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Protein

Bacitracin synthase 3

Gene

bacC

Organism
Bacillus licheniformis
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Induces peptide synthesis, activates and incorporates five amino acids, forms a thiazoline ring between the first two amino acids and incoporates a D-glutamine in the fourth position.

Catalytic activityi

L-aspartate = D-aspartate.
ATP + L-phenylalanine + H2O = AMP + diphosphate + D-phenylalanine.

Cofactori

pantetheine 4'-phosphateCuratedNote: Binds 5 phosphopantetheines covalently.Curated

Pathwayi: bacitracin biosynthesis

This protein is involved in the pathway bacitracin biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway bacitracin biosynthesis and in Antibiotic biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Isomerase, Ligase

Keywords - Biological processi

Antibiotic biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00179.

Protein family/group databases

ESTHERibacli-bacc. Thioesterase.

Names & Taxonomyi

Protein namesi
Recommended name:
Bacitracin synthase 3
Short name:
BA3
Including the following 7 domains:
ATP-dependent isoleucine adenylase
Short name:
IleA
Alternative name(s):
Isoleucine activase
ATP-dependent D-phenylalanine adenylase
Short name:
D-PheA
Alternative name(s):
D-phenylalanine activase
ATP-dependent histidine adenylase
Short name:
HisA
Alternative name(s):
Histidine activase
ATP-dependent D-aspartate adenylase
Short name:
D-AspA
Alternative name(s):
D-aspartate activase
ATP-dependent asparagine adenylase
Short name:
AsnA
Alternative name(s):
Asparagine activase
Aspartate racemase (EC:5.1.1.13)
Phenylalanine racemase [ATP hydrolyzing] (EC:5.1.1.11)
Gene namesi
Name:bacC
OrganismiBacillus licheniformis
Taxonomic identifieri1402 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 63596359Bacitracin synthase 3PRO_0000193084Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei996 – 9961O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation
Modified residuei2028 – 20281O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation
Modified residuei3532 – 35321O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation
Modified residuei4574 – 45741O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation
Modified residuei6082 – 60821O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Interactioni

Subunit structurei

Large multienzyme complex of BA1, BA2 and BA3.

Structurei

3D structure databases

ProteinModelPortaliO68008.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini966 – 103368Acyl carrier 1PROSITE-ProRule annotationAdd
BLAST
Domaini1998 – 206467Acyl carrier 2PROSITE-ProRule annotationAdd
BLAST
Domaini3502 – 356968Acyl carrier 3PROSITE-ProRule annotationAdd
BLAST
Domaini4544 – 461067Acyl carrier 4PROSITE-ProRule annotationAdd
BLAST
Domaini6052 – 611968Acyl carrier 5PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni461 – 1034574Domain 1 (isoleucine-activating)Add
BLAST
Regioni1517 – 2064548Domain 2 (D-phenylalanine-activating)Add
BLAST
Regioni2999 – 3570572Domain 3 (histidine-activating)Add
BLAST
Regioni4047 – 4612566Domain 4 (D-aspartic acid-activating)Add
BLAST
Regioni5549 – 6129581Domain 5 (asparagine-activating)Add
BLAST

Domaini

Consists of five modules with two epimerization domains in the second and fourth modules, and a putative C-terminal thioesterase domain. Each module incorporates one amino acid into the peptide product and can be further subdivided into domains responsible for substrate adenylation, thiolation, condensation (not for the initiation module), and epimerization (optional), and N methylation (optional).

