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Protein

Chlorocatechol 1,2-dioxygenase

Gene

clcA

Organism
Rhodococcus opacus (Nocardia opaca)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

4-chlorocatechol + O2 = 3-chloro-muconate.
3,5-dichlorocatechol + O2 = 2,4-dichloro -muconate.

Cofactori

Fe3+Note: Binds 1 Fe3+ ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi134IronBy similarity1
Metal bindingi169IronBy similarity1
Metal bindingi194IronBy similarity1
Metal bindingi196IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.13.11.1. 4353.

Names & Taxonomyi

Protein namesi
Recommended name:
Chlorocatechol 1,2-dioxygenase (EC:1.13.11.-)
Gene namesi
Name:clcA
OrganismiRhodococcus opacus (Nocardia opaca)
Taxonomic identifieri37919 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeRhodococcus

Pathology & Biotechi

Chemistry databases

DrugBankiDB03793. Benzoic Acid.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000850881 – 257Chlorocatechol 1,2-dioxygenaseAdd BLAST257

Structurei

Secondary structure

1257
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 24Combined sources21
Helixi28 – 43Combined sources16
Helixi47 – 64Combined sources18
Beta strandi67 – 69Combined sources3
Beta strandi88 – 90Combined sources3
Beta strandi103 – 111Combined sources9
Beta strandi122 – 126Combined sources5
Turni135 – 137Combined sources3
Beta strandi139 – 141Combined sources3
Beta strandi148 – 151Combined sources4
Beta strandi157 – 164Combined sources8
Helixi176 – 182Combined sources7
Turni183 – 185Combined sources3
Beta strandi195 – 200Combined sources6
Beta strandi207 – 213Combined sources7
Turni217 – 220Combined sources4
Helixi229 – 231Combined sources3
Beta strandi236 – 240Combined sources5
Beta strandi243 – 253Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S9AX-ray2.47A/B1-257[»]
3O32X-ray2.85A/B1-257[»]
3O5UX-ray2.35A/B1-257[»]
3O6JX-ray2.90A/B1-257[»]
3O6RX-ray2.60A/B1-257[»]
ProteinModelPortaliO67987.
SMRiO67987.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO67987.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

CDDicd03462. 1_2-CCD. 1 hit.
Gene3Di2.60.130.10. 1 hit.
InterProiIPR007535. Catechol_dOase_N.
IPR012817. Chlorcchol_dOase.
IPR000627. Intradiol_dOase_C.
IPR015889. Intradiol_dOase_core.
[Graphical view]
PfamiPF00775. Dioxygenase_C. 1 hit.
PF04444. Dioxygenase_N. 1 hit.
[Graphical view]
SUPFAMiSSF49482. SSF49482. 1 hit.
TIGRFAMsiTIGR02465. chlorocat_1_2. 1 hit.
PROSITEiPS00083. INTRADIOL_DIOXYGENAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67987-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANTRVIELF DEFTDLIRDF IVRHEITTPE YETIMQYMIS VGEAGEWPLW
60 70 80 90 100
LDAFFETTVD SVSYGKGNWT SSAIQGPFFK EGAPLLTGKP ATLPMRADEP
110 120 130 140 150
GDRMRFTGSV RDTSGTPITG AVIDVWHSTN DGNYSFFSPA LPDQYLLRGR
160 170 180 190 200
VVPAEDGSIE FHSIRPVPYE IPKAGPTGQL MNSYLGRHSW RPAHIHIRIT
210 220 230 240 250
ADGYRPLITQ LYFEGDPYLD SDSCSAVKSE LVLPVNKIDI DGETWQLVDF

NFILQHN
Length:257
Mass (Da):28,953
Last modified:August 1, 1998 - v1
Checksum:iD834A96E85A15777
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003948 Genomic DNA. Translation: AAC38251.1.
RefSeqiWP_065493674.1. NZ_CP009112.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF003948 Genomic DNA. Translation: AAC38251.1.
RefSeqiWP_065493674.1. NZ_CP009112.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S9AX-ray2.47A/B1-257[»]
3O32X-ray2.85A/B1-257[»]
3O5UX-ray2.35A/B1-257[»]
3O6JX-ray2.90A/B1-257[»]
3O6RX-ray2.60A/B1-257[»]
ProteinModelPortaliO67987.
SMRiO67987.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

DrugBankiDB03793. Benzoic Acid.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi1.13.11.1. 4353.

Miscellaneous databases

EvolutionaryTraceiO67987.

Family and domain databases

CDDicd03462. 1_2-CCD. 1 hit.
Gene3Di2.60.130.10. 1 hit.
InterProiIPR007535. Catechol_dOase_N.
IPR012817. Chlorcchol_dOase.
IPR000627. Intradiol_dOase_C.
IPR015889. Intradiol_dOase_core.
[Graphical view]
PfamiPF00775. Dioxygenase_C. 1 hit.
PF04444. Dioxygenase_N. 1 hit.
[Graphical view]
SUPFAMiSSF49482. SSF49482. 1 hit.
TIGRFAMsiTIGR02465. chlorocat_1_2. 1 hit.
PROSITEiPS00083. INTRADIOL_DIOXYGENAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLCA_RHOOP
AccessioniPrimary (citable) accession number: O67987
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: August 1, 1998
Last modified: November 30, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.