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O68283

- ALKD_PSEAE

UniProt

O68283 - ALKD_PSEAE

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Protein

2-dehydro-3-deoxy-phosphogluconate aldolase

Gene
eda, PA3181
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521 By similarity
Active sitei136 – 1361Schiff-base intermediate with substrate By similarity

GO - Molecular functioni

  1. 2-dehydro-3-deoxy-phosphogluconate aldolase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3709-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-dehydro-3-deoxy-phosphogluconate aldolase (EC:4.1.2.14)
Alternative name(s):
KDPG-aldolase
Phospho-2-dehydro-3-deoxygluconate aldolase
Phospho-2-keto-3-deoxygluconate aldolase
Gene namesi
Name:eda
Ordered Locus Names:PA3181
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA3181.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2202202-dehydro-3-deoxy-phosphogluconate aldolasePRO_0000287743Add
BLAST

Interactioni

Subunit structurei

Homotrimer By similarity.

Protein-protein interaction databases

STRINGi208964.PA3181.

Structurei

3D structure databases

ProteinModelPortaliO68283.
SMRiO68283. Positions 3-211.

Family & Domainsi

Sequence similaritiesi

Belongs to the KHG/KDPG aldolase family.

Phylogenomic databases

eggNOGiCOG0800.
HOGENOMiHOG000233114.
KOiK01625.
OMAiDILPMAD.
OrthoDBiEOG67DPKT.
PhylomeDBiO68283.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view]
PfamiPF01081. Aldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01182. eda. 1 hit.
PROSITEiPS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O68283-1 [UniParc]FASTAAdd to Basket

« Hide

MHNLEQKTAR IDTLCREARI LPVITIDREA DILPMADALA AGGLTALEIT    50
LRTAHGLTAI RRLSEERPHL RIGAGTVLDP RTFAAAEKAG ASFVVTPGCT 100
DELLRFALDS EVPLLPGVAS ASEIMLAYRH GYRRFKLFPA EVSGGPAALK 150
AFSGPFPDIR FCPTGGVSLN NLADYLAVPN VMCVGGTWML PKAVVDRGDW 200
AQVERLSREA LERFAEHRRH 220
Length:220
Mass (Da):23,954
Last modified:May 1, 1999 - v2
Checksum:iE130639230FBA58F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF029673 Genomic DNA. Translation: AAC38312.2.
AE004091 Genomic DNA. Translation: AAG06569.1.
PIRiG83247.
RefSeqiNP_251871.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG06569; AAG06569; PA3181.
GeneIDi882580.
KEGGipae:PA3181.
PATRICi19840929. VBIPseAer58763_3325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF029673 Genomic DNA. Translation: AAC38312.2 .
AE004091 Genomic DNA. Translation: AAG06569.1 .
PIRi G83247.
RefSeqi NP_251871.1. NC_002516.2.

3D structure databases

ProteinModelPortali O68283.
SMRi O68283. Positions 3-211.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA3181.

Protocols and materials databases

DNASUi 882580.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG06569 ; AAG06569 ; PA3181 .
GeneIDi 882580.
KEGGi pae:PA3181.
PATRICi 19840929. VBIPseAer58763_3325.

Organism-specific databases

PseudoCAPi PA3181.

Phylogenomic databases

eggNOGi COG0800.
HOGENOMi HOG000233114.
KOi K01625.
OMAi DILPMAD.
OrthoDBi EOG67DPKT.
PhylomeDBi O68283.

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-3709-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view ]
Pfami PF01081. Aldolase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01182. eda. 1 hit.
PROSITEi PS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "HexR, zwf, and eda genes."
    Hager P.W., Dail M.B., Phibbs P.V. Jr.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiALKD_PSEAE
AccessioniPrimary (citable) accession number: O68283
Secondary accession number(s): Q7DCB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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