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O68280

- GLMS_NOSS9

UniProt

O68280 - GLMS_NOSS9

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene
glmS, nodM
Organism
Nostoc sp. (strain PCC 9229)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei622 – 6221For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Synonyms:nodM
OrganismiNostoc sp. (strain PCC 9229)
Taxonomic identifieri70817 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 627626Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationPRO_0000135362Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO68280.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 224223Glutamine amidotransferase type-2Add
BLAST
Domaini293 – 442150SIS 1Add
BLAST
Domaini476 – 617142SIS 2Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O68280-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIVGYIGT QAATDILLAG LEKLEYRGYD SAGIATVWEG EINCVRAKGK    50
LHNLRSKLEL IETPAQIGIG HTRWATHGKP EEYNAHPHVD TAMPVAVQNG 100
IIENYRELRE ELKAKGHVFR SETDTEVIPH LIAEILKNFS ASSSSSDFLE 150
AVSQAVNRLE GAFALAVVCA DYPDELIVVR QQAPLVIGFG QGEFFCASDT 200
PAIVAYTRAV LPLENGEIAR LTPLGIEIYN FAGHRLKKQP RLLNLNPTMV 250
VKTGFKHFML KEIHEQPGVV RASLEAYFNN GRGKWRSPIN LRLPENLYTD 300
LEQIHIVACG TSWHAALIGK YLIEQLAGIS TQVHYASEYR YAPSPLTSNT 350
LIIGVTQSGE TADTLAALAM EKERRQGKEA KYEARLLGIT NRPESSLLSH 400
LVPNIISTLA GIEIGVLATK TFTAQLMAFY ALALDLAAHR QTASKETLEK 450
IINGLREIPK DIESTLESQE RLTEQLAHEF AETQDFIFLG RGINFPIALE 500
GALKLKEISY IHAEGYPAGE MKHGPIALLD AKVPVVAIAV PGSVYEKVIS 550
NAQEAKARDS RLIGVTPVKD GEAGEIFNDL LPVSHVEELL SPLLTVVPLQ 600
LLAYHIAARR GLDVDQPRNL AKSVTVE 627
Length:627
Mass (Da):68,770
Last modified:January 23, 2007 - v3
Checksum:i0DCA6B695C177708
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF028734 Genomic DNA. Translation: AAC17973.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF028734 Genomic DNA. Translation: AAC17973.1 .

3D structure databases

ProteinModelPortali O68280.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of a nodM homologous gene in the symbiotic cyanobacterium Nostoc PCC 9229."
    Viterbo A., Matveyev A., Rasmussen U., Bergman B.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGLMS_NOSS9
AccessioniPrimary (citable) accession number: O68280
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 67 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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