2O = acetate + L-ornithine. HAMAP MF_01108
Cofactor	Binds 2 zinc or cobalt ions per subunit By similarity. HAMAP MF_01108 Glutathione By similarity. HAMAP MF_01108
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine from N(2)-acetyl-L-ornithine (linear): step 1/1. HAMAP MF_01108
Subunit structure	Homodimer By similarity. HAMAP MF_01108
Subcellular location	Cytoplasm Probable HAMAP MF_01108.
Sequence similarities	Belongs to the peptidase M20A family. ArgE subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	Cobalt Metal-binding Zinc
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acetylornithine deacetylase activity Inferred from electronic annotation. Source: HAMAP cobalt ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 380	380	Acetylornithine deacetylase HAMAP MF_01108		PRO_0000185245
Sites
	Active site	81	1	By similarity
	Active site	139	1	Proton acceptor By similarity
	Metal binding	79	1	Cobalt or zinc 1 By similarity
	Metal binding	109	1	Cobalt or zinc 1 By similarity
	Metal binding	109	1	Cobalt or zinc 2 By similarity
	Metal binding	140	1	Cobalt or zinc 2 By similarity
	Metal binding	164	1	Cobalt or zinc 1 By similarity
	Metal binding	351	1	Cobalt or zinc 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	O68873-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 7233FEB6763CF71A	FASTA	380	40,715
	10 20 30 40 50 60 MSDTLPALRA TLTELVAMDT TSFRPNVPLI DYAQARLEAA GFSAERQKFL DDAGVEKVNL 70 80 90 100 110 120 VAVKGGSGSG RAALALVGHS DCVPYDAAWT DALRLTEKDG RLYARGACDT KGFIACALHA 130 140 150 160 170 180 ALNAEQLKAP LMVVLTADEE VGLTGAKKLV EAGLGRARHA IVGEPTRLIP VRANKGYCLA 190 200 210 220 230 240 EVEVRGKEGH SAYPDSGASA IFRAGRFLQR LEHLALTVLR EDLDEGFQPP FTTVNVGVIQ 250 260 270 280 290 300 GGKAKNVIPG ACRFVVEWRP IPGQPPERVS QLLETIRQEL VRDEPAFEAQ IRVVRTDRGV 310 320 330 340 350 360 NTRADAEVVR FLAEASGNAP ETVSFGTEAP QMTELGAEAV VFGPGDIRVA HQTGEYVPVE 370 380 DLVRCEAVLA RAVAHFCGGR

References

[1]	"Identification and characterization of the Myxococcus xanthus argE gene." Harris B.Z., Singer M. J. Bacteriol. 180:6412-6414(1998) [PubMed: 9829957] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION. Strain: DK101.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF055904 Genomic DNA. Translation: AAC82366.1.
3D structure databases
SMR	O68873. Positions 5-379.
ModBase	Search...
Protein family/group databases
MEROPS	M20.974.
Enzyme and pathway databases
BRENDA	3.5.1.16. 926.
Family and domain databases
HAMAP	MF_01108. ArgE. [Tree]
InterPro	IPR010169. AcOrn-deacetyl. IPR001261. ArgE/DapE_CS. IPR002933. Peptidase_M20. IPR011650. Peptidase_M20_dimer. [Graphical view]
Pfam	PF07687. M20_dimer. 1 hit. PF01546. Peptidase_M20. 1 hit. [Graphical view]
TIGRFAMs	TIGR01892. AcOrn-deacetyl. 1 hit.
PROSITE	PS00758. ARGE_DAPE_CPG2_1. False negative. PS00759. ARGE_DAPE_CPG2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGE_MYXXA

Accession

Primary (citable) accession number: O68873

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
Last sequence update:	August 1, 1998
Last modified:	February 9, 2010
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)