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Protein

60 kDa chaperonin

Gene

groL

Organism
Aquifex aeolicus (strain VF5)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation
Ordered Locus Names:aq_2200
OrganismiAquifex aeolicus (strain VF5)
Taxonomic identifieri224324 [NCBI]
Taxonomic lineageiBacteriaAquificaeAquificalesAquificaceaeAquifex
Proteomesi
  • UP000000798 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000632641 – 54560 kDa chaperoninAdd BLAST545

Proteomic databases

PRIDEiO67943.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Protein-protein interaction databases

STRINGi224324.aq_2200.

Structurei

3D structure databases

ProteinModelPortaliO67943.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
HOGENOMiHOG000076290.
InParanoidiO67943.
KOiK04077.
OMAiKKQMDET.
OrthoDBiPOG091H00E7.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O67943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAKAIIYNE EARAKLKAGV DKLANAVKVT LGPKGREVIL GKNWGTPVVT
60 70 80 90 100
KDGVTVAKEI ELKDKFENIG AQLVKEVASK TADVAGDGTT TATVLAQAIF
110 120 130 140 150
HEGLRVAASG ANVMEVKRGI DKAVKKIVEE LKKLSKDVKE RKEIEQVATI
160 170 180 190 200
SANNDPEIGK IIADAMEEVG KDGVITVEES KSAETTLEVV KGMQFDRGYL
210 220 230 240 250
SPYFVTDPEK MECVLENPYI LIYEKKITNV KELLPILEQV VRSGRPLLVI
260 270 280 290 300
AEDVEGEALA TLVVNHIKGV LKACAVKAPG FGQRRKDYLG DIAVLTGGQA
310 320 330 340 350
ITEDLGIKLE SVTLDMLGQA EKVVVDKEHT TIIGGKGDPE QIKARIEQIK
360 370 380 390 400
RQIQETTSDY DREKLQERLA KLSGGVAIIR VGAATEAELK EKKYRVEDAV
410 420 430 440 450
HATKAAVEEG IVPGGGVALV RASEALEDLK GDNHDQQLGI DIIKKAVRTP
460 470 480 490 500
LKQIAYNAGY DGSVVLEKVI ELGKEKGVSW GFNAATGEYV DMYEAGIIDP
510 520 530 540
TKVVRTAIEN AASVAGTMLT AEALIADLPE EKKKDITPTD MPELD
Length:545
Mass (Da):58,795
Last modified:August 1, 1998 - v1
Checksum:i6CB190ED6E8BC8B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07897.1.
PIRiC70489.
RefSeqiNP_214512.1. NC_000918.1.
WP_010881448.1. NC_000918.1.

Genome annotation databases

EnsemblBacteriaiAAC07897; AAC07897; aq_2200.
GeneIDi1193993.
KEGGiaae:aq_2200.
PATRICi20961226. VBIAquAeo85532_1703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000657 Genomic DNA. Translation: AAC07897.1.
PIRiC70489.
RefSeqiNP_214512.1. NC_000918.1.
WP_010881448.1. NC_000918.1.

3D structure databases

ProteinModelPortaliO67943.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224324.aq_2200.

Proteomic databases

PRIDEiO67943.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC07897; AAC07897; aq_2200.
GeneIDi1193993.
KEGGiaae:aq_2200.
PATRICi20961226. VBIAquAeo85532_1703.

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.
HOGENOMiHOG000076290.
InParanoidiO67943.
KOiK04077.
OMAiKKQMDET.
OrthoDBiPOG091H00E7.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCH60_AQUAE
AccessioniPrimary (citable) accession number: O67943
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: August 1, 1998
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.