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O68283

- ALKD_PSEAE

UniProt

O68283 - ALKD_PSEAE

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Protein

2-dehydro-3-deoxy-phosphogluconate aldolase

Gene

eda

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521PROSITE-ProRule annotation
Active sitei136 – 1361Schiff-base intermediate with substratePROSITE-ProRule annotation

GO - Molecular functioni

  1. 2-dehydro-3-deoxy-phosphogluconate aldolase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3709-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-dehydro-3-deoxy-phosphogluconate aldolase (EC:4.1.2.14)
Alternative name(s):
KDPG-aldolase
Phospho-2-dehydro-3-deoxygluconate aldolase
Phospho-2-keto-3-deoxygluconate aldolase
Gene namesi
Name:eda
Ordered Locus Names:PA3181
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA3181.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2202202-dehydro-3-deoxy-phosphogluconate aldolasePRO_0000287743Add
BLAST

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi208964.PA3181.

Structurei

3D structure databases

ProteinModelPortaliO68283.
SMRiO68283. Positions 3-211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KHG/KDPG aldolase family.Curated

Phylogenomic databases

eggNOGiCOG0800.
HOGENOMiHOG000233114.
InParanoidiO68283.
KOiK01625.
OMAiDILPMAD.
OrthoDBiEOG67DPKT.
PhylomeDBiO68283.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view]
PfamiPF01081. Aldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01182. eda. 1 hit.
PROSITEiPS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O68283-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHNLEQKTAR IDTLCREARI LPVITIDREA DILPMADALA AGGLTALEIT
60 70 80 90 100
LRTAHGLTAI RRLSEERPHL RIGAGTVLDP RTFAAAEKAG ASFVVTPGCT
110 120 130 140 150
DELLRFALDS EVPLLPGVAS ASEIMLAYRH GYRRFKLFPA EVSGGPAALK
160 170 180 190 200
AFSGPFPDIR FCPTGGVSLN NLADYLAVPN VMCVGGTWML PKAVVDRGDW
210 220
AQVERLSREA LERFAEHRRH
Length:220
Mass (Da):23,954
Last modified:May 1, 1999 - v2
Checksum:iE130639230FBA58F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029673 Genomic DNA. Translation: AAC38312.2.
AE004091 Genomic DNA. Translation: AAG06569.1.
PIRiG83247.
RefSeqiNP_251871.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG06569; AAG06569; PA3181.
GeneIDi882580.
KEGGipae:PA3181.
PATRICi19840929. VBIPseAer58763_3325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029673 Genomic DNA. Translation: AAC38312.2 .
AE004091 Genomic DNA. Translation: AAG06569.1 .
PIRi G83247.
RefSeqi NP_251871.1. NC_002516.2.

3D structure databases

ProteinModelPortali O68283.
SMRi O68283. Positions 3-211.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 208964.PA3181.

Protocols and materials databases

DNASUi 882580.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAG06569 ; AAG06569 ; PA3181 .
GeneIDi 882580.
KEGGi pae:PA3181.
PATRICi 19840929. VBIPseAer58763_3325.

Organism-specific databases

PseudoCAPi PA3181.

Phylogenomic databases

eggNOGi COG0800.
HOGENOMi HOG000233114.
InParanoidi O68283.
KOi K01625.
OMAi DILPMAD.
OrthoDBi EOG67DPKT.
PhylomeDBi O68283.

Enzyme and pathway databases

BioCyci RETL1328306-WGS:GSTH-3709-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view ]
Pfami PF01081. Aldolase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01182. eda. 1 hit.
PROSITEi PS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "HexR, zwf, and eda genes."
    Hager P.W., Dail M.B., Phibbs P.V. Jr.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiALKD_PSEAE
AccessioniPrimary (citable) accession number: O68283
Secondary accession number(s): Q7DCB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3