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Protein

Bacitracin synthase 1

Gene

bacA

Organism
Bacillus licheniformis
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Activates five amino acids, incorporates two D-amino acids, releases and cyclizes the mature bacitracin.

Catalytic activityi

L-glutamate = D-glutamate.

Cofactori

pantetheine 4'-phosphateCuratedNote: Binds 5 phosphopantetheines covalently.Curated

Pathwayi: bacitracin biosynthesis

This protein is involved in the pathway bacitracin biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway bacitracin biosynthesis and in Antibiotic biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Ligase

Keywords - Biological processi

Antibiotic biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00179.

Names & Taxonomyi

Protein namesi
Recommended name:
Bacitracin synthase 1
Short name:
BA1
Including the following 5 domains:
ATP-dependent cysteine adenylase
Short name:
CysA
Alternative name(s):
Cysteine activase
ATP-dependent leucine adenylase
Short name:
LeuA
Alternative name(s):
Leucine activase
ATP-dependent glutamate adenylase
Short name:
GluA
Alternative name(s):
Glutamate activase
ATP-dependent isoleucine adenylase
Short name:
IleA
Alternative name(s):
Isoleucine activase
Glutamate racemase (EC:5.1.1.3)
Gene namesi
Name:bacA
OrganismiBacillus licheniformis
Taxonomic identifieri1402 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 52555255Bacitracin synthase 1PRO_0000193082Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei574 – 5741O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation
Modified residuei1615 – 16151O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation
Modified residuei2651 – 26511O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation
Modified residuei3694 – 36941O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation
Modified residuei5201 – 52011O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Interactioni

Subunit structurei

Large multienzyme complex of BA1, BA2 and BA3.

Structurei

3D structure databases

ProteinModelPortaliO68006.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini544 – 61168Acyl carrier 1PROSITE-ProRule annotationAdd
BLAST
Domaini1585 – 165268Acyl carrier 2PROSITE-ProRule annotationAdd
BLAST
Domaini2621 – 268868Acyl carrier 3PROSITE-ProRule annotationAdd
BLAST
Domaini3664 – 373067Acyl carrier 4PROSITE-ProRule annotationAdd
BLAST
Domaini5171 – 523868Acyl carrier 5PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni39 – 612574Domain 1 (isoleucine-activating)Add
BLAST
Regioni621 – 1037417CyclizationSequence analysisAdd
BLAST
Regioni1109 – 1648540Domain 2 (cysteine-activating)Add
BLAST
Regioni2124 – 2689566Domain 3 (leucine-activating)Add
BLAST
Regioni3164 – 3732569Domain 4 (glutamine-activating)Add
BLAST
Regioni4668 – 5249582Domain 5 (isoleucine-activating)Add
BLAST

Domaini

Consists of five modules and one epimerization domain in the fourth module. Each module incorporates one amino acid into the peptide product and can be further subdivided into domains responsible for substrate adenylation, thiolation, condensation (not for the initiation module), and epimerization (optional), and N methylation (optional).

