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Protein

Probable manganese-dependent inorganic pyrophosphatase

Gene

ppaC

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Manganese 11
Metal bindingi13Manganese 11
Metal bindingi15Manganese 21
Metal bindingi76Manganese 11
Metal bindingi76Manganese 21
Metal bindingi98Manganese 21
Metal bindingi150Manganese 21

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable manganese-dependent inorganic pyrophosphatase (EC:3.6.1.1)
Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name:
PPase
Gene namesi
Name:ppaC
Synonyms:dlt5, ppx1
Ordered Locus Names:SMU_1687
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002512 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001585901 – 310Probable manganese-dependent inorganic pyrophosphataseAdd BLAST310

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi210007.SMU_1687.

Structurei

Secondary structure

1310
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 7Combined sources4
Helixi14 – 29Combined sources16
Beta strandi34 – 36Combined sources3
Beta strandi38 – 40Combined sources3
Helixi44 – 52Combined sources9
Turni64 – 68Combined sources5
Beta strandi70 – 76Combined sources7
Helixi80 – 82Combined sources3
Helixi87 – 89Combined sources3
Beta strandi90 – 97Combined sources8
Beta strandi111 – 114Combined sources4
Beta strandi116 – 118Combined sources3
Helixi120 – 131Combined sources12
Helixi137 – 151Combined sources15
Turni152 – 155Combined sources4
Helixi163 – 174Combined sources12
Helixi178 – 188Combined sources11
Helixi197 – 200Combined sources4
Beta strandi203 – 210Combined sources8
Beta strandi213 – 223Combined sources11
Helixi225 – 228Combined sources4
Helixi229 – 231Combined sources3
Helixi232 – 246Combined sources15
Beta strandi249 – 257Combined sources9
Turni258 – 261Combined sources4
Beta strandi262 – 269Combined sources8
Helixi272 – 279Combined sources8
Beta strandi287 – 290Combined sources4
Helixi296 – 299Combined sources4
Helixi301 – 308Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I74X-ray2.20A/B2-310[»]
ProteinModelPortaliO68579.
SMRiO68579.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO68579.

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase class C family.Curated

Phylogenomic databases

eggNOGiENOG4105E2M. Bacteria.
COG1227. LUCA.
KOiK15986.
OMAiMLCAILS.
PhylomeDBiO68579.

Family and domain databases

HAMAPiMF_00207. PPase_C. 1 hit.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O68579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKILVFGHQ NPDSDAIGSS MAYAYLKRQL GVDAQAVALG NPNEETAFVL
60 70 80 90 100
DYFGIQAPPV VKSAQAEGAK QVILTDHNEF QQSIADIREV EVVEVVDHHR
110 120 130 140 150
VANFETANPL YMRLEPVGSA SSIVYRLYKE NGVAIPKEIA GVMLSGLISD
160 170 180 190 200
TLLLKSPTTH ASDPAVAEDL AKIAGVDLQE YGLAMLKAGT NLASKTAAQL
210 220 230 240 250
VDIDAKTFEL NGSQVRVAQV NTVDINEVLE RQNEIEEAIK ASQAANGYSD
260 270 280 290 300
FVLMITDILN SNSEILALGN NTDKVEAAFN FTLKNNHAFL AGAVSRKKQV
310
VPQLTESFNG
Length:310
Mass (Da):33,403
Last modified:August 1, 1998 - v1
Checksum:i307A318A2A1CEA71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051356 Genomic DNA. Translation: AAC05778.1.
AF050517 Genomic DNA. Translation: AAC29042.1.
AE014133 Genomic DNA. Translation: AAN59324.1.
RefSeqiNP_722018.1. NC_004350.2.
WP_002262586.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN59324; AAN59324; SMU_1687.
GeneIDi1028922.
KEGGismu:SMU_1687.
PATRICi19665357. VBIStrMut61772_1507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051356 Genomic DNA. Translation: AAC05778.1.
AF050517 Genomic DNA. Translation: AAC29042.1.
AE014133 Genomic DNA. Translation: AAN59324.1.
RefSeqiNP_722018.1. NC_004350.2.
WP_002262586.1. NC_004350.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I74X-ray2.20A/B2-310[»]
ProteinModelPortaliO68579.
SMRiO68579.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi210007.SMU_1687.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN59324; AAN59324; SMU_1687.
GeneIDi1028922.
KEGGismu:SMU_1687.
PATRICi19665357. VBIStrMut61772_1507.

Phylogenomic databases

eggNOGiENOG4105E2M. Bacteria.
COG1227. LUCA.
KOiK15986.
OMAiMLCAILS.
PhylomeDBiO68579.

Miscellaneous databases

EvolutionaryTraceiO68579.

Family and domain databases

HAMAPiMF_00207. PPase_C. 1 hit.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPAC_STRMU
AccessioniPrimary (citable) accession number: O68579
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.