Reviewed, UniProtKB/Swiss-Prot O68814 (TRPC1_STRCO)

Names and origin

Protein names

Recommended name:
    Indole-3-glycerol phosphate synthase 1
      Short name=IGPS 1
    EC=4.1.1.48

Gene names

Name:	trpC1
Synonyms:	trpC
Ordered Locus Names:	SCO2039
ORF Names:	SC4G6.08c

Organism

Streptomyces coelicolor [Complete proteome] [HAMAP]

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134
Sequence similarities	Belongs to the trpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Indole-3-glycerol phosphate synthase 1 HAMAP MF_00134		PRO_0000154259
Experimental info
	Sequence conflict	29	1	E → V in AAC63500. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O68814-1 [UniParc]. Last modified December 1, 2000. Version 3. Checksum: 18688CF881D63967	FASTA	269	28,387
	10 20 30 40 50 60 MSVLDEIIDG VRADLAERQA RVSLDELKER AAKARPAKDG VAALRGDGVK VICEVKRSSP 70 80 90 100 110 120 SKGALAAIAD PAGLAADYEA GGAAVISVLT EERRFGGSLA DLDSVRARVD IPVLRKDFIV 130 140 150 160 170 180 TSYQLWEARA HGADLVLLIV AALEQPALES LIERAESIGL TPLVEVHDED EVERAVDAGA 190 200 210 220 230 240 KVIGVNARNL KTLEVDRGTF ERVAPEIPAH IVKVAESGVR GPHDLIAYAN EGADAVLVGE 250 260 SLVTGRDPKT AVSDLVAAGE HPALRHGRS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The expression of the trpD, trpC and trpBA genes of Streptomyces coelicolor A3(2) is regulated by growth rate and growth phase but not by feedback repression." Hu D.S.-J., Hood D.W., Heidstra R., Hodgson D.A. Mol. Microbiol. 32:869-880(1999) [PubMed: 10361288] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: A3(2).
[2]	"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF054585 Genomic DNA. Translation: AAC63500.1. AL939111 Genomic DNA. Translation: CAB51431.1.
PIR	T35068.
RefSeq	NP_626299.1.
3D structure databases
SMR	O68814. Positions 2-256.
ModBase	Search...
Genome annotation databases
GeneID	1097473.
KEGG	sco:SCO2039.
NMPDR	fig|100226.1.peg.2005.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG540956.
OMA	PLVEVHT.
Enzyme and pathway databases
BioCyc	SCOE100226:SCO2039-MONOMER.
BRENDA	4.1.1.48. 1084.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC1_STRCO

Accession

Primary (citable) accession number: O68814
Secondary accession number(s): Q9S2U6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	December 1, 2000
Last modified:	February 9, 2010
This is version 69 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)