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O68280

- GLMS_NOSS9

UniProt

O68280 - GLMS_NOSS9

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Nostoc sp. (strain PCC 9229)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei622 – 6221For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Synonyms:nodM
    OrganismiNostoc sp. (strain PCC 9229)
    Taxonomic identifieri70817 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 627626Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135362Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliO68280.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 224223Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini293 – 442150SIS 1UniRule annotationAdd
    BLAST
    Domaini476 – 617142SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O68280-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCGIVGYIGT QAATDILLAG LEKLEYRGYD SAGIATVWEG EINCVRAKGK    50
    LHNLRSKLEL IETPAQIGIG HTRWATHGKP EEYNAHPHVD TAMPVAVQNG 100
    IIENYRELRE ELKAKGHVFR SETDTEVIPH LIAEILKNFS ASSSSSDFLE 150
    AVSQAVNRLE GAFALAVVCA DYPDELIVVR QQAPLVIGFG QGEFFCASDT 200
    PAIVAYTRAV LPLENGEIAR LTPLGIEIYN FAGHRLKKQP RLLNLNPTMV 250
    VKTGFKHFML KEIHEQPGVV RASLEAYFNN GRGKWRSPIN LRLPENLYTD 300
    LEQIHIVACG TSWHAALIGK YLIEQLAGIS TQVHYASEYR YAPSPLTSNT 350
    LIIGVTQSGE TADTLAALAM EKERRQGKEA KYEARLLGIT NRPESSLLSH 400
    LVPNIISTLA GIEIGVLATK TFTAQLMAFY ALALDLAAHR QTASKETLEK 450
    IINGLREIPK DIESTLESQE RLTEQLAHEF AETQDFIFLG RGINFPIALE 500
    GALKLKEISY IHAEGYPAGE MKHGPIALLD AKVPVVAIAV PGSVYEKVIS 550
    NAQEAKARDS RLIGVTPVKD GEAGEIFNDL LPVSHVEELL SPLLTVVPLQ 600
    LLAYHIAARR GLDVDQPRNL AKSVTVE 627
    Length:627
    Mass (Da):68,770
    Last modified:January 23, 2007 - v3
    Checksum:i0DCA6B695C177708
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF028734 Genomic DNA. Translation: AAC17973.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF028734 Genomic DNA. Translation: AAC17973.1 .

    3D structure databases

    ProteinModelPortali O68280.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a nodM homologous gene in the symbiotic cyanobacterium Nostoc PCC 9229."
      Viterbo A., Matveyev A., Rasmussen U., Bergman B.
      Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiGLMS_NOSS9
    AccessioniPrimary (citable) accession number: O68280
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 68 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3