Sequence similaritiesi

Contains 5 acyl carrier domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.1200.10. 5 hits.
3.40.50.1820. 2 hits.
InterProiIPR010071. AA_adenyl_domain.
IPR029058. AB_hydrolase.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR001242. Condensatn.
IPR010060. NRPS_synth.
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
IPR001031. Thioesterase.
[Graphical view]
PfamiPF00501. AMP-binding. 5 hits.
PF13193. AMP-binding_C. 5 hits.
PF00668. Condensation. 7 hits.
PF00550. PP-binding. 5 hits.
PF00975. Thioesterase. 1 hit.
[Graphical view]
SMARTiSM00823. PKS_PP. 5 hits.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 5 hits.
SSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01733. AA-adenyl-dom. 5 hits.
TIGR01720. NRPS-para261. 2 hits.
PROSITEiPS50075. ACP_DOMAIN. 5 hits.
PS00455. AMP_BINDING. 5 hits.
PS00012. PHOSPHOPANTETHEINE. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O68008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTKVEKIYP LSNMQKGMLF HAMKDEASHA YFEQFIIELK GDVDERMFEE
60 70 80 90 100
SLNEVMKRHE ILRASFHHRL DEPLHVIIKD RHMKFDYLDI RGRHDQDGVL
110 120 130 140 150
ERYLAEDRQK GFDLAKDTLM RACLIRMSDD SYQFVWTYHH ILLDGWCLGI
160 170 180 190 200
ILDELLTIYE MKRKGQNHQL EDPRPYSDYI KWLEDQDKEE AQSYWESYLS
210 220 230 240 250
GYDQKNSLPK LRTPSETGFK RREKTIECSK ELTNRLIKLA NRNHVTINTV
260 270 280 290 300
LQSIWGVILA KYNNSEDVVF GTVVSGRDAE VEGIETMVGV FINTIPTRIR
310 320 330 340 350
LDKDKLFKDV LRQTQADALE SSRYNYMNLA EVQALSELKN DLIDHVMVFE
360 370 380 390 400
NYAVDQKAFE EKNDVGFEMV NVSGEEQTNY HFSISAALDD QLKLLFIYDE
410 420 430 440 450
NVYDTTIIET LEKHIITVAE QVAEDETQTL RDINLVSKEE QHRILDTFND
460 470 480 490 500
TKTGYPKDKP LHELFEEQAM KTPDHTALVF GAQRMTYREL NEKANQTARL
510 520 530 540 550
LREKGIGRGS IAAIIADRSF EMIIGIIGIL KAGGAYLPID PETPKHRIAF
560 570 580 590 600
MLSDTKAGVL LAQGKAADGI DCEADIIHLD KGVADGFSKK RLSSVNDSGD
610 620 630 640 650
TAYIIYTSGS TGMPKGVVTP HYSAARVVKN TNYIDITEDD AILQLSNYSF
660 670 680 690 700
DGSVFDIFGA LLNGASLVLI EKETVLNTHE LAEVIKKEQV SVMFITTALF
710 720 730 740 750
NTLADINIGC LAKLRKIFLG GERASIPHVR KVLNHVGRDK LIHVYGPTES
760 770 780 790 800
TVYATYYFIN EIDDEAETIP IGSPLANTSV LIMDEAGKLL PIGVPGELCI
810 820 830 840 850
AGDGLSKGYL NREELTAEKF IPHPFIPGER LYKTGDLAKW LPDGNIEFIG
860 870 880 890 900
RIDHQVKIRG FRIELGEIES RLEMHEDINE TIVTVREDEE SRPYICAYIT
910 920 930 940 950
ANREISLDEL KGFLGEKLPE YMIPAYFVKM DKLPLTKNGK VDRKALPEPD
960 970 980 990 1000
RTAGAENEYE APRNETEEKL AAIWRDILKV EKSGINDHFF EMGGHSLKAA
1010 1020 1030 1040 1050
AMAARIRKEL KAEIPLGQIF KTPTIKGLGE YIRSTKDSVY SSIQKVEEKE
1060 1070 1080 1090 1100
YYRLSSAQKR LYILDQIEGS GLSYNIPFTM KVKGRFDIRR FENALKTIIQ
1110 1120 1130 1140 1150
RHEALRTSFL MADGEPVQKI EKEVDFSIKC SKIQSLSIQE IIKQFVRPFD
1160 1170 1180 1190 1200