Sequence similaritiesi

Contains 5 acyl carrier domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.1200.10. 5 hits.
InterProiIPR010071. AA_adenyl_domain.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR001242. Condensatn.
IPR013624. NRPS.
IPR010060. NRPS_synth.
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00501. AMP-binding. 5 hits.
PF13193. AMP-binding_C. 5 hits.
PF00668. Condensation. 5 hits.
PF08415. NRPS. 1 hit.
PF00550. PP-binding. 5 hits.
[Graphical view]
SMARTiSM00823. PKS_PP. 5 hits.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 5 hits.
TIGRFAMsiTIGR01733. AA-adenyl-dom. 5 hits.
TIGR01720. NRPS-para261. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 5 hits.
PS00455. AMP_BINDING. 5 hits.
PS00012. PHOSPHOPANTETHEINE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O68006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAKHSLENG VFHKMTENEK ELILHFNNTK TDYPKNKTLH ELFEEQAMKT
60 70 80 90 100
PDHTALVFGA QRMTYRELNE KANQTARLLR EKGIGRGSIA AIIADRSFEM
110 120 130 140 150
IIGIIGILKA GGAYLPIDPE TPKDRIAFML SDTKAAVLLT QGKAADGIDC
160 170 180 190 200
EADIVQLDRE ASDGFSKEPL SSVNDSGDTA YIIYTSGSTG TPKGVITPHY
210 220 230 240 250
SVIRVVQNTN YIDITEDNVI LQLSNYSFDG SVFDIFGALL NGASLVMIEK
260 270 280 290 300
EALLNINRLG SAINEEKVSV MFITTALFNM IADIHVDCLS NLRKILFGGE
310 320 330 340 350
RASIPHVRKV LNHVGRDKLI HVYGPTESTV YATYYFINEI DDEAETIPIG
360 370 380 390 400
SPLANTSVLI MDEAGKLVPI GVPGELCIAG DGLSKGYLNR EELTAEKFIP
410 420 430 440 450
HPFIPGERLY KTGDLAKWLP DGNIEFIGRI DHQVKIRGFR IELGEIESRL
460 470 480 490 500
EMHEDINETI VTVREDEESR PYICAYITAN REISLDELKG FLGEKLPEYM
510 520 530 540 550
IPAYFVKLDK LPLTKNGKVD RKALPEPDRT AGAENEYEAP RNETEEKLAA
560 570 580 590 600
VWQDVLHVEK AGIHDHFAQM GGHSLHAMEL IAKIKEKMNV EIPLHQLFKL
610 620 630 640 650
ATIKELSAFI EANHQEDKGD TLVTRAADPE NIHEIFPLTG IQLAYLVGRD
660 670 680 690 700
ETFEIGGVAT NLTVEFEADV DLNRFQLTLQ KLIDRHPILR TIVFENGTQK
710 720 730 740 750
ILEATQRYTI ETQDLRGFTE EEINVRILEQ REKMTSKIID PSVWPLFELK
760 770 780 790 800
TFMLPGEKKY FFLNVDPLIC DDSSMKRLIR EFKQLYENPG LQLPSLEYSF
810 820 830 840 850
RDYVLASINF KQTSRYQKDQ QYWLDKLDHF PSAPELPLKS DPAHVAKPSF
860 870 880 890 900
KKFSTFLDGH TWNELKKKAR HHHLTPTSVL CAAYAYILAY WSRQNHFAIN
910 920 930 940 950
LTVFNRIPFH PDVKNMIGDF TSLMLLDIHA EENMSSFWRF ALNVQDTLLE
960 970 980 990 1000
ALEHRHYDGV DVIRNIAKKN GMNKKAVMPI VFTSVLSENP DDSFDSLVDF
1010 1020 1030 1040 1050
DNIHFFSTRT SQVYIDNQVY EINGGLYITW DYVEQIFEHE VIESMFDQYI
1060 1070 1080 1090 1100
AVIQKAVSGE DVSTIQMNEK SRQMISAYND TDQSFDAKPL HELFTGQVKH
1110 1120 1130 1140 1150
GPDRMALKHH DEVMTYQELD EKSNQVARFL IGKGVEKGDY IGVIGKRSLG
1160 1170 1180 1190 1200
TIVNLLAVLK TGAAYIPLDP DYPEERKAYI QSKSNCKFFI SHDVYDKEHI
1210 1220 1230 1240 1250
ERFSKAPVDR KVDLDDMAYV IFTSGSTGKP KGVQITHVPQ RNTILDINEK
1260 1270 1280 1290 1300
FNVTEQDNIM GISSLCFDLS VYDVFGALSS GASLVIIDDQ RDVFSLKETA
1310 1320 1330 1340 1350
EKERITIWNS VPAIMGMTAD VYPDNELNHH LRLILLSGDW IPLQLPATIK
1360 1370 1380 1390 1400
KTFKNAEVIS LGGATEGSIW SIYYPIQKVE EDWKSIPYGK PLANQKIYVL
1410 1420 1430 1440 1450
NQNKQLCPVG VEGELYIGGA GVASGYIHDQ EKTEHSFIQH QELGYIYKTG
