ID   COBK_RHOCA              Reviewed;         251 AA.
AC   O68098;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Precorrin-6A reductase;
DE            EC=1.3.1.54;
DE   AltName: Full=Precorrin-6X reductase;
GN   Name=cobK;
OS   Rhodobacter capsulatus (Rhodopseudomonas capsulata).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Rhodobacter.
OX   NCBI_TaxID=1061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 23782 / LMG 2373 / NCIB 11773 / SB1003 / St. Louis;
RX   MEDLINE=97404404; PubMed=9256491;
RA   Vlcek C., Paces V., Maltsev N., Paces J., Haselkorn R., Fonstein M.;
RT   "Sequence of a 189-kb segment of the chromosome of Rhodobacter
RT   capsulatus SB1003.";
RL   Proc. Natl. Acad. Sci. U.S.A. 94:9384-9388(1997).
CC   -!- FUNCTION: Catalyzes the reduction of the macrocycle of precorrin-
CC       6X into precorrin-6Y.
CC   -!- CATALYTIC ACTIVITY: Precorrin-6B + NADP(+) = precorrin-6A + NADPH.
CC   -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis;
CC       cob(II)yrinic acid a,c-diamide from precorrin-2 (aerobic route):
CC       step 6/10.
CC   -!- SIMILARITY: Belongs to the precorrin-6x reductase family.
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DR   EMBL; AF010496; AAC16188.1; -; Genomic_DNA.
DR   PIR; T03535; T03535.
DR   BRENDA; 1.3.1.54; 567.
DR   GO; GO:0016994; F:precorrin-6A reductase activity; IEA:EC.
DR   GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR003723; Cbl_synth_CobK/CbiJ.
DR   Pfam; PF02571; CbiJ; 1.
DR   TIGRFAMs; TIGR00715; precor6x_red; 1.
DR   PROSITE; PS51014; COBK_CBIJ; 1.
PE   3: Inferred from homology;
KW   Cobalamin biosynthesis; NADP; Oxidoreductase.
FT   CHAIN         1    251       Precorrin-6A reductase.
FT                                /FTId=PRO_0000135921.
SQ   SEQUENCE   251 AA;  26048 MW;  877B825031DB202F CRC64;
     MTRLLVLGGT TEASRLAKTL ADQGFEAVFS YAGRTGAPVA QPLPTRIGGF GGVAGLVDYL
     TREGVSHVID ATHPFAAQMS ANAVAACAQT GVALCAFERA PWTAQAGDRW THVPDLAAAV
     AALPQAPARV FLAIGKQHLR DFSAAPQHHY LLRLVDPPEG PLPLPDARAV IARGPFTVQG
     DTELLRSETI THVVAKNAGG AGAEAKLIAA RSLGLPVILI DRPAVPARDI CATLEGVMGW
     LADHGATPRG V
//