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Protein

Probable manganese-dependent inorganic pyrophosphatase

Gene

ppaC

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi9 – 91Manganese 1
Metal bindingi13 – 131Manganese 1
Metal bindingi15 – 151Manganese 2
Metal bindingi76 – 761Manganese 1
Metal bindingi76 – 761Manganese 2
Metal bindingi98 – 981Manganese 2
Metal bindingi150 – 1501Manganese 2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-1579-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable manganese-dependent inorganic pyrophosphatase (EC:3.6.1.1)
Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name:
PPase
Gene namesi
Name:ppaC
Synonyms:dlt5, ppx1
Ordered Locus Names:SMU_1687
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002512 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Probable manganese-dependent inorganic pyrophosphatasePRO_0000158590Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi210007.SMU_1687.

Structurei

Secondary structure

1
310
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 74Combined sources
Helixi14 – 2916Combined sources
Beta strandi34 – 363Combined sources
Beta strandi38 – 403Combined sources
Helixi44 – 529Combined sources
Turni64 – 685Combined sources
Beta strandi70 – 767Combined sources
Helixi80 – 823Combined sources
Helixi87 – 893Combined sources
Beta strandi90 – 978Combined sources
Beta strandi111 – 1144Combined sources
Beta strandi116 – 1183Combined sources
Helixi120 – 13112Combined sources
Helixi137 – 15115Combined sources
Turni152 – 1554Combined sources
Helixi163 – 17412Combined sources
Helixi178 – 18811Combined sources
Helixi197 – 2004Combined sources
Beta strandi203 – 2108Combined sources
Beta strandi213 – 22311Combined sources
Helixi225 – 2284Combined sources
Helixi229 – 2313Combined sources
Helixi232 – 24615Combined sources
Beta strandi249 – 2579Combined sources
Turni258 – 2614Combined sources
Beta strandi262 – 2698Combined sources
Helixi272 – 2798Combined sources
Beta strandi287 – 2904Combined sources
Helixi296 – 2994Combined sources
Helixi301 – 3088Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I74X-ray2.20A/B2-310[»]
ProteinModelPortaliO68579.
SMRiO68579. Positions 2-310.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO68579.

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase class C family.Curated

Phylogenomic databases

eggNOGiENOG4105E2M. Bacteria.
COG1227. LUCA.
KOiK15986.
OMAiMLCAILS.
PhylomeDBiO68579.

Family and domain databases

HAMAPiMF_00207. PPase_C. 1 hit.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O68579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKILVFGHQ NPDSDAIGSS MAYAYLKRQL GVDAQAVALG NPNEETAFVL
60 70 80 90 100
DYFGIQAPPV VKSAQAEGAK QVILTDHNEF QQSIADIREV EVVEVVDHHR
110 120 130 140 150
VANFETANPL YMRLEPVGSA SSIVYRLYKE NGVAIPKEIA GVMLSGLISD
160 170 180 190 200
TLLLKSPTTH ASDPAVAEDL AKIAGVDLQE YGLAMLKAGT NLASKTAAQL
210 220 230 240 250
VDIDAKTFEL NGSQVRVAQV NTVDINEVLE RQNEIEEAIK ASQAANGYSD
260 270 280 290 300
FVLMITDILN SNSEILALGN NTDKVEAAFN FTLKNNHAFL AGAVSRKKQV
310
VPQLTESFNG
Length:310
Mass (Da):33,403
Last modified:August 1, 1998 - v1
Checksum:i307A318A2A1CEA71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051356 Genomic DNA. Translation: AAC05778.1.
AF050517 Genomic DNA. Translation: AAC29042.1.
AE014133 Genomic DNA. Translation: AAN59324.1.
RefSeqiNP_722018.1. NC_004350.2.
WP_002262586.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN59324; AAN59324; SMU_1687.
GeneIDi1028922.
KEGGismu:SMU_1687.
PATRICi19665357. VBIStrMut61772_1507.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051356 Genomic DNA. Translation: AAC05778.1.
AF050517 Genomic DNA. Translation: AAC29042.1.
AE014133 Genomic DNA. Translation: AAN59324.1.
RefSeqiNP_722018.1. NC_004350.2.
WP_002262586.1. NC_004350.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I74X-ray2.20A/B2-310[»]
ProteinModelPortaliO68579.
SMRiO68579. Positions 2-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi210007.SMU_1687.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN59324; AAN59324; SMU_1687.
GeneIDi1028922.
KEGGismu:SMU_1687.
PATRICi19665357. VBIStrMut61772_1507.

Phylogenomic databases

eggNOGiENOG4105E2M. Bacteria.
COG1227. LUCA.
KOiK15986.
OMAiMLCAILS.
PhylomeDBiO68579.

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-1579-MONOMER.

Miscellaneous databases

EvolutionaryTraceiO68579.

Family and domain databases

HAMAPiMF_00207. PPase_C. 1 hit.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPAC_STRMU
AccessioniPrimary (citable) accession number: O68579
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: September 7, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.