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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Nostoc sp. (strain PCC 9229)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei622For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Synonyms:nodM
OrganismiNostoc sp. (strain PCC 9229)
Taxonomic identifieri70817 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

Subcellular locationi

O68280:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001353622 – 627Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST626

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO68280.
SMRiO68280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 224Glutamine amidotransferase type-2UniRule annotationAdd BLAST223
Domaini293 – 442SIS 1UniRule annotationAdd BLAST150
Domaini476 – 617SIS 2UniRule annotationAdd BLAST142

Keywords - Domaini

Glutamine amidotransferase, Repeat

Family and domain databases

CDDicd05008. SIS_GlmS_GlmD_1. 1 hit.
cd05009. SIS_GlmS_GlmD_2. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiView protein in InterPro
IPR017932. GATase_2_dom.
IPR035466. GlmS/AgaS_SIS.
IPR035490. GlmS/FrlB_SIS.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiView protein in Pfam
PF01380. SIS. 2 hits.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiView protein in PROSITE
PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O68280-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGYIGT QAATDILLAG LEKLEYRGYD SAGIATVWEG EINCVRAKGK
60 70 80 90 100
LHNLRSKLEL IETPAQIGIG HTRWATHGKP EEYNAHPHVD TAMPVAVQNG
110 120 130 140 150
IIENYRELRE ELKAKGHVFR SETDTEVIPH LIAEILKNFS ASSSSSDFLE
160 170 180 190 200
AVSQAVNRLE GAFALAVVCA DYPDELIVVR QQAPLVIGFG QGEFFCASDT
210 220 230 240 250
PAIVAYTRAV LPLENGEIAR LTPLGIEIYN FAGHRLKKQP RLLNLNPTMV
260 270 280 290 300
VKTGFKHFML KEIHEQPGVV RASLEAYFNN GRGKWRSPIN LRLPENLYTD
310 320 330 340 350
LEQIHIVACG TSWHAALIGK YLIEQLAGIS TQVHYASEYR YAPSPLTSNT
360 370 380 390 400
LIIGVTQSGE TADTLAALAM EKERRQGKEA KYEARLLGIT NRPESSLLSH
410 420 430 440 450
LVPNIISTLA GIEIGVLATK TFTAQLMAFY ALALDLAAHR QTASKETLEK
460 470 480 490 500
IINGLREIPK DIESTLESQE RLTEQLAHEF AETQDFIFLG RGINFPIALE
510 520 530 540 550
GALKLKEISY IHAEGYPAGE MKHGPIALLD AKVPVVAIAV PGSVYEKVIS
560 570 580 590 600
NAQEAKARDS RLIGVTPVKD GEAGEIFNDL LPVSHVEELL SPLLTVVPLQ
610 620
LLAYHIAARR GLDVDQPRNL AKSVTVE
Length:627
Mass (Da):68,770
Last modified:January 23, 2007 - v3
Checksum:i0DCA6B695C177708
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF028734 Genomic DNA. Translation: AAC17973.1.

Similar proteinsi

Entry informationi

Entry nameiGLMS_NOSS9
AccessioniPrimary (citable) accession number: O68280
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 77 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program