1460 1470 1480 1490 1500
DYGVLKEDGY VEFLGRKDSQ VKIRGYRVEM GEIENTLVSH QEITKASVID
1510 1520 1530 1540 1550
YTSPDGIKNL YAFVVAENAI SQLDVKEFLQ KTLPDYMIPA KFVQIEEIPL
1560 1570 1580 1590 1600
TVNGKVDKRT LHDLAEQHTA DEGQRGGRML PENETQAMLL EIWKDIFGLD
1610 1620 1630 1640 1650
SINLDVSYYE IGGDSLKAIS IITEINKRMN VEMPISEIFK NDTIIALDHY
1660 1670 1680 1690 1700
LKNREESDME HPIQKAREKE YYPTSPAQQR MYMLSMLENE RGAYHIPMAL
1710 1720 1730 1740 1750
LVEGRINAMQ LENALKTFLQ RHEILRTGFE IQNNELIQKI YENVDFRLEY
1760 1770 1780 1790 1800
ECLDASITDQ HALMEITSRY CKESIKPFDL SRPPLMRAKL IKIDDIRHIL
1810 1820 1830 1840 1850
VINFHHIISD GVSQGILMNE ILELYSNVPL PEVNVQYKDY VEWNHTFNQS
1860 1870 1880 1890 1900
AAMKKQEAYW LDVYRDIPSK LDFPYDYKRH HIDTFEGSSV FLEMERELSD
1910 1920 1930 1940 1950
HIRKLAKHNG TTLYTVMLSA YYVLLNKYTN QTDIVVGTAA AGRLHPDLQD
1960 1970 1980 1990 2000
VFGVFVNTLA LRNEVDTSYS FKEFLQQTKE RTIAAFDNSE YPFDDLIRKL
2010 2020 2030 2040 2050
NGVRESNRNP LFDTMFVLED ARMFTKQKGD VKLSPIIFEL DNAKFDMIFN
2060 2070 2080 2090 2100
VLDFEQKIVL NIEYSTSLFK DETIQKIAED YFRILEEVSE NLDVALHQID
2110 2120 2130 2140 2150
MISRQEKRTL LESFNHTKTA YPKGKAIHQL FEEQAKRIPD HTAVVFEDQK
2160 2170 2180 2190 2200
LTYRQLNEKA NQVARLLREK GVKPDTLVGI MMERSSDMIA AILGVLKAGG
2210 2220 2230 2240 2250
AYLPIDPEYP PERMRYMAFD SEVKVIISDV PLAEELTAES IELIHMDDER
2260 2270 2280 2290 2300
IAGQDRSDID NVNQSGDLAY VIYTSGSTGK PKGVMIEHQS LINLCSWHQS
2310 2320 2330 2340 2350
CFEVGQNDNS SIYASISFDA FVWELFPYIT AGATVHVLNQ ETRLDVEKLN
2360 2370 2380 2390 2400
RYFHDHHITI SFLPTPVCEQ FTALDNHSLR TLLTGGDKLN VFKEKSYQIV
2410 2420 2430 2440 2450
NNYGPTENTV VATSFPIDKS HQNIPIGKPI DNVKVYILNK DLQLCPLGAS
2460 2470 2480 2490 2500
GELCIAGEGL ARGYVNRPEL TREKFIGNPF VPGERMYRTG DLAKMLPDGN
2510 2520 2530 2540 2550
IQFLGRVDQQ VKIRGYRIEP GEIENRLLKY EKIEEAAVIA REDGDHDPYL
2560 2570 2580 2590 2600
CAYVTVKKEV EPEKIRAFLK KSLPDYMIPQ YFVQLDGLPL TVNGKVDKKS
2610 2620 2630 2640 2650
LPVPERSVTM DRRYEAPRDQ MEEKLVSIWE EALGINKIGI NSHFFEAGGH
2660 2670 2680 2690 2700
SLKAAALVST IHKELNVKLP LRQIFETPTI KGLRDISVRR RKCFYIDRKT
2710 2720 2730 2740 2750
EEKPYYRLSS AQKRLYILSQ TGSHVAYNMP FAMTLEGDFD IRRFENTLKN
2760 2770 2780 2790 2800
MVKRHESFRT SFVMIDGEVM QQIEKEIDFQ VAYSDIGKES AEEKIKSFIR
2810 2820 2830 2840 2850
PFHLEKAPLL RAEVVKLNER EHLLMFDMHH IISDGVSTDI FIQELGALYE
2860 2870 2880 2890 2900
GKSLKPFHIQ YKDYAEWENS HARSEELKRQ EEYWLKTYKG DIPVLDLPID
2910 2920 2930 2940 2950
HKRPLTKSSE GDTVTAAIES ETFRKLQHMA KENGVTMYML LLAGYTALLS
2960 2970 2980 2990 3000
KYTGQEDIIV GTPAAGRNHE DIQHLIGMFV NTLAIRNHPE GKKTFRDYLQ
3010 3020 3030 3040 3050
EVKENTLQAY ENQDYPFEEL VEKVNIKRDM ARNPLFDTML VYHNTDVKPF
3060 3070 3080 3090 3100
EAEGLRSRLV EIKRGISKFD ITVTASEAAD GLRLEVEYST TLFNKERMER
3110 3120 3130 3140 3150
LSEHLISLLE QAADHPDIAI NQIDVLTKGE RHRVLYDFNR TDGVFCKEMT
3160 3170 3180 3190 3200
IPELFEKQAE KTPDHPAVAF GDETISYREL NERANSLAFT LRQKGVGPDV
3210 3220 3230 3240 3250
IAGILTERSI EMIVGIMGIL KAGGAYLPID PAYPQERISY IVKDSDVSVL
3260 3270 3280 3290 3300
CAAGDVDPGE AYTGDIIRID QTGQNDHVEN LKHDIKPQHL AYVIYTSGST
3310 3320 3330 3340 3350
GKPKGVMIEH HSVNNLVHGL NERIYQHLDA HLNVALVAPY IFDASVKQIF
