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O68283 (ALKD_PSEAE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-dehydro-3-deoxy-phosphogluconate aldolase

EC=4.1.2.14
Alternative name(s):
KDPG-aldolase
Phospho-2-dehydro-3-deoxygluconate aldolase
Phospho-2-keto-3-deoxygluconate aldolase
Gene names
Name:eda
Ordered Locus Names:PA3181
OrganismPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) [Reference proteome] [HAMAP]
Taxonomic identifier208964 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.

Subunit structure

Homotrimer By similarity.

Sequence similarities

Belongs to the KHG/KDPG aldolase family.

Ontologies

Keywords
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_function2-dehydro-3-deoxy-phosphogluconate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2202202-dehydro-3-deoxy-phosphogluconate aldolase
PRO_0000287743

Sites

Active site521 By similarity
Active site1361Schiff-base intermediate with substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
O68283 [UniParc].

Last modified May 1, 1999. Version 2.
Checksum: E130639230FBA58F

FASTA22023,954
        10         20         30         40         50         60 
MHNLEQKTAR IDTLCREARI LPVITIDREA DILPMADALA AGGLTALEIT LRTAHGLTAI 

        70         80         90        100        110        120 
RRLSEERPHL RIGAGTVLDP RTFAAAEKAG ASFVVTPGCT DELLRFALDS EVPLLPGVAS 

       130        140        150        160        170        180 
ASEIMLAYRH GYRRFKLFPA EVSGGPAALK AFSGPFPDIR FCPTGGVSLN NLADYLAVPN 

       190        200        210        220 
VMCVGGTWML PKAVVDRGDW AQVERLSREA LERFAEHRRH 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF029673 Genomic DNA. Translation: AAC38312.2.
AE004091 Genomic DNA. Translation: AAG06569.1.
PIRG83247.
RefSeqNP_251871.1. NC_002516.2.

3D structure databases

ProteinModelPortalO68283.
SMRO68283. Positions 3-211.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING208964.PA3181.

Protocols and materials databases

DNASU882580.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAG06569; AAG06569; PA3181.
GeneID882580.
KEGGpae:PA3181.
PATRIC19840929. VBIPseAer58763_3325.

Organism-specific databases

PseudoCAPPA3181.

Phylogenomic databases

eggNOGCOG0800.
HOGENOMHOG000233114.
KOK01625.
OMADILPMAD.
OrthoDBEOG67DPKT.
PhylomeDBO68283.

Enzyme and pathway databases

BioCycRETL1328306-WGS:GSTH-3709-MONOMER.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR000887. Aldlse_KDPG_KHG.
IPR013785. Aldolase_TIM.
[Graphical view]
PfamPF01081. Aldolase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01182. eda. 1 hit.
PROSITEPS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALKD_PSEAE
AccessionPrimary (citable) accession number: O68283
Secondary accession number(s): Q7DCB2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 1, 1999
Last modified: July 9, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families