Reviewed, UniProtKB/Swiss-Prot O68282 (G6PD_PSEAE)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate 1-dehydrogenase
      Short name=G6PD
    EC=1.1.1.49

Gene names

Name:	zwf
Ordered Locus Names:	PA3183

Organism

Pseudomonas aeruginosa [Complete proteome] [HAMAP]

Taxonomic identifier

287 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	489 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate + NADP(+) = D-glucono-1,5-lactone 6-phosphate + NADPH.
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
Sequence similarities	Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro glucose-6-phosphate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 489	489	Glucose-6-phosphate 1-dehydrogenase		PRO_0000068131
Sites
	Active site	237	1	Proton acceptor By similarity
	Binding site	17	1	NADP By similarity
	Binding site	49	1	NADP By similarity
	Binding site	175	1	Substrate By similarity
	Binding site	179	1	Substrate By similarity
	Binding site	342	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	O68282-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 755849EB33BF9486	FASTA	489	55,620
	10 20 30 40 50 60 MPDVRVLPCT LALFGALGDL ALRKLFPALY QLDRENLLHR DTRVLALARD EGAPAEHLAT 70 80 90 100 110 120 LEQRLRLAVP AKEWDDVVWQ RFRERLDYLS MDFLDPQAYV GLREAVDDEL PLVAYFATPA 130 140 150 160 170 180 SVFGGICENL AAAGLAERTR VVLEKPIGHD LESSREVNEA VARFFPESRI YRIDHYLGKE 190 200 210 220 230 240 TVQNLIALRF ANSLFETQWN QNHISHVEIT VAEKVGIEGR WGYFDQAGQL RDMVQNHLLQ 250 260 270 280 290 300 LLCLIAMDPP SDLSADSIRD EKVKVLRALE PIPAEQLASR VVRGQYTAGF SDGKAVPGYL 310 320 330 340 350 360 EEEHANRDSD AETFVALRVD IRNWRWSGVP FYLRTGKRMP QKLSQIVIHF KEPPHYIFAP 370 380 390 400 410 420 EQRSLISNRL IIRLQPDEGI SLQVMTKDQG LGKGMQLRTG PLQLSFSETY HAARIPDAYE 430 440 450 460 470 480 RLLLEVTQGN QYLFVRKDEV EFAWKWCDQL IAGWERLSEA PKPYPAGSWG PVASVALVAR DGRSWYGDF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of the Pseudomonas aeruginosa zwf gene encoding glucose-6-phosphate dehydrogenase, an enzyme important in resistance to methyl viologen (paraquat)." Ma J.-F., Hager P.W., Howell M.L., Phibbs P.V. Jr., Hassett D.J. J. Bacteriol. 180:1741-1749(1998) [PubMed: 9537370] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
[2]	"Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen." Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P., Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M., Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y., Brody L.L., Coulter S.N., Folger K.R. , Kas A., Larbig K., Lim R.M., Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V. Nature 406:959-964(2000) [PubMed: 10984043] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF029673 Genomic DNA. Translation: AAC38311.1. AE004091 Genomic DNA. Translation: AAG06571.1.
PIR	A83248.
RefSeq	NP_251873.1.
3D structure databases
HSSP	HSSP built from PDB template 1QKI based on UniProtKB P11413.
ModBase	Search...
Genome annotation databases
GeneID	882681.
GenomeReviews	Gene locus PA3183 in contig AE004091_GR.
KEGG	pae:PA3183.
Organism-specific databases
PseudoCAP	PA3183.
CMR	Search...
Phylogenomic databases
HOGENOM	O68282.
Enzyme and pathway databases
BioCyc	PAER208964:PA3183-MON.
Family and domain databases
InterPro	IPR001282. Glc-6-P_DHase. IPR016040. NAD(P)-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR23429. G6PDH. 1 hit.
Pfam	PF02781. G6PD_C. 1 hit. PF00479. G6PD_N. 1 hit. [Graphical view]
PIRSF	PIRSF000110. G6PD. 1 hit.
PRINTS	PR00079. G6PDHDRGNASE.
ProDom	PD001129. G6PD. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00871. zwf. 1 hit.
PROSITE	PS00069. G6P_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PD_PSEAE

Accession

Primary (citable) accession number: O68282

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	August 1, 1998
Last modified:	November 25, 2008
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)