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O68839

- O68839_VIBCL

UniProt

O68839 - O68839_VIBCL

Protein

Type 4 prepilin-like proteins leader peptide-processing enzyme

Gene

pilD

Organism
Vibrio cholerae
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Aug 1998)
      Previous versions | rss
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    Functioni

    Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue.UniRule annotation
    Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue By similarity.

    Catalytic activityi

    Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine.UniRule annotation

    GO - Molecular functioni

    1. aspartic-type endopeptidase activity Source: InterPro
    2. methyltransferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. pathogenesis Source: TIGR
    2. protein secretion Source: TIGR

    Keywords - Molecular functioni

    Hydrolase, MethyltransferaseUniRule annotation, ProteaseUniRule annotation, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type 4 prepilin-like proteins leader peptide-processing enzymeUniRule annotation (EC:2.1.1.-UniRule annotation, EC:3.4.23.43UniRule annotation)
    Gene namesi
    Name:pilDImported
    OrganismiVibrio choleraeImported
    Taxonomic identifieri666 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

    Subcellular locationi

    Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Interactioni

    Protein-protein interaction databases

    STRINGi243277.VC2426.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase A24 family.UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Family and domain databases

    InterProiIPR010627. Pept_A24A_N.
    IPR014032. Peptidase_A24A_bac.
    IPR000045. Prepilin_IV_endopep_pep.
    [Graphical view]
    PfamiPF06750. DiS_P_DiS. 1 hit.
    PF01478. Peptidase_A24. 1 hit.
    [Graphical view]
    PRINTSiPR00864. PREPILNPTASE.

    Sequencei

    Sequence statusi: Complete.

    O68839-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELFYFYPWL FPVLATLFGL IVGSFLNVVI YRLPKIMERE WRAECAASFP    50
    EYGITPPEGK LTLSLPRSTC PHCQTPIRVI DNIPLLSWLA LRGQCSHCKA 100
    PISARYPLIE LLTALMSLVI ATHFPFGVFA VALLFFSYVL IAATFIDFDT 150
    LLLPDQLTLP LLWGGIALAL LGFSPVSLSD AVIGAMAGYL SLWSIYWLFK 200
    LLTGKEGMGY GDFKLLAALG AWLGWQQLPV IVLLSSVVGV IFGLIQLRQQ 250
    KKGIDMAFPF GPYLAIAGWF ALLWGDKVID WYFTTWVGQP L 291
    Length:291
    Mass (Da):32,434
    Last modified:August 1, 1998 - v1
    Checksum:i9A1ECD8D730A6EEF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF055371 Genomic DNA. Translation: AAC63504.1.
    AF109904 Genomic DNA. Translation: AAD21032.1.
    PIRiB82078.

    Genome annotation databases

    PATRICi20083869. VBIVibCho83274_2309.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF055371 Genomic DNA. Translation: AAC63504.1 .
    AF109904 Genomic DNA. Translation: AAD21032.1 .
    PIRi B82078.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VC2426.

    Protocols and materials databases

    DNASUi 2612968.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    PATRICi 20083869. VBIVibCho83274_2309.

    Family and domain databases

    InterProi IPR010627. Pept_A24A_N.
    IPR014032. Peptidase_A24A_bac.
    IPR000045. Prepilin_IV_endopep_pep.
    [Graphical view ]
    Pfami PF06750. DiS_P_DiS. 1 hit.
    PF01478. Peptidase_A24. 1 hit.
    [Graphical view ]
    PRINTSi PR00864. PREPILNPTASE.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the Vibrio cholerae type 4 prepilin peptidase required for cholera toxin secretion and pilus formation."
      Marsh J.W., Taylor R.K.
      Mol. Microbiol. 29:1481-1492(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C6706str2Imported.
    2. "Genetic characterization of a new type IV-A pilus gene cluster found in both classical and El Tor biotypes of Vibrio cholerae."
      Fullner K.J., Mekalanos J.J.
      Infect. Immun. 67:1393-1404(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiO68839_VIBCL
    AccessioniPrimary (citable) accession number: O68839
    Secondary accession number(s): Q7DCT3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 1, 1998
    Last sequence update: August 1, 1998
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Multifunctional enzymeUniRule annotation

    External Data

    Dasty 3