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Protein

2-dehydro-3-deoxy-phosphogluconate aldolase

Gene

eda

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei52 – 521PROSITE-ProRule annotation
Active sitei136 – 1361Schiff-base intermediate with substratePROSITE-ProRule annotation

GO - Molecular functioni

  1. 2-dehydro-3-deoxy-phosphogluconate aldolase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3709-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-dehydro-3-deoxy-phosphogluconate aldolase (EC:4.1.2.14)
Alternative name(s):
KDPG-aldolase
Phospho-2-dehydro-3-deoxygluconate aldolase
Phospho-2-keto-3-deoxygluconate aldolase
Gene namesi
Name:eda
Ordered Locus Names:PA3181
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
ProteomesiUP000002438: Chromosome

Organism-specific databases

PseudoCAPiPA3181.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2202202-dehydro-3-deoxy-phosphogluconate aldolasePRO_0000287743Add
BLAST

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi208964.PA3181.

Structurei

3D structure databases

ProteinModelPortaliO68283.
SMRiO68283. Positions 3-211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KHG/KDPG aldolase family.Curated

Phylogenomic databases

eggNOGiCOG0800.
HOGENOMiHOG000233114.
InParanoidiO68283.
KOiK01625.
OMAiMALPNVM.
OrthoDBiEOG67DPKT.
PhylomeDBiO68283.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view]
PfamiPF01081. Aldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01182. eda. 1 hit.
PROSITEiPS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O68283-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHNLEQKTAR IDTLCREARI LPVITIDREA DILPMADALA AGGLTALEIT
60 70 80 90 100
LRTAHGLTAI RRLSEERPHL RIGAGTVLDP RTFAAAEKAG ASFVVTPGCT
110 120 130 140 150
DELLRFALDS EVPLLPGVAS ASEIMLAYRH GYRRFKLFPA EVSGGPAALK
160 170 180 190 200
AFSGPFPDIR FCPTGGVSLN NLADYLAVPN VMCVGGTWML PKAVVDRGDW
210 220
AQVERLSREA LERFAEHRRH
Length:220
Mass (Da):23,954
Last modified:May 1, 1999 - v2
Checksum:iE130639230FBA58F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029673 Genomic DNA. Translation: AAC38312.2.
AE004091 Genomic DNA. Translation: AAG06569.1.
PIRiG83247.
RefSeqiNP_251871.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG06569; AAG06569; PA3181.
GeneIDi882580.
KEGGipae:PA3181.
PATRICi19840929. VBIPseAer58763_3325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF029673 Genomic DNA. Translation: AAC38312.2.
AE004091 Genomic DNA. Translation: AAG06569.1.
PIRiG83247.
RefSeqiNP_251871.1. NC_002516.2.

3D structure databases

ProteinModelPortaliO68283.
SMRiO68283. Positions 3-211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA3181.

Protocols and materials databases

DNASUi882580.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG06569; AAG06569; PA3181.
GeneIDi882580.
KEGGipae:PA3181.
PATRICi19840929. VBIPseAer58763_3325.

Organism-specific databases

PseudoCAPiPA3181.

Phylogenomic databases

eggNOGiCOG0800.
HOGENOMiHOG000233114.
InParanoidiO68283.
KOiK01625.
OMAiMALPNVM.
OrthoDBiEOG67DPKT.
PhylomeDBiO68283.

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-3709-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view]
PfamiPF01081. Aldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01182. eda. 1 hit.
PROSITEiPS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "HexR, zwf, and eda genes."
    Hager P.W., Dail M.B., Phibbs P.V. Jr.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiALKD_PSEAE
AccessioniPrimary (citable) accession number: O68283
Secondary accession number(s): Q7DCB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 1, 1999
Last modified: January 7, 2015
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.