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Protein

Lantibiotic mutacin-1140

Gene

lanA

Organism
Streptococcus mutans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Bacteriocin, Lantibiotic

Protein family/group databases

TCDBi1.C.20.1.8 the nisin (nisin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Lantibiotic mutacin-1140
Alternative name(s):
Mutacin III
Gene namesi
Name:lanA
Synonyms:mutA
OrganismiStreptococcus mutans
Taxonomic identifieri1309 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000171301 – 411 PublicationAdd BLAST41
PeptideiPRO_000001713142 – 63Lantibiotic mutacin-1140Add BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki44 ↔ 48Lanthionine (Ser-Cys)1 Publication
Modified residuei462,3-didehydroalanine (Ser)1 Publication1
Cross-linki49 ↔ 52Beta-methyllanthionine (Thr-Cys)1 Publication
Modified residuei552,3-didehydrobutyrine1 Publication1
Cross-linki57 ↔ 62Lanthionine (Ser-Cys)1 Publication
Cross-linki60 ↔ 63S-(2-aminovinyl)-D-cysteine (Ser-Cys)1 Publication

Post-translational modificationi

Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. The C-terminal lanthionine undergoes decarboxylation. This is followed by membrane translocation and cleavage of the modified precursor.
The structure of the 2,3-didehydrobutyrine is not discussed in PubMed:11082191.

Keywords - PTMi

D-amino acid, Thioether bond

Miscellaneous databases

PMAP-CutDBiO68586

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the type A lantibiotic family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR006079 Lantibiotic_typ-A_Bacillales
PfamiView protein in Pfam
PF02052 Gallidermin, 1 hit
PRINTSiPR00323 GALLIDERMIN
TIGRFAMsiTIGR03731 lantibio_gallid, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O68586-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTQLLEVL GTETFDVQED LFAFDTTDTT IVASNDDPDT RFKSWSLCTP
60
GCARTGSFNS YCC
Length:63
Mass (Da):6,968
Last modified:August 1, 1998 - v1
Checksum:iED9BC73771758489
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051560 Genomic DNA Translation: AAC18827.1
AF154675 Genomic DNA Translation: AAD56142.1
RefSeqiWP_002268802.1, NZ_LTAK01000001.1

Similar proteinsi

Entry informationi

Entry nameiLANN_STRMG
AccessioniPrimary (citable) accession number: O68586
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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