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Protein

HTH-type transcriptional repressor PurR

Gene

purR

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.UniRule annotation

Pathwayi: purine nucleotide biosynthesis

This protein regulates the pathway purine nucleotide biosynthesis, which is part of Purine metabolism.
View all proteins of this organism that are known to be involved in the pathway purine nucleotide biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei73CorepressorUniRule annotation1
Binding sitei190CorepressorUniRule annotation1
Binding sitei192CorepressorUniRule annotation1
Binding sitei221CorepressorUniRule annotation1
Binding sitei275CorepressorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi4 – 23H-T-H motifUniRule annotationAdd BLAST20
DNA bindingi48 – 56UniRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Purine biosynthesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

UniPathwayiUPA00488.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional repressor PurRUniRule annotation
Alternative name(s):
Pur regulon repressorUniRule annotation
Purine nucleotide synthesis repressorUniRule annotation
Gene namesi
Name:purRUniRule annotation
Ordered Locus Names:STM1430
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001079812 – 341HTH-type transcriptional repressor PurRAdd BLAST340

Proteomic databases

PaxDbiO68446.
PRIDEiO68446.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi99287.STM1430.

Structurei

3D structure databases

ProteinModelPortaliO68446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 56HTH lacI-typeUniRule annotationAdd BLAST55

Domaini

Consists of two structural and functional domains: an N-terminal DNA-binding domain, approximately the first 60 residues, and a larger C-terminal domain, approximately 280 residues, which imparts the function of corepressor binding and oligomerization.UniRule annotation

Sequence similaritiesi

Contains 1 HTH lacI-type DNA-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105ETE. Bacteria.
COG1609. LUCA.
HOGENOMiHOG000220180.
KOiK03604.
OMAiCSEYPES.
PhylomeDBiO68446.

Family and domain databases

CDDicd01392. HTH_LacI. 1 hit.
Gene3Di1.10.260.40. 1 hit.
HAMAPiMF_01277. HTH_type_PurR. 1 hit.
InterProiIPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
IPR023588. Tscrpt_reg_HTH_PurR.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
[Graphical view]
PRINTSiPR00036. HTHLACI.
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O68446-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIKDVAKR ANVSTTTVSH VINKTRFVAE ETRNAVWAAI KELHYSPSAV
60 70 80 90 100
ARSLKVNHTK SIGLLATSSE AAYFAEIIEA VEKNCFQKGY TLILGNAWNN
110 120 130 140 150
LEKQRAYLSM MAQKRVDGLL VMCSEYPEPL LSMLEEYRHI PMVVMDWGEA
160 170 180 190 200
KADFTDTVID NAFAGGYMAG RYLVERGHRD IGVIPGPLER NTGAGRLAGF
210 220 230 240 250
MKAMEEALIN VPDNWIVQGD FEPESGYHAM QQILSQSHRP TAVFCGGDIM
260 270 280 290 300
AMGALCAADE MGLRVPQDVS VIGYDNVRNA RYFTPALTTI HQPKDSLGET
310 320 330 340
AFNMLLDRIV NKREESQSIE VHPRLVERRS VADGPFRDYR R
Length:341
Mass (Da):38,048
Last modified:January 23, 2007 - v3
Checksum:i23C0C9B7E8B222DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040636 Genomic DNA. Translation: AAC05741.1.
AE006468 Genomic DNA. Translation: AAL20352.1.
RefSeqiNP_460393.1. NC_003197.1.
WP_000190993.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20352; AAL20352; STM1430.
GeneIDi1252948.
KEGGistm:STM1430.
PATRICi32381343. VBISalEnt20916_1512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF040636 Genomic DNA. Translation: AAC05741.1.
AE006468 Genomic DNA. Translation: AAL20352.1.
RefSeqiNP_460393.1. NC_003197.1.
WP_000190993.1. NC_003197.1.

3D structure databases

ProteinModelPortaliO68446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM1430.

Proteomic databases

PaxDbiO68446.
PRIDEiO68446.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20352; AAL20352; STM1430.
GeneIDi1252948.
KEGGistm:STM1430.
PATRICi32381343. VBISalEnt20916_1512.

Phylogenomic databases

eggNOGiENOG4105ETE. Bacteria.
COG1609. LUCA.
HOGENOMiHOG000220180.
KOiK03604.
OMAiCSEYPES.
PhylomeDBiO68446.

Enzyme and pathway databases

UniPathwayiUPA00488.

Family and domain databases

CDDicd01392. HTH_LacI. 1 hit.
Gene3Di1.10.260.40. 1 hit.
HAMAPiMF_01277. HTH_type_PurR. 1 hit.
InterProiIPR000843. HTH_LacI.
IPR010982. Lambda_DNA-bd_dom.
IPR028082. Peripla_BP_I.
IPR023588. Tscrpt_reg_HTH_PurR.
[Graphical view]
PfamiPF00356. LacI. 1 hit.
[Graphical view]
PRINTSiPR00036. HTHLACI.
SMARTiSM00354. HTH_LACI. 1 hit.
[Graphical view]
SUPFAMiSSF47413. SSF47413. 1 hit.
SSF53822. SSF53822. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS50932. HTH_LACI_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPURR_SALTY
AccessioniPrimary (citable) accession number: O68446
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.