Reviewed, UniProtKB/Swiss-Prot O68098 (COBK_RHOCA)

Names and origin

Protein names

Recommended name:
    Precorrin-6A reductase
    EC=1.3.1.54
Alternative name(s):
    Precorrin-6X reductase

Gene names

Name:

cobK

Organism

Rhodobacter capsulatus (Rhodopseudomonas capsulata)

Taxonomic identifier

1061 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y.
Catalytic activity	Precorrin-6B + NADP(+) = precorrin-6A + NADPH.
Pathway	Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinic acid a,c-diamide from precorrin-2 (aerobic route): step 6/10.
Sequence similarities	Belongs to the precorrin-6x reductase family.

Ontologies

Keywords
Biological process	Cobalamin biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cobalamin biosynthetic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	precorrin-6A reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 251	251	Precorrin-6A reductase		PRO_0000135921

Sequences

	Sequence		Length	Mass (Da)
	O68098-1 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 877B825031DB202F	FASTA	251	26,048
	10 20 30 40 50 60 MTRLLVLGGT TEASRLAKTL ADQGFEAVFS YAGRTGAPVA QPLPTRIGGF GGVAGLVDYL 70 80 90 100 110 120 TREGVSHVID ATHPFAAQMS ANAVAACAQT GVALCAFERA PWTAQAGDRW THVPDLAAAV 130 140 150 160 170 180 AALPQAPARV FLAIGKQHLR DFSAAPQHHY LLRLVDPPEG PLPLPDARAV IARGPFTVQG 190 200 210 220 230 240 DTELLRSETI THVVAKNAGG AGAEAKLIAA RSLGLPVILI DRPAVPARDI CATLEGVMGW 250 LADHGATPRG V

References

[1]

"Sequence of a 189-kb segment of the chromosome of Rhodobacter capsulatus SB1003." Vlcek C., Paces V., Maltsev N., Paces J., Haselkorn R., Fonstein M. Proc. Natl. Acad. Sci. U.S.A. 94:9384-9388(1997) [PubMed: 9256491] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 23782 / LMG 2373 / NCIB 11773 / SB1003 / St. Louis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF010496 Genomic DNA. Translation: AAC16188.1.
PIR	T03535.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR003723. Cbl_synth_CobK/CbiJ. [Graphical view]
Pfam	PF02571. CbiJ. 1 hit. [Graphical view]
TIGRFAMs	TIGR00715. precor6x_red. 1 hit.
PROSITE	PS51014. COBK_CBIJ. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COBK_RHOCA

Accession

Primary (citable) accession number: O68098

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	August 1, 1998
Last modified:	November 25, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)