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Protein
Submitted name:

Targeted effector protein

Gene

yopH

Organism
Yersinia pestis
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Enzyme and pathway databases

BioCyciYPES214092:GKDD-4274-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Targeted effector proteinImported
Submitted name:
Type III secretion injected virulence proteinImported
Submitted name:
Uncharacterized proteinImported
Submitted name:
YopHImported
Gene namesi
Name:yopHImported
Ordered Locus Names:YP_pCD17Imported, YPCD1.67cImported
Encoded oniPlasmid pCD1Imported
Plasmid pCD1-pMT1Imported
OrganismiYersinia pestisImported
Taxonomic identifieri632 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
Proteomesi
  • UP000000815 Componenti: Plasmid pCD1
  • UP000001019 Componenti: Plasmid pCD1

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3646.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HUFX-ray2.00A1-130[»]
1QZ0X-ray1.50A/B164-468[»]
2Y2FX-ray1.78A164-468[»]
2YDUX-ray1.79A164-468[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini186 – 451266Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini366 – 45186TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST

Phylogenomic databases

HOGENOMiHOG000219626.
OMAiSHVANIV.
OrthoDBiEOG6423BT.

Family and domain databases

Gene3Di3.30.1570.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR015103. ProtTyrPase_YopH_N.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR003546. Tyr_Pase_SptP/YopH.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
PF09013. YopH_N. 1 hit.
[Graphical view]
PRINTSiPR01371. BACYPHPHTASE.
PR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF64449. SSF64449. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O68720-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLSLSDLHR QVSRLVQQES GDCTGKLRGN VAANKETTFQ GLTIASGARE
60 70 80 90 100
SEKVFAQTVL SHVANVVLTQ EDTAKLLQST VKHNLNNYDL RSVGNGNSVL
110 120 130 140 150
VSLRSDQMTL QDAKVLLEAA LRQESGARGH VSSHSHSALH APGTPVREGL
160 170 180 190 200
RSHLDPRTPP LPPRERPHTS GHHGAGEARA TAPSTVSPYG PEARAELSSR
210 220 230 240 250
LTTLRNTLAP ATNDPRYLQA CGGEKLNRFR DIQCCRQTAV RADLNANYIQ
260 270 280 290 300
VGNTRTIACQ YPLQSQLESH FRMLAENRTP VLAVLASSSE IANQRFGMPD
310 320 330 340 350
YFRQSGTYGS ITVESKMTQQ VGLGDGIMAD MYTLTIREAG QKTISVPVVH
360 370 380 390 400
VGNWPDQTAV SSEVTKALAS LVDQTAETKR NMYESKGSSA VGDDSKLRPV
410 420 430 440 450
IHCRAGVGRT AQLIGAMCMN DSRNSQLSVE DMVSQMRVQR NGIMVQKDEQ
460
LDVLIKLAEG QGRPLLNS
Length:468
Mass (Da):50,869
Last modified:August 1, 1998 - v1
Checksum:i9EA639C08197EA81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053946 Genomic DNA. Translation: AAC62606.1.
AF074612 Genomic DNA. Translation: AAC69768.1.
AE017043 Genomic DNA. Translation: AAS58536.1.
HQ612242 Genomic DNA. Translation: ADV16630.1.
AL117189 Genomic DNA. Translation: CAB54944.1.
PIRiT43622.
RefSeqiNP_395201.1. NC_003131.1.
NP_857779.1. NC_004836.1.
NP_857910.1. NC_004839.1.
WP_002213278.1. NZ_LIXY01000017.1.

Genome annotation databases

EnsemblBacteriaiAAS58536; AAS58536; YP_pCD17.
KNX91383; KNX91383; ACX52_4259.
KNX91504; KNX91504; ACX54_4296.
GeneIDi1149274.
1172712.
15151821.
KEGGipg:1149274.
pg:15151821.
ype:YPCD1.67c.
ypj:CH55_4361.
ypl:CH46_4374.
ypm:YP_pCD17.
ypv:BZ15_4329.
ypw:CH59_4415.
PATRICi18588664. VBIYerPes7843_0077.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053946 Genomic DNA. Translation: AAC62606.1.
AF074612 Genomic DNA. Translation: AAC69768.1.
AE017043 Genomic DNA. Translation: AAS58536.1.
HQ612242 Genomic DNA. Translation: ADV16630.1.
AL117189 Genomic DNA. Translation: CAB54944.1.
PIRiT43622.
RefSeqiNP_395201.1. NC_003131.1.
NP_857779.1. NC_004836.1.
NP_857910.1. NC_004839.1.
WP_002213278.1. NZ_LIXY01000017.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HUFX-ray2.00A1-130[»]
1QZ0X-ray1.50A/B164-468[»]
2Y2FX-ray1.78A164-468[»]
2YDUX-ray1.79A164-468[»]
ModBaseiSearch...
MobiDBiSearch...

