O68098 (COBK_RHOCB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Precorrin-6A reductase
EC=1.3.1.54

Alternative name(s):
Precorrin-6X reductase

Gene names

Name:	cobK
Ordered Locus Names:	RCAP_rcc02043

Organism

Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) [Complete proteome] [HAMAP]

Taxonomic identifier

272942 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length	251 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y.
Catalytic activity	Precorrin-6B + NADP+ = precorrin-6A + NADPH.
Pathway	Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from precorrin-2 (aerobic route): step 6/10.
Sequence similarities	Belongs to the precorrin-6x reductase family.

Ontologies

Keywords
Biological process	Cobalamin biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cobalamin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	precorrin-6A reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 251	251	Precorrin-6A reductase		PRO_0000135921

Sequences

	Sequence		Length	Mass (Da)
	O68098 [UniParc]. Last modified August 1, 1998. Version 1. Checksum: 877B825031DB202F	FASTA	251	26,048
	10 20 30 40 50 60 MTRLLVLGGT TEASRLAKTL ADQGFEAVFS YAGRTGAPVA QPLPTRIGGF GGVAGLVDYL 70 80 90 100 110 120 TREGVSHVID ATHPFAAQMS ANAVAACAQT GVALCAFERA PWTAQAGDRW THVPDLAAAV 130 140 150 160 170 180 AALPQAPARV FLAIGKQHLR DFSAAPQHHY LLRLVDPPEG PLPLPDARAV IARGPFTVQG 190 200 210 220 230 240 DTELLRSETI THVVAKNAGG AGAEAKLIAA RSLGLPVILI DRPAVPARDI CATLEGVMGW 250 LADHGATPRG V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of a 189-kb segment of the chromosome of Rhodobacter capsulatus SB1003." Vlcek C., Paces V., Maltsev N., Paces J., Haselkorn R., Fonstein M. Proc. Natl. Acad. Sci. U.S.A. 94:9384-9388(1997) [PubMed: 9256491] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC BAA-309 / NBRC 16581 / SB1003.
[2]	"Complete genome sequence of the photosynthetic purple nonsulfur bacterium Rhodobacter capsulatus SB 1003." Strnad H., Lapidus A., Paces J., Ulbrich P., Vlcek C., Paces V., Haselkorn R. J. Bacteriol. 192:3545-3546(2010) [PubMed: 20418398] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-309 / NBRC 16581 / SB1003.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF010496 Genomic DNA. Translation: AAC16188.1. CP001312 Genomic DNA. Translation: ADE85787.1.
PIR	T03535.
RefSeq	YP_003578194.1. NC_014034.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	9004866.
GenomeReviews	Gene locus RCAP_rcc02043 in contig CP001312_GR.
KEGG	rcp:RCAP_rcc02043.
PATRIC	35504248. VBIRhoCap134200_2077.
Organism-specific databases
CMR	Search...
Phylogenomic databases
ProtClustDB	PRK08057.
Family and domain databases
InterPro	IPR003723. Cbl_synth_CobK/CbiJ. [Graphical view]
KO	K05895.
Pfam	PF02571. CbiJ. 1 hit. [Graphical view]
TIGRFAMs	TIGR00715. Precor6x_red. 1 hit.
PROSITE	PS51014. COBK_CBIJ. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COBK_RHOCB

Accession

Primary (citable) accession number: O68098
Secondary accession number(s): D5AV05

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	August 1, 1998
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program