LKKAPLFRTE VVKVDDEEHI ILFDMHHIIS DGASMGVLTK EICDLYGGKE
1210 1220 1230 1240 1250
LKPLSLQYKD YSEWQRDFYQ KDEMKRQKEY WLNIFKGEIP VLNMPTDYPR
1260 1270 1280 1290 1300
PQMHSVEGDR IGFAIDGELT KKLKRIAKDN GATMYMLLLA AYTVLLRTYS
1310 1320 1330 1340 1350
GQEDVIIGTP IQGRKHHELK HVIGMFVNTL AMRNHPKGDK TFAEYLQDVK
1360 1370 1380 1390 1400
ETALKAYENQ DYQFDDLVEQ LDLERDMSRN PLFDTMFVLQ NLEKADAEIE
1410 1420 1430 1440 1450
GLTFEPFESD IHISKFDLTL SAIEKDSKIE FDLEYCTKLF KRETVERMAA
1460 1470 1480 1490 1500
HFVRVLEDIS KRTDKRLDQI EAMSEDEKNT LLYRFNDTKT DAPTDKTICQ
1510 1520 1530 1540 1550
LFAERAETSP DKTAVVFEDQ TLTYRQLHER SNQLARFLRE KGVQPDTAVG
1560 1570 1580 1590 1600
IMVDRSPEMI IGLLGILKAG GAYLPLDPAY PEDRIKYILG DSQTKFLLSE
1610 1620 1630 1640 1650
EALIKKRAFI KEADMINIDI HDKQIAAQDA AQLEPVSRSG DLAYIIYTSG
1660 1670 1680 1690 1700
STGKPKGVLI EQKGLSNLVS AVVKLMHLNT GSRVIQFASL SFDASAFEIF
1710 1720 1730 1740 1750
PALAAGSALV LGRQEEMMPG QPLTSFLRQY NITHATLPPT VLDVLNESGL
1760 1770 1780 1790 1800
ENLKVIVSAG SACSEELAKR WSGNRLFINA YGPTETTVCA TAGIYEGSGR
1810 1820 1830 1840 1850
PHIGSPIANT NVYVLDQNQK PVPTGVVGEL CVGGMSLARG YLNRPELTAE
1860 1870 1880 1890 1900
KFISHPFASG ERLYRTGDLA RWLPDGHLEF LGRIDHQVKI RGYRIELGEI
1910 1920 1930 1940 1950
ENQLLKLDKI DEAAVIARKD DDHSDYLCAY IVSKEDWTST EISEWLEKEL
1960 1970 1980 1990 2000
PHYMIPAYFV RLDKLPLTSN DKVDRKALPA PDRHVATGAV YEAPRNDTEA
2010 2020 2030 2040 2050
KLVDIWRDVL GAGDIGISHH FFAAGGDSIK ALQIVSRLSR LGLKLEMKDL
2060 2070 2080 2090 2100
FANPRIKDLA KYVKKQSQRK NANTIVTGHA ELTPIQKWYF ANNKEELDHF
2110 2120 2130 2140 2150
NQSFVLFRKG GFDESCVKKA FNKIMEQHDA LRMIYEEKGG DFIQYNRSFR
2160 2170 2180 2190 2200
EDLFDLDVYD VRGLDRQAEK VYELATSIQK LSSIRKGKLV HLGIFRADEG
2210 2220 2230 2240 2250
DHLLIVIHHL VVDGVSWRIL FEDFETLYSQ ALKGQTLEIG YKTDSYQEFA
2260 2270 2280 2290 2300
RRLKAYAHSR TLSKEAEYWR NIAKARVRFI PPKNVLKEDV YENSTTLSIK
2310 2320 2330 2340 2350
LGKEATADLL RNTNRAYNTE INDILLTALL TGARDITGEN KLKVMMEGHG
2360 2370 2380 2390 2400
REDILEGVDI TRTIGWFTTM YPVLLDAGEE KALSQQIKMV KETLRKIPNK
2410 2420 2430 2440 2450
GIGYGLLKYM AEDPDFTNEE KARISFNYLG DIDADMNRGE FSGSSFSEGE
2460 2470 2480 2490 2500
SIGGKIARSH SIEINAIVMN HELVIHTTFN QMEYEKDTIS RLNHQLKERL
2510 2520 2530 2540 2550
EQIIKHCTQQ TESERTPSDY GDTNISLAEL EEIKGKYRSA IEKIYPLANM
2560 2570 2580 2590 2600
QKGMLFHAIE DHTSDAYFQQ TVMDIEGYVD PAILEASFND IMKRHEILRA
2610 2620 2630 2640 2650
SYEYEIVEEP RQIIIENRSI DFTYFNIAKS SAQQQEMFIE RLLNEDRKKG
2660 2670 2680 2690 2700
FDLSKDVLMR AYLLKTAERS YRLVWSHHHI LLDGWCLGII MRELFVIYEN
2710 2720 2730 2740 2750
RMNGKASPLK ETKPYSDYIK WLERQDQEEA RQYWREYLKG YEEQAQLPTL
2760 2770 2780 2790 2800
TKRKKSSRYD RREKVIHLSK QLTKQLKELA AKNSVTLHTV IQTIWGLMLT
2810 2820 2830 2840 2850
RYTKIDDVVF GTVVSGREAN VDGIEDMIGL FINTIPTRIR FNEQARFNDC
2860 2870 2880 2890 2900
LQKVQEDAIQ SNRYNYMNLA EVQALSSLKK DLIDHILVFE NYEADEQDFE