Chemistry

ChEMBLiCHEMBL3646.

Protocols and materials databases

DNASUi1149274.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAS58536; AAS58536; YP_pCD17.
KNX91383; KNX91383; ACX52_4259.
KNX91504; KNX91504; ACX54_4296.
GeneIDi1149274.
1172712.
15151821.
KEGGipg:1149274.
pg:15151821.
ype:YPCD1.67c.
ypj:CH55_4361.
ypl:CH46_4374.
ypm:YP_pCD17.
ypv:BZ15_4329.
ypw:CH59_4415.
PATRICi18588664. VBIYerPes7843_0077.

Phylogenomic databases

HOGENOMiHOG000219626.
OMAiSHVANIV.
OrthoDBiEOG6423BT.

Enzyme and pathway databases

BioCyciYPES214092:GKDD-4274-MONOMER.

Family and domain databases

Gene3Di3.30.1570.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR015103. ProtTyrPase_YopH_N.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR003546. Tyr_Pase_SptP/YopH.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
PF09013. YopH_N. 1 hit.
[Graphical view]
PRINTSiPR01371. BACYPHPHTASE.
PR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF64449. SSF64449. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequencing and analysis of the low-Ca2+-response plasmid pCD1 of Yersinia pestis KIM5."
    Perry R.D., Straley S.C., Fetherston J.D., Rose D.J., Gregor J., Blattner F.R.
    Infect. Immun. 66:4611-4623(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: KIM5Imported.
    Plasmid: pCD1
  2. "Structural organization of virulence-associated plasmids of Yersinia pestis."
    Hu P., Elliott J., McCready P., Skowronski E., Garnes J., Kobayashi A., Brubaker R.R., Garcia E.
    J. Bacteriol. 180:5192-5202(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: KIM5Imported.
    Plasmid: pCD1
  3. "Structure of the N-terminal domain of Yersinia pestis YopH at 2.0 A resolution."
    Evdokimov A.G., Tropea J.E., Routzahn K.M., Copeland T.D., Waugh D.S.
    Acta Crystallogr. D 57:793-799(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1-130.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CO-92Imported and CO-92 / Biovar OrientalisImported.
    Plasmid: pCD1
  5. "High-resolution structure of the Yersinia pestis protein tyrosine phosphatase YopH in complex with a phosphotyrosyl mimetic-containing hexapeptide."
    Phan J., Lee K., Cherry S., Tropea J.E., Burke T.R., Waugh D.S.
    Biochemistry 42:13113-13121(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 164-468.
  6. "Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans."
    Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D., Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L., Dai R.
    , Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H., Wang J., Huang P., Yang R.
    DNA Res. 11:179-197(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 91001Imported and 91001 / Biovar MediaevalisImported.
    Plasmid: pCD1
  7. "Characterization of pPCP1 Plasmids in Yersinia pestis Strains Isolated from the Former Soviet Union."
    Rajanna C., Revazishvili T., Rashid M.H., Chubinidze S., Bakanidze L., Tsanava S., Imnadze P., Bishop-Lilly K.A., Sozhamannan S., Gibbons H.S., Morris J.G., Sulakvelidze A.
    Int J Microbiol 2010:760819-760819(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C790Imported.
    Plasmid: pCD1-pMT1
  8. "Isothiazolidinone (IZD) as a phosphoryl mimetic in inhibitors of the Yersinia pestis protein tyrosine phosphatase YopH."
    Kim S.E., Bahta M., Lountos G.T., Ulrich R.G., Burke T.R., Waugh D.S.
    Acta Crystallogr. D 67:639-645(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.79 ANGSTROMS) OF 164-468.
  9. "Utilization of nitrophenylphosphates and oxime-based ligation for the development of nanomolar affinity inhibitors of the Yersinia pestis outer protein H (YopH) phosphatase."
    Bahta M., Lountos G.T., Dyas B., Kim S.E., Ulrich R.G., Waugh D.S., Burke T.R.
    J. Med. Chem. 54:2933-2943(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.78 ANGSTROMS) OF 164-468.

Entry informationi

Entry nameiO68720_YERPE
AccessioniPrimary (citable) accession number: O68720
Secondary accession number(s): Q74YY5, Q7ARH8
Entry historyi
Integrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, PlasmidImported, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.