3360 3370 3380 3390 3400
AALLFGHTLC IVPRETAWDA MSLIEYYSKN NINVSDMTPA HLNMLAYVDK
3410 3420 3430 3440 3450
TELEFDVKEL IVGGDALTPD VIGGLFHKFP NLSCNITNVY GPTECCVDAA
3460 3470 3480 3490 3500
SHQIESGKVP QTPSIPIGRP LLNTSIYIVD KELRPLPVGI AGELCIAGEG
3510 3520 3530 3540 3550
VARGYVNRPE LTAEKFVDHP FEPGKKMYKT GDLAMWLPDG QIEFLGRADH
3560 3570 3580 3590 3600
QVKIRGYRIE LGEVEQQLLT HEKIKEAAVI AGKDQNGNSY LCAYIASDKE
3610 3620 3630 3640 3650
LPAADVRQFL EREMPDYMIP SYFVKLDRLP RTPSGKVDRS ALPEADGNVN
3660 3670 3680 3690 3700
VMEGTGYDPP RNEIERKLVQ VWREILGAED IGISHHFFAA GGDSIKALQI
3710 3720 3730 3740 3750
VSRLAKMNLK LEMKALFANP KIKDLSRFIT EETRHRKHNK PVTGETELLP
3760 3770 3780 3790 3800
IQKRYFANNK EELDHFNQSF MLFRKDGYDE NIVRTAFNKI LEQHDALRMI
3810 3820 3830 3840 3850
YEEKDGDIIQ YNRGYRENLF DLDVYDVRGF DSQEEKVFEL ATGIQKKSSI
3860 3870 3880 3890 3900
RKGKLVHLGI FRADEGDHLL IAIHHLVVDG VSWRILFEDF ETLYLQALKG
3910 3920 3930 3940 3950
EPLDIGYKTD SYQEFARQLK KYAQSRRLLK EREYWQKALE ADVPFIPAEK
3960 3970 3980 3990 4000
LERDTFEHSA TLSIRIGPDV TAKLLRNAFK AYNTEINDIL LTALIAAVRD
4010 4020 4030 4040 4050
ITGENKLKVM MEGHGREDIL DGVDITRTIG WFTTVYPVFI DLGEEKEISQ
4060 4070 4080 4090 4100
NIKMVKEALR KIPNKGIGYG VLKYMTEELQ KIQTQAPLSF NYFGEMNNDM
4110 4120 4130 4140 4150
NRKVFSQSPF SPGESIGGKI VRHCAIEMNA ISLNGELTIY TTFNQDQYQT
4160 4170 4180 4190 4200
STIEQLNQSF KENLEKIVDH CVDKEGSDMT PSDYGDVSLG LEELELIKDK
4210 4220 4230 4240 4250
YSAFQIEKIY PLANMQKGML FHNAMDQTSG AYFQQIVIKL KGRVHPDILE
4260 4270 4280 4290 4300
ESFHEIVKRH EILRASFEYE ITAEPRQIIA RDRKTPFTSI DLTGENRTRQ
4310 4320 4330 4340 4350
HRFIETYLKE DQEKGFDLSS EALMRVCLIK MSDESYRLIW SHHHILLDGW
4360 4370 4380 4390 4400
CLGIVLSELF SLYGKIMKGE SRRLKEPKPY GDYIKWLEKQ DQEEAVAYWK
4410 4420 4430 4440 4450
DYLKGYESRS ELPAFNRGAT SEEYCGKEKV ISFSKELTTK ITRIAKQHHV
4460 4470 4480 4490 4500
TINTVLQGIW GMILAKYKNT DEVVFGTVVS GREAPVDGIE EMVGLFIHTI
4510 4520 4530 4540 4550
PTRISFEGAR SFKEVLKKTQ AESIESNRYS YMNLSEIQVL SEMKRELITH
4560 4570 4580 4590 4600
VMAFQNYAFD EELFRSQSGE TGFELEGVHG KERTNYNFNL TGVLEDEQLK
4610 4620 4630 4640 4650
LKLTFNENVY DNTIIETLEK HIITVAEQVA EDETQTLRDI NLVSKEEQHR
4660 4670 4680 4690 4700
ILHTFNDTKT GYPKDKPLHE LFEEQAMKTP DHTALVFGAQ RMTYRELNEK
4710 4720 4730 4740 4750
ANQTARLLRE KGIGRGSIAA IIADRSFEMI IGIIGILKAG GTYLPIDPET
4760 4770 4780 4790 4800
PRDRIDYMLK NSGAALLVTT DSLLKPFDIK TVDLCSDELH LLSEENLPRV
4810 4820 4830 4840 4850
NRSSDTAYIV YTSGSTGTPK GVVIPHYSAA RVVKNTNYID ITGNDVILQL
4860 4870 4880 4890 4900
SNYSFDGSVF DIFGALLNGA SLVLIEKETV LNTHELAEVI KKEQVSVMFI
4910 4920 4930 4940 4950
TTALFNTLAD INIGCLAKLR KILFGGERAS IPHVRKVLDH VGRDKLIHVY
4960 4970 4980 4990 5000
GPTESTVYAT YYFINEIDDE AETIPIGSPL ANTSVLIMDE AGKLLPIGVP
5010 5020 5030 5040 5050
GELCIAGDGL SKGYLNREEL TAEKFIPHPF IPGERLYKTG DLAKWLPDGN
5060 5070 5080 5090 5100
IEFIGRIDHQ VKIRGFRIEL GEIESRLEMH EDINETIVTV REDEESRPYI
5110 5120 5130 5140 5150
CAYITANREI SLDELKGFLG EKLPDYMIPA YFVKMDKLPL TKNGKVDRKA
5160 5170 5180 5190 5200
LPEPDRSAGT EAEYEAPRNY VEQRIISILE DVLGTERMGI SCHFFDKGGN
5210 5220 5230 5240 5250
SLKAMQAVHS INKTFGIDMR ISTFFKHPTA KSLARFVLTA EAESAVSEEY

