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Protein

60 kDa chaperonin

Gene

groL

Organism
Lactobacillus helveticus (Lactobacillus suntoryeus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • positive regulation of interleukin-8 secretion Source: CAFA
  • protein refolding Source: InterPro

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA
OrganismiLactobacillus helveticus (Lactobacillus suntoryeus)
Taxonomic identifieri1587 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000633981 – 54060 kDa chaperoninAdd BLAST540

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO68324
SMRiO68324
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9 Bacteria
COG0459 LUCA

Family and domain databases

CDDicd03344 GroEL, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
HAMAPiMF_00600 CH60, 1 hit
InterProiView protein in InterPro
IPR018370 Chaperonin_Cpn60_CS
IPR001844 Chaprnin_Cpn60
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00298 CHAPERONIN60
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02348 GroEL, 1 hit
PROSITEiView protein in PROSITE
PS00296 CHAPERONINS_CPN60, 1 hit

Sequencei

Sequence statusi: Complete.

O68324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKDIKFSEN ARRSLLKGVD KLADTVKTTI GPKGRNVVLE QSYGNPDITN
60 70 80 90 100
DGVTIAKSIE LKDRYENMGA KLVAEAAQKT NDIAGDGTTT ATVLTQAIAR
110 120 130 140 150
EGMKNVTAGA NPVGIRRGIE KATKAAVDEL HKISHKVESK DQIANVAAVS
160 170 180 190 200
SASKEIGALI ADAMEKVGHD GVITIEDSRG INTELSVVEG MQFDRGYLSQ
210 220 230 240 250
YMVTDNDKME ADLDNPYILI TDKKISNIQD ILPLLQEIVQ QGKSLLIIAD
260 270 280 290 300
DITGEALPTL VLNKIRGTFN VVAVKAPGFG DRRKAQLQDI AALTGGTVIT
310 320 330 340 350
EDLGLELKDT KIDQLGQARR ITVTKDSTTI VGGAGSKEAI DERVDTIRKQ
360 370 380 390 400
IEDSTSDFDK KKLQERLAKL TGGVAVIHVG AATETELKER RYRIEDALNS
410 420 430 440 450
TRAAVDEGYV AGGGTALVNV EKAVREVKGE TTDEQTGINI VLRALSAPVR
460 470 480 490 500
QIAENAGKDG SVILDKLEHQ ENEIGYNAAT DKWENMVDAG IIDPTKVTRT
510 520 530 540
ALQNAASIAA LLLTTEAVVA EIPEPKQAAP QGGAGAPMGM
Length:540
Mass (Da):57,638
Last modified:August 1, 1998 - v1
Checksum:i4257DDB45FC7C4B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF031929 Genomic DNA Translation: AAC29004.1
RefSeqiWP_003627769.1, NZ_PJRL01000025.1

Genome annotation databases

PATRICifig|1587.23.peg.443

Similar proteinsi

Entry informationi

Entry nameiCH60_LACHE
AccessioniPrimary (citable) accession number: O68324
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: August 1, 1998
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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