2910 2920 2930 2940 2950
ESQMKTGFKV NEISAAEQSI TAFSMSVTPG EELTLVLTYD GNVYDRDIIN
2960 2970 2980 2990 3000
NIEGHIKRVA EQVTANENRK IAEIDMLAEE ERKTLLYEFN RTNADYPRNK
3010 3020 3030 3040 3050
TIHQLFEEQA ERTPGHTAVV FEKEELSYKA LNERSNQLAG LLREKGVKPD
3060 3070 3080 3090 3100
MIVGVMAERS VEMIVGMLAV LKAGGAYLPI DPEYPEDRIR YMIEDSGISI
3110 3120 3130 3140 3150
LLKKADKQID VDFTCIDMNE KGLAKDMAAE NLGHTSGSSD MAYVIYTSGS
3160 3170 3180 3190 3200
TGKPKGVMVN HQSIVNTLYW RKQSYGYSTA DATLQVPSFS FDSSVEDIFT
3210 3220 3230 3240 3250
TLISGAKLVL IRDLRMNPRE IIGVLRTHKA TNLLAVPSFY LNLLDTIEQP
3260 3270 3280 3290 3300
LDDLRFVTVA GEGFNESLIR QHFEKLPNVK LFNEYGPTEN SVCSTRGELR
3310 3320 3330 3340 3350
KDDEKVVIGR PISNHKVYIL NHNQQLLPLG TPGELCLSGE GLARGYLNRP
3360 3370 3380 3390 3400
DLTLEKFVPN PFAPGESMYR TGDLARFLPD GQIEYLGRID HQVKIRGFRI
3410 3420 3430 3440 3450
ELGEIENQLL KIEGIDAAAV MAREDQAGGK YLCAYIVADK AAGVADVRKC
3460 3470 3480 3490 3500
LLKELPDYMV PSYFVKLDQL PLTANGKIDR KALPEPSSTI SEATYEAPRN
3510 3520 3530 3540 3550
RTEEKLVSIW EDVLGIENIG ISHNFFELGG HSLKAAALTA KLHKEMKIEV
3560 3570 3580 3590 3600
PLRQLFETPT IKDIGDFIES MKESPYASIT QAEEKEYYAL SSAQRRLYIL
3610 3620 3630 3640 3650
NQIEPGGLSY NMPFAMKIAG DFDVDRFEDA FRQLIERHEA LRTAFVMVDG
3660 3670 3680 3690 3700
EPVQKIEKEV DFKVKYGRLG QDPLEEKIKA FIKPFALEKA PLLRAEVLKA
3710 3720 3730 3740 3750
SGDEHVLMLD MHHIISDGVS MAIFTRELAE LYEGKTLPPL TIQYKDFSEW
3760 3770 3780 3790 3800
QKLFYQKDEV KRQEDYWLNV FQGEVPVLNL PADEKRPQKR SIEGDIVQFE
3810 3820 3830 3840 3850
IDGETSAMLN KLAKENGATM YMLLLAGYTT LLAKYTGQED IVVGSPIAGR
3860 3870 3880 3890 3900
HHSDLKHVIG LFINTLAMRN HPKGDMPFAD YLKEVKETAL KAYENQDYPF
3910 3920 3930 3940 3950
DELVEKLDVK RDMSRHPLFD TMLVLQNFDG DEADIDGLTF QPLQTEVNIS
3960 3970 3980 3990 4000
KFDLTLTAAE TNEGIQCVFN YSTKLFKRST IERMAGHLIN ILKEAANDPH
4010 4020 4030 4040 4050
MPLSDVNMLS DEEMNALLDQ NQGKQADYPQ DQTVHQLFEQ QADKTPEQTA
4060 4070 4080 4090 4100
VVYADEKLTY RELNERANQL ARLLRDKGAD ADQPVAIMIE PSLEMIISML
4110 4120 4130 4140 4150
AVLKAGAAYV PIEPEQLAKR TNEILSDSRA AILLVKGSVK ENVAFAGEIV
4160 4170 4180 4190 4200
NVADGLIDAK VASNLSASGS ADQNAYIIYT SGSTGKPKGV FVRHGNVVNY
4210 4220 4230 4240 4250
TTWFMKEAGL TENDKAMLVS SYAFDLGYTS IFSALLSGSE LHIARKECYT
4260 4270 4280 4290 4300
NAHRALKYIK ENGITYIKLT PSLFNIFVND PGFSAEKPCA TLRLVVLGGE
4310 4320 4330 4340 4350
MINTRDVETF YNQYPDHVVM NHYGPTETTI GSVFKVIDPE HLDSFKECPV
4360 4370 4380 4390 4400
IGTPIHNTNA YVLDENMKLL PEGVYGELCI AGAGVTGGYV NRPDETKEKF
4410 4420 4430 4440 4450
IENPFAPHTK MYRTGDLARR LSDGNIELAG RIDTQVKVRG YRIEPEEIKN
4460 4470 4480 4490 4500
RLLAHDDIKE AFIAAREDHK GAKQLCAYFT ADAELPFEDI RTYLMHELPE
4510 4520 4530 4540 4550
YMIPSSFVQI EKMPLSANGK IDTAALPEPQ PGKETEYEPP RNETEEKLVQ
4560 4570 4580 4590 4600
IWEEVLGIDK IGITHHFFAA GGDSIKALQM ISRLSREGLS LEMKDLFANP
4610 4620 4630 4640 4650
