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O68283

- ALKD_PSEAE

UniProt

O68283 - ALKD_PSEAE

Protein

2-dehydro-3-deoxy-phosphogluconate aldolase

Gene

eda

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 2 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei52 – 521PROSITE-ProRule annotation
    Active sitei136 – 1361Schiff-base intermediate with substratePROSITE-ProRule annotation

    GO - Molecular functioni

    1. 2-dehydro-3-deoxy-phosphogluconate aldolase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    BioCyciRETL1328306-WGS:GSTH-3709-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-dehydro-3-deoxy-phosphogluconate aldolase (EC:4.1.2.14)
    Alternative name(s):
    KDPG-aldolase
    Phospho-2-dehydro-3-deoxygluconate aldolase
    Phospho-2-keto-3-deoxygluconate aldolase
    Gene namesi
    Name:eda
    Ordered Locus Names:PA3181
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA3181.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2202202-dehydro-3-deoxy-phosphogluconate aldolasePRO_0000287743Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Protein-protein interaction databases

    STRINGi208964.PA3181.

    Structurei

    3D structure databases

    ProteinModelPortaliO68283.
    SMRiO68283. Positions 3-211.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the KHG/KDPG aldolase family.Curated

    Phylogenomic databases

    eggNOGiCOG0800.
    HOGENOMiHOG000233114.
    KOiK01625.
    OMAiDILPMAD.
    OrthoDBiEOG67DPKT.
    PhylomeDBiO68283.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR000887. Aldlse_KDPG_KHG.
    IPR013785. Aldolase_TIM.
    [Graphical view]
    PfamiPF01081. Aldolase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01182. eda. 1 hit.
    PROSITEiPS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
    PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O68283-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHNLEQKTAR IDTLCREARI LPVITIDREA DILPMADALA AGGLTALEIT    50
    LRTAHGLTAI RRLSEERPHL RIGAGTVLDP RTFAAAEKAG ASFVVTPGCT 100
    DELLRFALDS EVPLLPGVAS ASEIMLAYRH GYRRFKLFPA EVSGGPAALK 150
    AFSGPFPDIR FCPTGGVSLN NLADYLAVPN VMCVGGTWML PKAVVDRGDW 200
    AQVERLSREA LERFAEHRRH 220
    Length:220
    Mass (Da):23,954
    Last modified:May 1, 1999 - v2
    Checksum:iE130639230FBA58F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF029673 Genomic DNA. Translation: AAC38312.2.
    AE004091 Genomic DNA. Translation: AAG06569.1.
    PIRiG83247.
    RefSeqiNP_251871.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG06569; AAG06569; PA3181.
    GeneIDi882580.
    KEGGipae:PA3181.
    PATRICi19840929. VBIPseAer58763_3325.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF029673 Genomic DNA. Translation: AAC38312.2 .
    AE004091 Genomic DNA. Translation: AAG06569.1 .
    PIRi G83247.
    RefSeqi NP_251871.1. NC_002516.2.

    3D structure databases

    ProteinModelPortali O68283.
    SMRi O68283. Positions 3-211.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA3181.

    Protocols and materials databases

    DNASUi 882580.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG06569 ; AAG06569 ; PA3181 .
    GeneIDi 882580.
    KEGGi pae:PA3181.
    PATRICi 19840929. VBIPseAer58763_3325.

    Organism-specific databases

    PseudoCAPi PA3181.

    Phylogenomic databases

    eggNOGi COG0800.
    HOGENOMi HOG000233114.
    KOi K01625.
    OMAi DILPMAD.
    OrthoDBi EOG67DPKT.
    PhylomeDBi O68283.

    Enzyme and pathway databases

    BioCyci RETL1328306-WGS:GSTH-3709-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR000887. Aldlse_KDPG_KHG.
    IPR013785. Aldolase_TIM.
    [Graphical view ]
    Pfami PF01081. Aldolase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01182. eda. 1 hit.
    PROSITEi PS00159. ALDOLASE_KDPG_KHG_1. 1 hit.
    PS00160. ALDOLASE_KDPG_KHG_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "HexR, zwf, and eda genes."
      Hager P.W., Dail M.B., Phibbs P.V. Jr.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

    Entry informationi

    Entry nameiALKD_PSEAE
    AccessioniPrimary (citable) accession number: O68283
    Secondary accession number(s): Q7DCB2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 82 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3