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Protein

Type 4 prepilin-like proteins leader peptide-processing enzyme

Gene

outO

Organism
Vibrio cholerae
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue.UniRule annotation

Catalytic activityi

Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • pathogenesis Source: TIGR
  • protein secretion Source: TIGR

Keywordsi

Molecular functionHydrolase, MethyltransferaseUniRule annotationImported, Multifunctional enzymeUniRule annotation, ProteaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Type 4 prepilin-like proteins leader peptide-processing enzymeUniRule annotation (EC:2.1.1.-UniRule annotation, EC:3.4.23.43UniRule annotation)
Gene namesi
Name:outOImported
Synonyms:pilDImported
ORF Names:BTY66_08275Imported, EN12_11765Imported, ERS013138_03101Imported, ERS013140_00632Imported, ERS013199_02129Imported, ERS013202_00444Imported, ERS013206_00688Imported, ERS013208_00947Imported
OrganismiVibrio choleraeImported
Taxonomic identifieri666 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000039011 Componenti: Unassembled WGS sequence
  • UP000043247 Componenti: Unassembled WGS sequence
  • UP000192124 Componenti: Unassembled WGS sequence
  • UP000040416 Componenti: Unassembled WGS sequence
  • UP000045183 Componenti: Unassembled WGS sequence
  • UP000045578 Componenti: Unassembled WGS sequence
  • UP000042589 Componenti: Unassembled WGS sequence
  • UP000036184 Componenti: Chromosome 1

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 30HelicalSequence analysisAdd BLAST25
Transmembranei112 – 145HelicalSequence analysisAdd BLAST34
Transmembranei157 – 174HelicalSequence analysisAdd BLAST18
Transmembranei181 – 199HelicalSequence analysisAdd BLAST19
Transmembranei219 – 245HelicalSequence analysisAdd BLAST27
Transmembranei257 – 275HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 124DiS_P_DiSInterPro annotationAdd BLAST108
Domaini135 – 244Peptidase_A24InterPro annotationAdd BLAST110

Sequence similaritiesi

Belongs to the peptidase A24 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG4105EHH Bacteria
COG1989 LUCA
KOiK02654

Family and domain databases

InterProiView protein in InterPro
IPR010627 Pept_A24A_N
IPR014032 Peptidase_A24A_bac
IPR000045 Prepilin_IV_endopep_pep
PfamiView protein in Pfam
PF06750 DiS_P_DiS, 1 hit
PF01478 Peptidase_A24, 1 hit
PRINTSiPR00864 PREPILNPTASE

Sequencei

Sequence statusi: Complete.

O68839-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELFYFYPWL FPVLATLFGL IVGSFLNVVI YRLPKIMERE WRAECAASFP
60 70 80 90 100
EYGITPPEGK LTLSLPRSTC PHCQTPIRVI DNIPLLSWLA LRGQCSHCKA
110 120 130 140 150
PISARYPLIE LLTALMSLVI ATHFPFGVFA VALLFFSYVL IAATFIDFDT
160 170 180 190 200
LLLPDQLTLP LLWGGIALAL LGFSPVSLSD AVIGAMAGYL SLWSIYWLFK
210 220 230 240 250
LLTGKEGMGY GDFKLLAALG AWLGWQQLPV IVLLSSVVGV IFGLIQLRQQ
260 270 280 290
KKGIDMAFPF GPYLAIAGWF ALLWGDKVID WYFTTWVGQP L
Length:291
Mass (Da):32,434
Last modified:August 1, 1998 - v1
Checksum:i9A1ECD8D730A6EEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055371 Genomic DNA Translation: AAC63504.1
AF109904 Genomic DNA Translation: AAD21032.1
CP007653 Genomic DNA Translation: AKO75893.1
CWQG01000001 Genomic DNA Translation: CSB54571.1
CWQD01000002 Genomic DNA Translation: CSB72863.1
CWRE01000011 Genomic DNA Translation: CSC51491.1
CWQX01000025 Genomic DNA Translation: CSC60610.1
CWRC01000094 Genomic DNA Translation: CSD35635.1
CWSS01000144 Genomic DNA Translation: CSI44827.1
MSEO01000006 Genomic DNA Translation: OQM90194.1
PIRiB82078
RefSeqiWP_000418747.1, NZ_PQCW01000031.1

Genome annotation databases

EnsemblBacteriaiAKO75893; AKO75893; EN12_11765
CSB54571; CSB54571; ERS013202_00444
CSB72863; CSB72863; ERS013206_00688
CSC51491; CSC51491; ERS013140_00632
CSC60610; CSC60610; ERS013199_02129
CSD35635; CSD35635; ERS013138_03101
CSI44827; CSI44827; ERS013208_00947
KEGGivcq:EN18_15165
PATRICifig|666.1968.peg.2720

Similar proteinsi

Entry informationi

Entry nameiO68839_VIBCL
AccessioniPrimary (citable) accession number: O68839
Secondary accession number(s): Q7DCT3
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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