QIKSLSRYVK AESDKSASYE TVEGEVLLTP IQQEYFSLNK TDRNHYNHAV
4660 4670 4680 4690 4700
MLYRKNGFDE SIVKRVFKEI IKHHDALRTV FTEEDGKIIQ YNRGPDKQLF
4710 4720 4730 4740 4750
DLFVYDVSSE NDQPQKVYQL ATELQQSIDI ETGPLVKLAV FKTNNGDHLL
4760 4770 4780 4790 4800
IIIHHLVVDG ISWRILFEDL AIGYSQLANG EKVEFYPKTA SYQAYARHIA
4810 4820 4830 4840 4850
EYAKSVKLLS EKQYWLKAIA EGVEFLDMNE NAGAFKVEDS RTFSTELEKE
4860 4870 4880 4890 4900
ETKRLLRETN RAYHTEINDI LITALLVAAR DMNGQNQLRI TLEGHGREQV
4910 4920 4930 4940 4950
ADGIDISRTV GWFTSKYPVF IDLGQETDMS RTIKMVKEHL RNVPNKGIGY
4960 4970 4980 4990 5000
GILKYLTRDS EIAKGAASPI LFNYLGQLDE DINSGEFSSS HLSPGEAAGK
5010 5020 5030 5040 5050
GITREHPLEI NAVVFRGKLA IQTTYNTRAY SEDVVRAFAQ NYKEALKAVI
5060 5070 5080 5090 5100
RHCAEREETE KTPSDYGDKG ISLDQLEEIK LKYKGMEIEK IYPLANMQRG
5110 5120 5130 5140 5150
MLFHALEDKE SQAYFEQMAI NMKGLIDERL FAETFNDIME RHEILRASIE
5160 5170 5180 5190 5200
YEITDEPRNV IIKDRKINLD YHDLRKQSPA EREQVIQAYR KADREKGFRL
5210 5220 5230 5240 5250
NSEPLIRAAL MRTEDDSYTF IWTNHHILLD GWSRGIIMGE LFHMYHMKEA
5260 5270 5280 5290 5300
RQKHRLEEAR PYSDYIGWLQ QQDKEAAKAY WRNYLSGFTE KSPISVLAGS
5310 5320 5330 5340 5350
SGHAKYKRKE AVIEFPEQLT GRITELASRN NVTFHTVLQC IWGMLLARYN
5360 5370 5380 5390 5400
QTDDVVFGTV ISGRDAQVTG IEKMVGLFIN TVPTRIRLDK SQSFKELIKS
5410 5420 5430 5440 5450
VQEQALEGRT YHDMNLSEVQ SLSELKRELL DHILIFENYA VDQSAFETSG
5460 5470 5480 5490 5500
KRGAGFVFEE IHAEEQTNYG FNIVAVPGER LVIKLTYDGN IYHDHIIAGI
5510 5520 5530 5540 5550
KGHLQQVMEQ VVQHEDQSLN DITVLSEAER NRLLYEWNDT KAEYPNQTIH
5560 5570 5580 5590 5600
RLFEEQAEKT PELAAVVSGN DKLTYRELNE KSNQLARYLR DKGVKADTIV
5610 5620 5630 5640 5650
AIMAERSPEM VVGIMGILKA GGAYLPIDPD YPEERIKYML EDSGAAIILA
5660 5670 5680 5690 5700
DHKQDLGTLH QEAVELTGDF SSYPADNLEP AGNADSLAYI IYTSGSTGKP
5710 5720 5730 5740 5750
KGVMIRQRGL VNYITWADRV YVQGEQLDFA LYSSIAFDLT VTSIFTPLIS
5760 5770 5780 5790 5800
GNRVIVYRHS EDGEPLIRKV FRDQKAGIVK LTPSHLSLVK DMDASGSSIK
5810 5820 5830 5840 5850
RLIVGGEDLK TELAKEITER FHHNIEIYNE YGPTETVVGC MIYQYDAGWD
5860 5870 5880 5890 5900
RQVSVPIGKP ASNVQLYILD ERQEVQPVGI AGELYISGDG VAKGYLNKPE
5910 5920 5930 5940 5950
LTSEKFLPNP FLPGERMYRT GDLAKMRPDG HIEYLGRIDH QVKIRGYRIE
5960 5970 5980 5990 6000
LGEIEHQLLR HSDIKEAAVA AKTDQNNDQV LCAYVVSERD ITQKDIKTFL
6010 6020 6030 6040 6050
AKELPEYMVP SYLLKLDELP LTPNGKVDLK ALPEPDRSAG ALLEYEPPRH
6060 6070 6080 6090 6100
ELEEKMAAIW EDILNIEQIG INANIFDIGA NSLNVMSFVS RLYAELGFRV
6110 6120 6130 6140 6150
PFKDIFSKPT IKELSDFLKH AQDLLKDYTD DCMQLTRAEE GGKNLFCFPP
6160 6170 6180 6190 6200
AASMGIAYMG LAKHLKQHSV YSFNFIPSAN RIRKYADIIK NIQGEGPYTL
6210 6220 6230 6240 6250
IGYSSGGILA FDVAKELNRQ GYEVEDLIII DSKYRTKAEK HQFTEEEYRE
6260 6270 6280 6290 6300
EISKTFELEK YRDVEKLLSD YLVDLVMKSY VYIQNTVTTG AIDGHISYIK
6310 6320 6330 6340 6350
SSDNQRGENM MMWEKATSKT FTVVQGAGTH MQMISKSHPD ILERNARLIH

