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O67939 (UPPP_AQUAE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:aq_2195
OrganismAquifex aeolicus (strain VF5) [Reference proteome] [HAMAP]
Taxonomic identifier224324 [NCBI]
Taxonomic lineageBacteriaAquificaeAquificalesAquificaceaeAquifex

Protein attributes

Sequence length256 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 256256Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151082

Regions

Transmembrane8 – 2821Helical; Potential
Transmembrane41 – 6121Helical; Potential
Transmembrane75 – 9521Helical; Potential
Transmembrane96 – 11621Helical; Potential
Transmembrane175 – 19521Helical; Potential
Transmembrane208 – 22821Helical; Potential
Transmembrane236 – 25621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
O67939 [UniParc].

Last modified August 1, 1998. Version 1.
Checksum: 17926E9DF2020E51

FASTA25628,466
        10         20         30         40         50         60 
MTEWQAVVLG IVEGISEFLP ISSTGHLILT AHILGIKHTD FVKSFEISIQ LGSILAVVVL 

        70         80         90        100        110        120 
YFNRLIRDYE IWKRIIAAFI PTGIIGFLLY KLIKGFLIGN DLVVVVSLIL GGIILIFADT 

       130        140        150        160        170        180 
YCEKFCYLGD VRELPLRKAF MIGVFQSIAV IPGVSRSGST IIGGMLMGLN RKVAAEFSFL 

       190        200        210        220        230        240 
LAIPTMFAAT TYDLIKSGGS FNAQEWNILI IGFITSFITA LIVVKWFLNF LKSHSLKIFG 

       250 
FYRILIGLVY AAFFLF 

« Hide

References

[1]"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus."
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.
Nature 392:353-358(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: VF5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000657 Genomic DNA. Translation: AAC07896.1.
PIRG70488.
RefSeqNP_214508.1. NC_000918.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224324.aq_2195.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC07896; AAC07896; aq_2195.
GeneID1193989.
KEGGaae:aq_2195.
PATRIC20961218. VBIAquAeo85532_1699.

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycAAEO224324:GJBH-1574-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_AQUAE
AccessionPrimary (citable) accession number: O67939
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: August 1, 1998
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families