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Protein

60 kDa chaperonin

Gene

groL

Organism
Aeromonas salmonicida
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation, mopA
OrganismiAeromonas salmonicida
Taxonomic identifieri645 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAeromonadalesAeromonadaceaeAeromonas

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000632551 – 54460 kDa chaperoninAdd BLAST544

Proteomic databases

PRIDEiO68309.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO68309.
SMRiO68309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

O68309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKEVKFGN EARIKMLEGV NILADAVKVT LGPKGRNVVL DKSFGAPTIT
60 70 80 90 100
KDGVSVAREI ELEDKFQNMG AQMVKEVASK ANDAAGDGTT TATVLAQAIV
110 120 130 140 150
NEGLKAVAAG MNPMDLKRGI DKAVIAAVAE LQVLSQPCAD NNAIAQVGTI
160 170 180 190 200
SANSDEKVGR LIAEAMDKVG RDGVITVEDG QGLDDELAVV EGMQFDRGYL
210 220 230 240 250
SPYFVNKPET GAVELDDPFI LLVDKKVSNI REMLPVLEGV AKAGKPLLIV
260 270 280 290 300
AEDVEGEALA TLVVNTMRGI VKVAAVKAPG FGDRRKAMLQ DIAMLTSGGT
310 320 330 340 350
VIEEVGMELE KATLEDLGRA KRIVITKENT TIIDGVGDAA LIESRVAQIR
360 370 380 390 400
QQIEETSSDY DREKLQERVA KLAGGVAVIK VGAATEVEMK EKKARVDDAL
410 420 430 440 450
HATRAAVEEG VVAGGGVALV RVAAKLAGLR GDNEDQNVGI KVALRAMEAP
460 470 480 490 500
LRQIVINAGE EASVIANAVK NGEGNFGYNA YTEQYGDMLA MGILDPTKVT
510 520 530 540
RSALQFASSI AGLMITTECM ITELPKKDTP AMPDMGGMGG MGMM
Length:544
Mass (Da):57,320
Last modified:August 1, 1998 - v1
Checksum:i2165A80B2B882D59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030975 Genomic DNA. Translation: AAC09226.1.

Similar proteinsi

Entry informationi

Entry nameiCH60_AERSA
AccessioniPrimary (citable) accession number: O68309
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: September 27, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families