DIINKTVKI
Length:6,359
Mass (Da):722,943
Last modified:August 1, 1998 - v1
Checksum:i82A273C546253074
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007865 Genomic DNA. Translation: AAC06348.1.
PIRiT31679.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007865 Genomic DNA. Translation: AAC06348.1.
PIRiT31679.

3D structure databases

ProteinModelPortaliO68008.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERibacli-bacc. Thioesterase.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00179.

Family and domain databases

Gene3Di1.10.1200.10. 5 hits.
3.40.50.1820. 2 hits.
InterProiIPR010071. AA_adenyl_domain.
IPR029058. AB_hydrolase.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR001242. Condensatn.
IPR010060. NRPS_synth.
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
IPR001031. Thioesterase.
[Graphical view]
PfamiPF00501. AMP-binding. 5 hits.
PF13193. AMP-binding_C. 5 hits.
PF00668. Condensation. 7 hits.
PF00550. PP-binding. 5 hits.
PF00975. Thioesterase. 1 hit.
[Graphical view]
SMARTiSM00823. PKS_PP. 5 hits.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 5 hits.
SSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR01733. AA-adenyl-dom. 5 hits.
TIGR01720. NRPS-para261. 2 hits.
PROSITEiPS50075. ACP_DOMAIN. 5 hits.
PS00455. AMP_BINDING. 5 hits.
PS00012. PHOSPHOPANTETHEINE. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The bacitracin biosynthesis operon of Bacillus licheniformis ATCC 10716: molecular characterization of three multi-modular peptide synthetases."
    Konz D., Klens A., Schoergendorfer K., Marahiel M.A.
    Chem. Biol. 4:927-937(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 10716 / DSM 603 / NBRC 12199 / NCIMB 8874.

Entry informationi

Entry nameiBACC_BACLI
AccessioniPrimary (citable) accession number: O68008
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is a mixture of at least ten cyclic dodecapeptides, that differ by one or two amino acids. The most abundant is bacitracin A, a branched cyclic dodecapeptide. It contains an N-terminal linear pentapeptide moiety (Ile-Cys-Leu-D-Glu-Ile) with an isoleucine-cysteine thiazoline condensation product and a C-terminal heptapeptide ring (Lys-D-Orn-Ile-D-Phe-His-D-Asp-Asn), in which the free alpha-carboxy group of the C-terminal Asn is bound to the epsilon-amino group of Lys.

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.