ID   NUOA1_RHIME             Reviewed;         121 AA.
AC   O68852;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   16-JUN-2009, entry version 59.
DE   RecName: Full=NADH-quinone oxidoreductase subunit A 1;
DE            EC=1.6.99.5;
DE   AltName: Full=NADH dehydrogenase I subunit A 1;
DE   AltName: Full=NDH-1 subunit A 1;
DE   AltName: Full=NUO1 1;
GN   Name=nuoA1; Synonyms=nuoA; OrderedLocusNames=R01264;
GN   ORFNames=SMc01912;
OS   Rhizobium meliloti (Sinorhizobium meliloti).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=382;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=RCR2011 / SU47;
RA   Schmidt R., Uhde C., Nagel A., Puehler A., Selbitschka W.;
RT   "Sinorhizobium meliloti mutant strain SP10 which is impaired in
RT   stationary phase survival shows a reduction in the energy charge due
RT   to its defect in the energy-conserving NADH dehydrogenase.";
RL   Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=41;
RA   Putnoky P., Jady B., Chellapilla K.P., Barta F., Kiss E.;
RT   "Rhizobium meliloti carries two sets of nuo genes.";
RL   Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   MEDLINE=21396507; PubMed=11481430; DOI=10.1073/pnas.161294398;
RA   Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA   Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA   Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D.,
RA   Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U.,
RA   Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT   "Analysis of the chromosome sequence of the legume symbiont
RT   Sinorhizobium meliloti strain 1021.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
CC   -!- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-
CC       sulfur (Fe-S) centers, to quinones in the respiratory chain. The
CC       immediate electron acceptor for the enzyme in this species is
CC       believed to be ubiquinone. Couples the redox reaction to proton
CC       translocation (for every two electrons transferred, four hydrogen
CC       ions are translocated across the cytoplasmic membrane), and thus
CC       conserves the redox energy in a proton gradient (By similarity).
CC   -!- CATALYTIC ACTIVITY: NADH + quinone = NAD(+) + quinol.
CC   -!- SUBUNIT: NDH-1 is composed of 14 different subunits. Subunits
CC       nuoA, H, J, K, L, M, N constitute the membrane sector of the
CC       complex (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC       protein (By similarity).
CC   -!- SIMILARITY: Belongs to the complex I subunit 3 family.
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DR   EMBL; AF055637; AAC12754.1; -; Genomic_DNA.
DR   EMBL; AJ245398; CAB51620.1; -; Genomic_DNA.
DR   EMBL; AL591688; CAC45843.1; -; Genomic_DNA.
DR   RefSeq; NP_385370.1; -.
DR   GeneID; 1232912; -.
DR   GenomeReviews; AL591688_GR; R01264.
DR   KEGG; sme:SMc01912; -.
DR   NMPDR; fig|266834.1.peg.2558; -.
DR   HOGENOM; O68852; -.
DR   OMA; O68852; IGFAYEW.
DR   BioCyc; SMEL266834:SMC01912-MON; -.
DR   BRENDA; 1.6.99.5; 142.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR   GO; GO:0048038; F:quinone binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:HAMAP.
DR   GO; GO:0019684; P:photosynthesis, light reaction; IEA:HAMAP.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   HAMAP; MF_01394; -; 1.
DR   InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR   PANTHER; PTHR11058; Oxidored_q4; 1.
DR   Pfam; PF00507; Oxidored_q4; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Complete proteome; Membrane; NAD;
KW   Oxidoreductase; Quinone; Transmembrane; Transport; Ubiquinone.
FT   CHAIN         1    121       NADH-quinone oxidoreductase subunit A 1.
FT                                /FTId=PRO_0000117872.
FT   TRANSMEM     11     31       Potential.
FT   TRANSMEM     65     85       Potential.
FT   TRANSMEM     90    110       Potential.
SQ   SEQUENCE   121 AA;  13804 MW;  D3E255E405310163 CRC64;
     MTELLGSYVP IAIFIGIALV IGLALLVAPF AVAFKAPDSE KLSAYECGFN AFDDARMKFD
     VRFYLVSILF IIFDLEVAFL FPWAVSFKEM GWFGFWSMMV FLLVLTVGFI YEWKKGALEW
     N
//