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O68186

- PUR5_LACLM

UniProt

O68186 - PUR5_LACLM

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Lactococcus lactis subsp. cremoris (strain MG1363)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLLAC416870:GCDT-1012-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:llmg_0987
OrganismiLactococcus lactis subsp. cremoris (strain MG1363)
Taxonomic identifieri416870 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000000364: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000148217Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi416870.llmg_0987.

Structurei

3D structure databases

ProteinModelPortaliO68186.
SMRiO68186. Positions 16-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiEFEMYRT.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

O68186 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVSENAYAK SGVDVEAGYE VVSRIKKHVA KTERLGVLGA LGGFGGSFDL
60 70 80 90 100
SVLDVKEPVL ISGTDGVGTK LMLAIRADKH DTIGIDCVAM CVNDIIAAGA
110 120 130 140 150
EPLYFLDYIA TGKNIPEKLE QVVAGVAEGC LQAGAALIGG ETAEMPGMYD
160 170 180 190 200
EDDYDLAGFA VGVAEKSQLI DGEKDVEAGD VLLGLASSGI HSNGYSLVRK
210 220 230 240 250
VFADFDLNES LPELDQSLID TLLTPTKIYV KELLPLIKQN KIKGIAHITG
260 270 280 290 300
GGFHENLPRM FGNSLSAEIV EGSWDVLPIF KALEKYGSIK HEEMYEIFNM
310 320 330 340
GIGMVIAVAP ENAAALKKEL NAFEIGQMVN RQEAPVVIKK
Length:340
Mass (Da):36,292
Last modified:August 1, 1998 - v1
Checksum:iE220C4C8780CBBE0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016634 Genomic DNA. Translation: AAC16901.1.
AM406671 Genomic DNA. Translation: CAL97580.1.
RefSeqiWP_011834923.1. NC_009004.1.
YP_001032308.1. NC_009004.1.

Genome annotation databases

EnsemblBacteriaiCAL97580; CAL97580; llmg_0987.
GeneIDi4797128.
KEGGillm:llmg_0987.
PATRICi22283100. VBILacLac4574_1008.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF016634 Genomic DNA. Translation: AAC16901.1 .
AM406671 Genomic DNA. Translation: CAL97580.1 .
RefSeqi WP_011834923.1. NC_009004.1.
YP_001032308.1. NC_009004.1.

3D structure databases

ProteinModelPortali O68186.
SMRi O68186. Positions 16-313.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 416870.llmg_0987.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL97580 ; CAL97580 ; llmg_0987 .
GeneIDi 4797128.
KEGGi llm:llmg_0987.
PATRICi 22283100. VBILacLac4574_1008.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi EFEMYRT.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci LLAC416870:GCDT-1012-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Chaperones and ATP-dependent proteases of Lactococcus lactis."
    Coward C.
    Thesis (1998), University of Cambridge, United Kingdom
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete genome sequence of the lactic acid bacterial paradigm Lactococcus lactis subsp. cremoris MG1363."
    Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C., Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P., van Sinderen D., Kok J.
    J. Bacteriol. 189:3256-3270(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MG1363.

Entry informationi

Entry nameiPUR5_LACLM
AccessioniPrimary (citable) accession number: O68186
Secondary accession number(s): A2RJX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: August 1, 1998
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3