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Protein

60 kDa chaperonin

Gene

groL

Organism
Lactobacillus helveticus (Lactobacillus suntoryeus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA
OrganismiLactobacillus helveticus (Lactobacillus suntoryeus)
Taxonomic identifieri1587 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000633981 – 54060 kDa chaperoninAdd BLAST540

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

STRINGi405566.lhv_0426.

Structurei

3D structure databases

ProteinModelPortaliO68324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O68324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKDIKFSEN ARRSLLKGVD KLADTVKTTI GPKGRNVVLE QSYGNPDITN
60 70 80 90 100
DGVTIAKSIE LKDRYENMGA KLVAEAAQKT NDIAGDGTTT ATVLTQAIAR
110 120 130 140 150
EGMKNVTAGA NPVGIRRGIE KATKAAVDEL HKISHKVESK DQIANVAAVS
160 170 180 190 200
SASKEIGALI ADAMEKVGHD GVITIEDSRG INTELSVVEG MQFDRGYLSQ
210 220 230 240 250
YMVTDNDKME ADLDNPYILI TDKKISNIQD ILPLLQEIVQ QGKSLLIIAD
260 270 280 290 300
DITGEALPTL VLNKIRGTFN VVAVKAPGFG DRRKAQLQDI AALTGGTVIT
310 320 330 340 350
EDLGLELKDT KIDQLGQARR ITVTKDSTTI VGGAGSKEAI DERVDTIRKQ
360 370 380 390 400
IEDSTSDFDK KKLQERLAKL TGGVAVIHVG AATETELKER RYRIEDALNS
410 420 430 440 450
TRAAVDEGYV AGGGTALVNV EKAVREVKGE TTDEQTGINI VLRALSAPVR
460 470 480 490 500
QIAENAGKDG SVILDKLEHQ ENEIGYNAAT DKWENMVDAG IIDPTKVTRT
510 520 530 540
ALQNAASIAA LLLTTEAVVA EIPEPKQAAP QGGAGAPMGM
Length:540
Mass (Da):57,638
Last modified:August 1, 1998 - v1
Checksum:i4257DDB45FC7C4B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031929 Genomic DNA. Translation: AAC29004.1.
RefSeqiWP_003627769.1. NZ_LSVJ01000297.1.

Genome annotation databases

GeneIDi16794599.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031929 Genomic DNA. Translation: AAC29004.1.
RefSeqiWP_003627769.1. NZ_LSVJ01000297.1.

3D structure databases

ProteinModelPortaliO68324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi405566.lhv_0426.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16794599.

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCH60_LACHE
AccessioniPrimary (citable) accession number: O68324
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: August 1, 1998
Last modified: October 5, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.