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Protein

DNA topoisomerase 4 subunit B

Gene

parE

Organism
Rhodobacter capsulatus (Rhodopseudomonas capsulata)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.UniRule annotation

Catalytic activityi

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotationSAAS annotation

Cofactori

Mg2+SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14ATPUniRule annotation1
Binding sitei54ATPUniRule annotation1
Binding sitei81ATPUniRule annotation1
Binding sitei353ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi123 – 129ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, Isomerase, TopoisomeraseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomerase 4 subunit BUniRule annotation (EC:5.99.1.3UniRule annotation)
Alternative name(s):
Topoisomerase IV subunit BUniRule annotation
Gene namesi
Name:parEUniRule annotation
OrganismiRhodobacter capsulatus (Rhodopseudomonas capsulata)Imported
Taxonomic identifieri1061 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Subcellular locationi

GO - Cellular componenti

Interactioni

Subunit structurei

Heterotetramer composed of ParC and ParE.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei467Interaction with DNAUniRule annotation1
Sitei519Interaction with DNAUniRule annotation1
Sitei636Interaction with DNAUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliO68071.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini433 – 547ToprimInterPro annotationAdd BLAST115

Sequence similaritiesi

Belongs to the type II topoisomerase family. ParE type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C7D. Bacteria.
COG0187. LUCA.
HOGENOMiHOG000075154.

Family and domain databases

CDDicd00075. HATPase_c. 1 hit.
Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
3.40.50.670. 1 hit.
HAMAPiMF_00938. ParE_type1. 1 hit.
InterProiView protein in InterPro
IPR002288. DNA_gyrase_B_C.
IPR003594. HATPase_C.
IPR036890. HATPase_C_sf.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR001241. Topo_IIA.
IPR013760. Topo_IIA-like_dom_sf.
IPR013759. Topo_IIA_B_C.
IPR013506. Topo_IIA_bsu_dom2.
IPR018522. TopoIIA_CS.
IPR005737. TopoIV_B_Gneg.
IPR006171. TOPRIM_domain.
PANTHERiPTHR10169. PTHR10169. 1 hit.
PfamiView protein in Pfam
PF00204. DNA_gyraseB. 1 hit.
PF00986. DNA_gyraseB_C. 1 hit.
PF02518. HATPase_c. 1 hit.
PF01751. Toprim. 1 hit.
SMARTiView protein in SMART
SM00387. HATPase_c. 1 hit.
SM00433. TOP2c. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
SSF56719. SSF56719. 1 hit.
TIGRFAMsiTIGR01055. parE_Gneg. 1 hit.
PROSITEiView protein in PROSITE
PS00177. TOPOISOMERASE_II. 1 hit.
PS50880. TOPRIM. 1 hit.

Sequencei

Sequence statusi: Complete.

O68071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGDLLSSTP SETYDASSIE VLEGLEPVRK RPGMYIGGTD ERALHHMVAE
60 70 80 90 100
ILDNAMDEAV AGHANRIEVE VNADGSVTVR DNGRGIPVDP HPKFPGKSAL
110 120 130 140 150
EVILCTLHAG GKFSNKAYST SGGLNGVGSS VVNALSDLMV VQVARNKELY
160 170 180 190 200
EQRFSRGVPQ GPVAKLGAAP NRRGTTVTFH PDPEIFGSLS LKPARLFKMT
210 220 230 240 250
RSKAYLFSGV EIRWKTAIAD GDTPTEATFH FPNGLADYLA EALTGASTYS
260 270 280 290 300
DKPFAGRVSF EEKYNIPGSV EWAINWTPVR DGFIHSYCNT VPTPEGGTHE
310 320 330 340 350
AGFWAAILKG IRAYGERINN KKAAQITRED MLTGGCALIS IFIREPSFVG
360 370 380 390 400
QTKDRLSTEE AARWVENAVR DYFDTWLTTD TKAAGAILDF LVLRAEERLR
410 420 430 440 450
RKAEKETSRK SATKKLRLPG KLVDCSATNR EGTELFIVEG DSAGGSAKMA
460 470 480 490 500
RDRTMQALLP LRGKILNVLG AASSKLGQNQ EINDLAQALG VGLGTKFRVD
510 520 530 540 550
DLRYDKIIIM TDADVDGAHI ASLLMTFFFT QMRGLIDKGH LYLACPPLYR
560 570 580 590 600
LTQGAKRIYV ADDAEKDVWM AKGLGGRGKI DVQRFKGLGE MDAKDLKDTT
610 620 630 640 650
MNPATRKLIR VTIDDEFAGE TDDLVERLMG KKPELRFQYI TENARFVEEL

DV
Length:652
Mass (Da):71,524
Last modified:August 1, 1998 - v1
Checksum:i4CE2687B47F4289D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF010496 Genomic DNA. Translation: AAC16157.1.
PIRiT03504.

Genome annotation databases

GeneIDi31490940.

Similar proteinsi

Entry informationi

Entry nameiO68071_RHOCA
AccessioniPrimary (citable) accession number: O68071
Entry historyiIntegrated into UniProtKB/TrEMBL: August 1, 1998
Last sequence update: August 1, 1998
Last modified: November 22, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)