AEEEV
Length:5,255
Mass (Da):598,269
Last modified:August 1, 1998 - v1
Checksum:i906E8DD68450F85B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007865 Genomic DNA. Translation: AAC06346.1.
PIRiT31677.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007865 Genomic DNA. Translation: AAC06346.1.
PIRiT31677.

3D structure databases

ProteinModelPortaliO68006.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00179.

Family and domain databases

Gene3Di1.10.1200.10. 5 hits.
InterProiIPR010071. AA_adenyl_domain.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR001242. Condensatn.
IPR013624. NRPS.
IPR010060. NRPS_synth.
IPR020806. PKS_PP-bd.
IPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00501. AMP-binding. 5 hits.
PF13193. AMP-binding_C. 5 hits.
PF00668. Condensation. 5 hits.
PF08415. NRPS. 1 hit.
PF00550. PP-binding. 5 hits.
[Graphical view]
SMARTiSM00823. PKS_PP. 5 hits.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 5 hits.
TIGRFAMsiTIGR01733. AA-adenyl-dom. 5 hits.
TIGR01720. NRPS-para261. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 5 hits.
PS00455. AMP_BINDING. 5 hits.
PS00012. PHOSPHOPANTETHEINE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The bacitracin biosynthesis operon of Bacillus licheniformis ATCC 10716: molecular characterization of three multi-modular peptide synthetases."
    Konz D., Klens A., Schoergendorfer K., Marahiel M.A.
    Chem. Biol. 4:927-937(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 10716 / DSM 603 / NBRC 12199 / NCIMB 8874.

Entry informationi

Entry nameiBACA_BACLI
AccessioniPrimary (citable) accession number: O68006
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 1, 1998
Last modified: May 11, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is a mixture of at least ten cyclic dodecapeptides, that differ by one or two amino acids. The most abundant is bacitracin A, a branched cyclic dodecapeptide. It contains an N-terminal linear pentapeptide moiety (Ile-Cys-Leu-D-Glu-Ile) with an isoleucine-cysteine thiazoline condensation product and a C-terminal heptapeptide ring (Lys-D-Orn-Ile-D-Phe-His-D-Asp-Asn), in which the free alpha-carboxy group of the C-terminal Asn is bound to the epsilon-amino group of Lys.

Keywords - Technical termi

Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.